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A general two-step intercalation and cation-exchange strategy is used to produce a library of highly ordered magnetic intercalation superlattices with tunable chemical modulations and magnetic ordering.

A graphene-nanopocket-protected pure Pt nanocatalyst has been reported for heavy-duty-vehicle fuel cells that deliver high power density, high efficiency and exceptional durability with >200,000-h projected lifetime.

A simple but flexible technique based on a capillary-force-driven rolling-up process produces high-order van der Waals superlattices that are hard to produce with existing fabrication techniques.

Conventional theories for interfacial thermal transport are derived from bulk phonon properties. Here, the authors report experimental observation of interfacial phonon modes localized at interfaces, changing how interfacial thermal transport should be understood.

An end-to-end pipeline generates the optimal copy number combination of genes in a biosynthetic pathway for chromosomal integration to engineer high-performing strains with genetic stability.

Prime editing in bacteria is currently inefficient. Here the authors report BacPE, a versatile prime editing platform in Escherichia coli that works by inhibiting 3′→5′ DNA exonucleases, highlighting the intrinsic genetic factors that are adverse to efficient prime editing.

A subcutaneously injected hydrogel conjugated with antibodies for interleukin-6 substantially reduces the levels of the cytokine during chimaeric antigen receptor T-cell therapy while maintaining its antitumour efficacy.

Identification of CRISPR-Cas systems by sequence alignment is limited by homolog sequence diversity. Here, the authors develop CHOOSER, and AI framework, for alignment free discovery of CRISPR-Cas systems, including EphcCasλ, which was validated for self-processing and DNA cleavage.

Cellular progression through mitosis is largely controlled by the APC-Cdh1 complex. Zhang and colleagues report that, when the Cdh1 gene is disrupted, cells undergo premature p16-dependent senescence, and that Cdh1-deficient mice show impairment of hippocampus-dependent learning and memory.

Li, Cheng, Yu and colleagues have discovered a Cas13j family, including the compact and highly efficient LepCas13j (529 aa) and ChiCas13j (424 aa), with promising applications in RNA editing in vivo.

This paper describes the use of paired Cas9 nickases to edit the mammalian genome with no detectable off-target effects.

Inverse Protein Folding is a critical component of protein design. Here, authors introduce ProRefiner, a deep-learning model for IPF that exhibits both high performance and memory efficiency, thereby contributing to advancements in protein design.

Researchers demonstrate a size-dependent lanthanide energy transfer effect in upconversion nanoparticles with depleted surface quenching, resulting in upconversion quantum yields of 13.0 ± 1.3%.

Strategies to improve the specificity of nuclease-based prime editor (PEn) are needed. Here the authors report a 53BP1-inhibitory ubiquitin variant-assisted PEn platform (uPEn) to inhibit NHEJ and enable precise prime editing for generation of insertions, deletions and replacements.

A new fusion protein enables precise editing of single bases in A/T-rich regions of the human genome.

The striped polarization domains in a BiFeO₃/TbScO₃ heterostructure induce alternating p- and n-type doping at the interface, giving rise to strongly anisotropic in-plane conductance.

The prime editors (PEs) have shown great promise for precise genome modification. Here the authors place a stabilizing viral xrRNA motif to the 3′ of pegRNAs to enhance editing efficiencies.

Two-dimensional electron gases that form in some complex oxide heterostructures may have useful functional behavior due to the interaction of the parent materials. Here the authors show that PZT/STO interfaces can host a spin-polarized electron gas, even though the bulk materials are nonmagnetic.

The evolution of epigenetic regulation of brain development in primates is not well understood. Here, the authors perform a comparative study of epigenetic dynamics of early prefrontal cortex development between human and rhesus macaque, finding divergent regulatory elements that may be related to cognitive capacity.

A general strategy for the synthesis of two-dimensional van der Waals heterostructure arrays is used to produce high-performance electronic devices, showing the potential of this scalable approach for practical technologies.

DNA base editors can display off-target effects on DNA and RNA. Here the authors embed the base editing enzymes in the middle of nCas9 to reduce these without impacting on-target editing.

“Reinvigoration of antitumor immunity has recently become the central theme for the development of cancer therapies. Here the authors present an adaptable gene circuit to harness the CRISPRa for tumorlocalized immune activation.”

Ultrafine catalysts are desirable for the reduction of fuel cell costs but are intrinsically unstable. Here the authors report graphene-nanopocket-encaged PtCo catalysts with exceptional durability under the demanding ultralow-Pt-loading condition while delivering a satisfactory fuel cell performance.

While heterogeneous catalysts can act as tangible, efficient materials for energy conversion, understanding the active catalytic sites is challenging. Here, authors engineer specific catalytic sites into molybdenum sulfide to improve and elucidate hydrogen evolution electrocatalysis.

Genes normally expressed in the testis but aberrantly expressed in cancer are termed cancer testis antigens. In this study, the authors catalogue the expression of these genes in 19 different cancer types and correlate expression with some somatically mutated oncogenes.

A real-space imaging technique that combines scanning transmission electron microscopy with an angle-resolved pixellated fast-electron detector is used to image the charge distribution in SrTiO₃, BiFeO₃ and the junction between them.

CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.

Neuronal stimulation induces protein translation of m⁶A-methylated neuronal mRNAs facilitated by YTHDF1, and this process contributes to learning and memory.

Wang et al. developed a transformer base editor system in which the enzyme activity of the base editor is turned on only at the on-target site, therefore minimizing genome-wide and transcriptome-wide off-target mutations.

Supported metal single-atom catalysts face challenges on both durability and practicality. Here, the authors demonstrate that a sustained 90% diesel oxidation conversion at ~160 ^oC is achieved by single-atom Pt on TiO₂ nanowire-array integrated catalytic converter.

A recently discovered fossil belonging to the Scansoriopterygidae, a group of bizarre dinosaurs closely related to birds, represents a new scansoriopterygid species and preserves evidence of a membranous aerodynamic surface very different from a classic avian wing.

Genomic deletion of the tumour suppressor TP53 frequently includes other neighbouring genes, such as the POLR2A housekeeping gene that encodes a crucial RNA polymerase II subunit; suppression of POLR2A with α-amanitin or by RNA interference selectively inhibits the tumorigenic potential of cancer cells, and in mouse models of cancer, tumours can be selectively targeted with α-amanitin coupled to antibodies, suggesting new therapeutic approaches for human cancers.

The discovery of a new species of Tyrannosaurus relative from the Early Cretaceous of China, some 125 million years old—the largest feathered creature known, living or extinct—has implications for early feather evolution.

The early evolution of the major groups of derived non-avialan theropods is not well understood, resulting in the 'temporal paradox' argument against the theropod hypothesis of avian origins. Here, a small theropod specimen collected from the earliest Late Jurassic of China is recovered that is referable to the Troodontidae, which are among the theropods most closely related to birds, thus refuting the 'temporal paradox'. Furthermore, the extensive feathering of the specimen sheds new light on the early evolution of feathers.

A number of paravian dinosaurs have been described from the Jurassic Yanliao biota, but these have tended to be morphologically similar to Archaeopteryx. Here, Hu. describe the new paravian dinosaur, Caihong juji gen. et sp. nov., which possesses a suite of unusual skeletal and feather characteristics.

Study of two specimens of the feathered dinosaur Similicaudipteryx shows that the morphology of dinosaur feathers changed dramatically as the animals matured. Moreover, the morphology of feathers in dinosaurs was much more varied than one would expect from looking at feathers in modern birds.