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TUG protein localizes to the endoplasmic reticulum-Golgi intermediate compartment, forms biomolecular condensates, and organizes and stabilizes these membranes to support their function in diverse secretory and degradative trafficking pathways.

A nanofluidic intracellular delivery (NanoFLUID) patch provides a versatile, biocompatible and efficient method for the targeted delivery of payloads to internal organs for therapeutic purposes and for biomolecular investigations.

Cerebral asymmetry, crucial for cognitive functions, often changes in neuropsychiatric disorders. This study maps structural brain asymmetry in 11,000 children aged 10–14 years, identifying age-related patterns linked to genetics, environment, cognition, and psychiatric risks.

By using a scanning probe to control the polarization of ferroelectric polymers deposited on the surface of two-dimensional transition metal dichalcogenides, optoelectronic and unconventional memory devices can be created based on lateral p–n junctions.

This study uses genetic crossing to identify the genes underlying the differences in virulence between two Cryptosporidium isolates. Candidate genes are validated using genetic editing, revealing that the small granule protein SKSR1 is a key virulence factor in Cryptosporidium.

Global mercury emissions increased 330% from 1960–2021, with declines in the Global North and China offset by rapid growth in the Global South, which now produces two-thirds of emissions. Without urgent action, emissions could rise 10%–50% by 2030.

Glycosphingolipids (GSLs) are abnormally expressed in cancer cells. Here, in addition to showing that inhibition of the synthesis of GSLs with eliglustat promotes anti-tumor immune responses in preclinical models, the authors report the results of a phase I trial of eliglustat and anti-PD-1 antibodies for the treatment of advanced cancers.

The histone deacetylase HDAC6 is a sensor of valine levels, and the abundance of valine in cells regulates DNA damage and cell homeostasis functions.

One challenge in lignin valorization is that microorganisms possessing downstream metabolic advantages are unable to convert lignin. Here, the authors engineer the non-lignin-degrading bacterium Ralstonia eutropha to efficiently convert lignin into polyhydroxybutyrate using a self-enhanced autoregulation system.

The study identifies transcription factor OsGATA8 as a negative regulator of nitrogen uptake and tiller formation in rice and OsGATA8-H as an elite haplotype with reduced expression and enhanced nitrogen use efficiency.

Authors find room-temperature ferroelectricity in single element Te nanowires, highlighting that reducing dimensions to 1D in low-dimensional piezoelectric materials with chain structures is an effective strategy to induce ferroelectricity absent in their 2D form.

The authors develop a metabolic engineering strategy for improving polyketide production of industrial interest and discovering new natural products in bacteria.

Ultrathin films of gallium oxide with a dielectric constant of around 30 can be formed on the surface of molybdenum disulfide using a liquid metal-based approach and used as the gate insulator in transistors.

The authors realize low-pressure-driven polarization switching in PbTiO₃ membranes by leveraging their structural tunability and substrate elasticity, enabling ferroelectric field-effect transistors on silicon, operatable mechanically and electrically.

Post-prediction genome-wide association study (POP-GWAS) is a statistical framework that uses summary statistics from labeled samples with both observed and imputed phenotypes to debias single-nucleotide polymorphism effect size estimates for unlabeled samples with imputed phenotypes only, leading to valid and powerful inference.

The mechanism of the charge density wave in kagome metals is not fully understood. Here, the authors report the observation of unusual large-frequency collective lattice excitations, or amplitude modes, in CsV₃Sb₅ in the absence of phonon mode softening, evidencing the strong electron-phonon coupling regime.

How excitatory neurons (EN) acquire senescence is unclear. Here, the authors show that GDF11 in ENs slows EN senescence, brain ageing, cognitive decline and maintains lifespan, revealing a mechanism underlying EN senescence and brain ageing.

A biodegradable electronic bandage that applies pulsed and d.c. electrostimulation can accelerate the healing of intestinal wounds in mice via transfection of cells and stimulation-induced secretion of healing factor from those cells.

The complex redox processes in lithium–sulfur batteries are not yet fully understood at the fundamental level. Here, the authors report operando confocal Raman microscopy measurements to provide mechanistic insights into polysulfide evolution and sulfur deposition during battery cycling.

Wu et al. demonstrate that HER2 recruits AKT1 to disrupt the STING signalosome, thereby suppressing damage-induced cellular senescence and STING-mediated antiviral and antitumour responses in vivo.

An oral inulin allergen gel restores the microbiota of allergic mice and suppresses undesired immune responses to achieve allergen-specific oral tolerance, effectively overcoming food allergy.

Using a monolayer molecular crystal as a seeding layer, hafnium oxide dielectrics with an equivalent oxide thickness of only 1 nm can be deposited on graphene, molybdenum disulfide and tungsten diselenide.

Structures of complexes containing GajA and GajB proteins of the prokaryotic Gabija anti-phage defence system reveal the mechanism of its activation after DNA cleavage upon ATP depletion.

Using data-driven disease-progression modelling, Jiang, Wang, Zhou et al. characterized and replicated two distinct ‘trajectories’ of brain atrophy in patients with schizophrenia.

By integrating split ferroelectric capacitors with complementary characteristics in the same memory cell, this architecture tackles the problem of conflicting memory requirements for training and inference, which has long plagued edge intelligence applications.

Unzipping carbon nanotubes produces high-quality graphene nanoribbons with smooth edges for revealing the intrinsic quantum transport phenomena in these materials.

Individual antibodies identified in the blood of people triple-vaccinated against SARS-CoV-2 predominantly bind spike protein and are highly effective at neutralizing SARS-CoV-2 variants, including Omicron (B.1.1.529).

The optical response of inorganic two-dimensional semiconductors is dominated by Wannier-Mott excitons, but molecular systems can host localised Frenkel excitons. Here, the authors report strong optical response in a class of monolayer molecular J-aggregates due to the coherent Coulomb interaction between localised Frenkel excitons.

Inorganic two-dimensional atomic crystals exhibit a variety of unusual but practically useful properties. Here, the authors produce an organic counterpart, atomically smooth monolayers of a molecular crystal, and use this organic analogue of graphene in high-performance organic field-effect transistors.

A solution-based lithography-assisted epitaxial-growth-and-transfer method is used to fabricate single-crystal hybrid perovskites on any surface, with precise control of the thickness, area and chemical composition gradient.

Cities can be treated as dynamic complex systems being controlled by the interactions among people, whilst the detail remains largely unknown. Li et al. use spatial attraction together with matching growth to unify population, roads, and socioeconomic interactions crossing ten representative cities.

NF-κB activation mediated by TNFα has a critical role in inflammation; however, the underlying mechanisms await further investigation. Here the authors show that selective autophagy regulates NF-κB activation via an ANGPTL8/p62-IKKγ signaling axis.

Identification of pathways that drive proper cardiac function is key to prevention and treatment of heart disease. Here the authors describe a novel pathway that regulates cardiomyocyte survival, which involves a sorting protein, SNX13, and its binding partner, ARC, a multifunctional inhibitor of apoptosis.

Zhang et al. show that YAP and TAZ suppress nucleic acid sensing and antiviral responses by inhibiting the TBK1 kinase. Conversely, Hippo pathway activity inactivates YAP/TAZ to relieve TBK1 suppression and enhance antiviral defence in zebrafish.

Screening for small-molecule epigenetic modulators identifies HDAC3 inhibitors that promote peripheral myelin repair after nerve injury in rodents.

An emerging research area in AI is developing multi-agent capabilities with collections of interacting AI systems. Andrea Soltoggio and colleagues develop a vision for combining such approaches with current edge computing technology and lifelong learning advances. The envisioned network of AI agents could quickly learn new tasks in open-ended applications, with individual AI agents independently learning and contributing to and benefiting from collective knowledge.