In this study, we prepared OKPP hydrogel constructed from, OKGM, ε-PL, and γ-PGA modified by dopamine and l-cysteine. OKPP hydrogel has the ability of injectable and self-healing through the thiol-aldehyde addition and schiff-base reactions, which can solve the problem of long time use and gel breaking. OKPP hydrogel has antioxidant properties and can scavenge free radicals. This hydrogel has good antibacterial effect on Pseudomonas aeruginosa and Staphylococcus aureus, and also has strong adhesion. In the burn wound infection model, OKPP hydrogel can promote wound healing and reduce the production of inflammatory factors. It is proved that this hydrogel has good clinical potential as a wound dressing for burn wound infection.
- Ao Sun
- Danrong Hu
- Zhiyong Qian
