Nature Search

Oral antioxidant edaravone protects against cognitive deficits induced by chronic hypobaric hypoxia at high altitudes

Yuan-Yuan Ma
Xin Li
Yan-Jiang Wang
ResearchOpen Access03 Oct 2024
Translational Psychiatry

Volume: 14, P: 1-13
ProBDNF/p75NTR/sortilin pathway is activated in peripheral blood of patients with alcohol dependence

Li Zhou
Jing Xiong
Xin-Fu Zhou
ResearchOpen Access09 Mar 2018
Translational Psychiatry

Volume: 7, P: 1-10
Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity

Lactic acid from glycolytic metabolism of cancer cells has been associated with immune suppressive functions. Here authors show that lactate, when depart from the acidic protons, inhibits histone deacetylases in CD8 + T cells, which turns them into potent anti-tumour immune cells.

Qiang Feng
Zhida Liu
Jinming Gao
ResearchOpen Access06 Sept 2022
Nature Communications

Volume: 13, P: 1-13
Author Correction: A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8⁺ T-cell response and effective tumor control

Zhichen Sun
Zhenhua Ren
Hua Peng
Amendments and CorrectionsOpen Access01 Apr 2020
Nature Communications

Volume: 11, P: 1
A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8⁺ T-cell response and effective tumor control

Interleukin-2 (IL-2) based cancer therapy is limited by severe toxicity and strong Treg amplification at the therapeutic dosage. Here, the authors develop a recombinant IL-2 immunocytokine which is comprised of a tumor-targeting antibody fused to a super mutant IL-2 and show in mouse models that this next-generation IL2 has reduced toxicity and enhanced antitumor activity.

Zhichen Sun
Zhenhua Ren
Hua Peng
ResearchOpen Access28 Aug 2019
Nature Communications

Volume: 10, P: 1-12
Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance

Despite the presence of tumor-infiltrating lymphocytes, many patients do not respond to PD-L1/PD-1 blockade therapy. Here they show that PD-L1 antibody armed with interferon-α (IFNα) improves tumor targeting and antigen presentation while countering innate or T-cell-drive PD-L1 upregulation, and overcomes resistance to checkpoint blockade therapy.

Yong Liang
Haidong Tang
Yang-Xin Fu
ResearchOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1-11
Prognostic significance of pre- and post-operative tumour markers for patients with gastric cancer

Jun-Peng Lin
Jian-Xian Lin
Chang-Ming Huang
ResearchOpen Access26 May 2020
British Journal of Cancer

Volume: 123, P: 418-425
Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine

Zhida Liu
Chang Zhou
Wei Liang
ResearchOpen Access04 Apr 2017
Cell Discovery

Volume: 3, P: 1-14
Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation

Yuan Zhang
Tae-Jin Kim
Yang-Xin Fu
Research05 Jun 2017
Cellular & Molecular Immunology

Volume: 15, P: 697-709

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