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The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

Native crystallographic defects are often introduced during synthesis of battery materials, but has been overlooked. Here, using in situ synchrotron X-ray probes and electron microscopy, the authors have revealed their adverse effect during battery operation.

This article presents a polymeric membrane-enclosed insulin crystal equipped with physiological signal-sensing microdomains, dubbed ‘smart drug crystals’, that enables long-term, glucose- and β-hydroxybutyrate-dually responsive drug release for type 1 diabetes therapy.

Nanoparticles with precisely controlled socketed geometries, created via an ex-solution method, present promising ways to improve the stability of heterogeneous catalysts. Here, the authors demonstrate that adjusting the level of La deficiencies in the oxide support allows tuning of the geometry of Pd-based particles, which in turn influences their catalytic performance in high-temperature oxidation reactions.

Ancient DNA, stable isotopes and other archaeological methods establish that humans were living at extremely high elevation on the Tibetan Plateau 4,400 years ago, maintaining sedentary lifestyles that combined fishing, hunting and crop exchange.

Kagome superconductors host a panoply of condensed matter phenomena, some of which are mediated by band topology. Here, authors use ARPES and DFT to identify type-II and type-III Dirac nodal lines, flat bands and topological surface states in the kagome metal CsTi₃Bi₅.

Guo and colleagues characterize an intact Carnegie stage 7 human embryo at single-cell resolution in a spatially resolved manner.

Orally administrable and glucose-responsive worm-like micelles have been developed to protect insulin in the gastrointestinal tract, enhance its intestinal absorption, accumulate in the liver and enable efficient and safe blood-glucose management.

Single-crystalline perovskite membranes with an ultrahigh dielectric constant show potential as a gate dielectric for two-dimensional field-effect transistors.

This study identifies parallel gut–brain pathways that fine-tune feeding. Distinct brainstem neurons and visceral afferents either sense esophageal stretch to regulate eating speed or detect gut nutrients to shape long-term food choices and satiety.

The authors present a metasurface-assisted isotropic DIC microscopy technique. It is based on an original pattern of radial shear interferometry, that converts rectilinear shear into rotationally symmetric radial shear, enabling single-shot isotropic imaging capabilities.

Lipopolysaccharide-induced breakdown of the blood–brain barrier requires activation of GSDMD-mediated plasma membrane permeabilization and pyroptosis in brain endothelial cells.

Porphyrins are produced at scale through metabolic engineering and optimization of CPIII purification.

Oxygen redox instability at high voltages hinders the application of high-energy battery cathodes. Here the authors report that elimination of ___domain boundaries in single-crystal cathodes improves the redox stability and consequently the electrochemical performance in extended high-voltage cycling.

Layered Ni-rich oxide cathodes are susceptible to challenges with surface reconstruction and strain propagation, limiting their cyclability. The authors propose a solution involving oriented attachment-driven reactions, utilizing Wadsley–Roth nanocrystals and layered oxide to induce an epitaxial entropy-assisted coating, effectively addressing these issues.

The host blood-type-associated ABO genotype affects the abundance of specific bacteria in the pig intestine.

Biodiversity-ecosystem functioning relationships may vary with climate. Here, the authors study relationships of plant and soil microbial diversity with soil nutrient multifunctionality in 130 dryland sites in China, finding a shift towards greater importance of soil microbial diversity in arid conditions.

Whole-genome sequencing analysis of the Central Plains Han Chinese population provides important genetic evidence of the population history and dietary adaptations of the East Asian populations.

An analysis of human chromosome 15 — which is altered in Prader-Willi and Angelman syndromes — reveals that it resembles a hall of mirrors, as it contains a number of sequence duplications throughout its length. The evolutionary events that may have led to the high number of duplications was also reconstructed.

The level of immune response in cancer vaccines can limit application. Here, an immune mobilization strategy, using bacteria-derived nanovesicles, enhances therapeutic outcomes of tumour vaccination by stimulating interleukin-1β secretion to elicit trained immunity with lineage shifts and epigenetic changes in myeloid progenitor pools.

Current methods for analysing protein structures and interactions generally require the separation of specific organelles or changes to the intracellular environment. Here, authors developed nanocarrier-based cross-linking mass spectrometry techniques to assess mitochondrial proteins within living cells.

Here, the authors present a pig integrated gene catalog and metagenome-assembled genomes, which they construct from swine gut microbiomes spanning various ages, sexes, breeds, geographical locations, domestication, and gut locations by metagenomic sequencing, providing expanded resources for pig microbiome studies.

Cryo-electron microscopy structures of mGlu2 and mGlu4 bound to heterotrimeric G_i protein shed light on the molecular basis of asymmetric signal transduction by metabotropic glutamate receptors.

Miscanthus is widely used as a feedstock for cellulosic biofuel production. Genome sequencing shows that M. floridulus is most distantly related to other Miscanthus species and is more genetically diverse.

DNA from neutrophil extracellular traps interacts with the transmembrane receptor CCDC25 on cancer cells, activating the ILK-β-parvin pathway to enhance cell motility and promote distant metastases.

RITF1, a newly identified plant transcription factor, links signalling through the peptide hormone RGF1 to the balance of reactive oxygen species and thereby enhances the stability of another transcription factor, PLETHORA2, a master regulator of root stem cells.

Intensive research efforts are underway to enable applications of layered lithium transition metal oxides in batteries. Here the authors report an oxidative chemical vapour deposition technique to conformally coat both the primary and the secondary particles of these oxides to unleash potential applications.

The design and synthesis of robust sintering-resistant nanocatalysts for high-temperature oxidation reactions remains challenging, even though the strategy of metal-support interactions has been extensively used. Here, the authors demonstrate an alternative strategy for designing robust nanocatalysts through a sintering-resistant support.