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Showing 1–10 of 10 results
Advanced filters: Author: Xinxian Deng Clear advanced filters

  • Programmed reactivation of the inactive X chromosome in mammals happens in female primordial germ cells (PGCs) to prepare for meiosis and the generation of haploid germ cells that contain a single active X chromosome. Two recent publications clarify the kinetics of X-chromosome reactivation (XCR) in vivo and implicate specific epigenetic modifications in the process.

    • Christine M. Disteche
    • Xinxian Deng
    News & Views
    Nature Structural & Molecular Biology
    Volume: 32, P: 777-779

  • Firre encodes a lncRNA involved in nuclear organization in mammals. Here, the authors find that allelic deletion of Firre on the active X chromosome (Xa) results in dose-dependent loss of histone H3K27me3 on the inactive X chromosome (Xi), along with other trans-acting effects, including disruption of the perinuclear ___location and minor dysregulation of gene expression.

    • He Fang
    • Giancarlo Bonora
    • Christine M. Disteche
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Upregulation of the X chromosome compensates for the presence of a single active X chromosome in mammals, but this has been difficult to measure and to understand mechanistically. A study now demonstrates that increased burst frequency boosts the transcriptional output of X-linked genes in male and female cells with a single active X chromosome. Interestingly, female embryonic stem cells lack increased burst frequency, which is established only after inactivation of the X chromosome takes place; this finding reveals a switch that can modulate transcriptional bursting.

    • Xinxian Deng
    • Christine M. Disteche
    News & Views
    Nature Structural & Molecular Biology
    Volume: 26, P: 851-853

  • Ramani et al. describe a protocol for in situ DNase Hi-C as an alternative to traditional Hi-C methods that use restriction enzymes. The use of DNase I for chromatin digestion circumvents the resolution limit imposed when relying on genomic restriction sites.

    • Vijay Ramani
    • Darren A Cusanovich
    • Zhijun Duan
    Protocols
    Nature Protocols
    Volume: 11, P: 2104-2121

  • The complex mechanisms that regulate the X chromosome lead to evolutionary and physiological variability in gene expression between species, the sexes, individuals, developmental stages, tissues and cell types. This Review discusses the causes and consequences of variability in X-linked gene expression.

    • Xinxian Deng
    • Joel B. Berletch
    • Christine M. Disteche
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 367-378

  • Brian Oliver, Jason Lieb, Christine Disteche and colleagues present an analysis of expression data in mammals, C. elegans and Drosophila. They conclude that dosage compensation corrects the imbalance in the number of X chromosomes relative to autosomes by upregulating X-linked genes in both males and females.

    • Xinxian Deng
    • Joseph B Hiatt
    • Christine M Disteche
    Research
    Nature Genetics
    Volume: 43, P: 1179-1185

  • Single-cell combinatorial indexed Hi-C (sciHi-C) is a streamlined protocol for generating thousands of high-quality single-cell chromosome conformation data sets that resemble bulk Hi-C data in aggregate.

    • Vijay Ramani
    • Xinxian Deng
    • Jay Shendure
    Research
    Nature Methods
    Volume: 14, P: 263-266