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A novel resistance gene against maize rough dwarf disease was identified, which confers broad resistance to the virus pathogen infecting multiple cereal crops by regulating jasmonic acid (JA) biosynthesis and JA-mediated defence response.

VERNALIZATION INSENSITIVE 3-LIKE 1 regulates intercellular communication during the growth transition after bulb dormancy by epigenetic regulation of callose synthase via the NF-YA7 transcription factor.

The glucose transporter GLUT1 is upregulated in multiple cancers and may contribute to tumour progression, but the underlying mechanisms are poorly understood. Here, the authors show that DHHC9-mediated GLUT1 palmitoylation at Cys207 is crucial for plasma membrane localisation of GLUT1 and for tumourigenesis in glioblastoma cells.

The Chinese tree shrew, Tupaia belangeri chinensis, has been proposed as a potential animal model in biomedical research and drug safety testing. This study presents the full genome of the Chinese tree shrew, identifying common features between the tree shrew and primates.

Strain engineering is promising for improving catalytic capability of biocatalysts, but it is challenging to modify the atomic-scale strain for specific enzyme-like reactions. Here, the authors report the biocatalysts with atomically-resolved Pt clusters laminated on PdAu nanocrystals and show that the tensile strains contribute to the enzyme-like activities greater than that of natural enzymes.

An analysis of 140 floras from China reveals that high species diversity exists in granite and mixed landforms, while low species diversity is found in karst, Danxia, and desert landforms. Based on these findings, the authors provide new clues for understanding the assembly and differentiation of mountain floras, highlighting the role of bedrock and landform processes.

The understanding of catalytic reactions at the atomic interface is vital; however, the characterization and mechanism studies of atomically dispersed catalysts remain challenging. Here, the authors demonstrate Cu–Sn surface alloys with isolated Sn atoms on a Cu host to achieve efficient CO₂ to CO conversion.

Chemoresistance is one of the main challenges for cancer therapy success. Here, the authors show that dual-specificity phosphatase 16 (DUSP16) expression is associated with chemoresistance in several types of cancer through impairing mitochondria-associated apoptosis.

Primary biliary cholangitis is a chronic autoimmune disease critically linked to immunological dysregulation but the local immune-pathogenesis is poorly understood. Here the authors present single cell transcriptomic characterisation of primary biliary cholangitis and implicates Th1 like cells in a murine model.

Gelabert et al. examine genomic and archaeological data from Europe’s earliest farming communities in Central Europe (5500–5000 bce). They find differentiated genetic networks but no evidence of unequal access to resources linked to sex or kin.

The deubiquitinase PICI1 is identified as part of an immunity hub that coordinates pattern- and effector-triggered immunity and is involved in conferring broad-spectrum resistance to blast across different subspecies of rice.

Early detection and accurate diagnosis of focal liver lesions are crucial for effective treatment and prognosis. Here, the authors present a fully automated diagnostic system that leverages multi-phase CT scans and clinical features, for diagnosing liver lesions.

Coinage-metal-based cyclic trinuclear complexes have potential in diverse applications, but their use in biochemical applications has been limited due to particle size and hydrophobicity. Here, the authors report the development of such complexes with multi-photon luminescent properties for use in cell imaging.

Nonalcoholic steatohepatitis (NASH) is a heterogeneous disease with complicated pathogenesis. Here the authors identify that the E3 ligase TRIM26 confers protection against NASH development via suppression of CCAAT/enhancer binding protein delta (C/EBPδ).

γ-glycidoxypropyltrimethoxysilane was used as a bridge between hydrophobic particles and polyurethane to prepare dual-repellent coating in aqueous environment. This coating demonstrates superior mechanical strength, antifouling properties, and self-cleaning capabilities. In comparison to the uncoated substrate, the amphiphobic coating exhibited a 9-minute delay in freezing time and a reduced adhesion strength of 17 kPa. These results highlight the promising potential of the PKF-SiO₂ coating for enhancing antifouling and self-cleaning functionalities in various applications, including textiles and construction

A mixed-dimensional hot-emitter transistor based on mixed-dimensional graphene/germanium Schottky junctions uses stimulated emission of heated carriers, achieving an ultralow subthreshold swing and a high negative differential resistance.

Ultrahigh electromechanical response is accomplished by inducing extreme structural instability from competing antiferroelectric and ferroelectric orders.

A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.

TEMPOmap combines pulse-chase metabolic labeling with multiplexed three-dimensional in situ sequencing to simultaneously profile the age and subcellular ___location of individual RNA molecules from thousands of genes to reveal RNA kinetic landscapes.

The genetic bases of yak adaptations to extreme conditions remains elusive. This study compares yak and cattle at a genomic and transcriptomic level, revealing a new type of endothelial cell and candidate genes related with elastic fiber formation in yak lungs that might contribute to high altitude adaptation.

Chiral Brønsted acid catalysis is mostly limited to the activation of imine and carbonyl moieties. Now, by direct activation of alkynes, chiral Brønsted acids have been used to enable the catalytic asymmetric dearomatization of naphthol-, phenol- and pyrrole-ynamides for the construction of various spirocyclic enones and 2H-pyrroles bearing a chiral quaternary carbon stereocentre.

Polyoxometalates (POMs) are molecular clusters with diverse structures. Here authors present the synthesis of POMs by Ce-mediated molecular tailoring from gigantic {Mo₁₃₂} into half-closed {Ce₁₁Mo₉₆}, with proton conductivity nearly two orders of magnitude higher than {Mo₁₃₂}.

Alkyne hydroboration into vinylboronate esters is an important reaction, yet reaching high selectivity of targeted functional groups is challenging. Here, the authors develop dual-site copper clusters to achieve highly selective hydroboration.”

Volcanism identified by Pb–Pb dating of basalt fragments returned by the Chang’e-6 mission from the farside of the Moon gives a young eruption age of 2,807 ± 3 Ma, consistent with the crater-counting age.

The bacterial adhesin, RadD, enhances the ability of Fusobacterium nucleatum to interact with colorectal cancer cells and promote tumour development in mice.

Callus browning heavily affects indica rice transformation regeneration. Here, the authors show transposon insertion in the promoter of BOC1 gene, encoding a SIMILAR TO RADICAL-INDUCED CELL DEATH ONE protein, can upregulate its expression and decrease callus browning in cultivated rice by releasing oxidative stress.

By using 1 W optical frequency combs and nanowatt-level linear optical sampling modules, a time–frequency dissemination over a free-space link of 113 km is achieved with a stability of less than 4 × 10⁻¹⁹ at 10,000 s.

Heteroatom–heteroatom cross-couplings have so far remained elusive. Now, a copper-catalysed enantioselective S–O cross-coupling of diverse diols or triols with sulfonyl chlorides has been realized via a single-electron reductive elimination manifold. The reaction provides access to value-added chiral C₃ building blocks and inositol phosphates through enantioselective desymmetrization of biomass-derived alcohols.

The neural circuit mechanisms underlying chronic pain and comorbid anhedonia remain poorly understood. Here, the authors show the critical role of the DRN–VTA–NAcMed pathway in establishing and modulating chronic neuropathic pain and comorbid anhedonia.

Producing H₂ from water using electricity and earth-abundant elements is necessary for worldwide renewable fuel production, yet most electrocatalysts have sluggish activities or poor stabilities. Here, authors show vanadium oxide modified copper-doped nickel to enable active and durable H₂ evolution.

Integrative analyses of single-cell datasets are facing new challenges as data size and complexity grow. Here the authors present SCALEX, which projects cells from different datasets into a common latent space, allowing accurate online integration as well as cross-referencing with atlas-scale data.

Excitonic insulators remain a topic of great interest in condensed matter physics. Here, the authors provide spectroscopic evidence of increased electronic coherence in the charge-density-wave state of semiconducting 1T-TiSe₂.

The neural mechanisms of memory consolidation during sleep are poorly understood. Here the authors show that isolated theta waves from nucleus reuniens initiate neural ensemble reactivation during sleep required for spatial memory consolidation.

A small driving pressure is desirable for practical application of barocaloric materials. Here, the authors demonstrate a sensitive barocaloric effect in NH₄I due to strong reorientation-vibration coupling.

Vacancies are traditionally considered to play a role of phonon-defect scattering. Here, the authors show that vacancies can induce phonon softening, enhance phonon anharmonicity, and cause a dramatic reduction in the lattice thermal conductivity.

Cryo-EM structures reveal the molecular mechanism of ligands and G protein selectivity for prostaglandin F_2α receptor, providing guidance for development of better postpartum hemorrhage drugs.

Using 1,578 resequenced genomes representing the diversity of cultivated and wild rice, this study reveals that the domestication alleles of the 993 selected genes stemmed from both O. rufipogon and O. nivara, demonstrating multiple domestications of rice.

A general copper-catalysed enantioconvergent C(sp³)–C(sp) cross-coupling of diverse racemic tertiary alkyl halides with terminal alkynes has been developed, forging all-carbon quaternary stereocentres. Key to the success is the rational design of chiral anionic N,N,N-ligands tailor-made for the computationally predicted outer-sphere radical group transfer pathway.

RNA editing and circRNAs are involved in tumorigenesis. Here the authors report that ADARs regulate the circular transcriptome in a bidirectional manner through and beyond their editing function in multiple cancer cells.