Jung-A A. Woo et al. show that activated cofilin competes with Tau for microtubule biding in primary neuronal cultures and a C.elegans model. This direct binding decreases microtubule stability and promotes tauopathy, suggesting an important role for cofilin in neurotoxic signaling.
- Jung-A. A. Woo
- Tian Liu
- David E. Kang
