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Pressure treatment can modify the luminescence properties of materials. Here the authors use pressure to turn nonemissive organic zinc halide perovskites bright with full color tunability, which enables robust optical anti-counterfeiting applications.

Ma et al. report a regulatory mechanism by which lysine acetylation of the m⁶A reader protein OsECT3 modulates its m⁶A-binding activity under cold stress. The reduced acetylation level stabilizes cold-responsive mRNAs to enhance cold tolerance in rice.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

This work introduces GLORI 2.0 and 3.0, enabling sensitive m⁶A quantification from RNA inputs as low as a few hundred cells.

This study shows how auditory cortex activation and cognitive function develop during a six-month follow-up after gene therapy in children with congenital deafness.

Controlling phase transitions in MoOx semiconductors is challenging. Here, the authors develop a lab-on-device system to modulate proton intercalation, achieving conductance modulation and enabling electrochemical memory and neural network applications.

Lithium metal is the anode of choice for the next-generation high energy density batteries. To address the key technological challenges, the authors report a hybrid Li anode design with hierarchical pores structure derived from natural diatomite and improved electrochemical performance in all-solid-state lithium batteries.

The high cost and low efficiency of current deuteration methods hinder scalable deuteration of organic compounds. Here, the authors report an electrolyser using Pdδ + /NC cathode achieving the deuteration of aldehydes, ketones, imines, and alkenes under solvent-free conditions using pure D2O.

Nodes in a quantum network must be able to interface with photonic qubits as well as perform local quantum computations. The quantum node device presented here is capable of storing quantum information and correcting bit-flip errors.

The realization of active metasurfaces operating in the infrared range remains challenging due to design complexities and scarcity of suitable materials. Here, the authors report the realization of electrically programmable plasmonic metasurfaces integrated with graphene transistors, enabling pixelated thermal emission with low cross-talk and enhanced coherence.

Semisynthetic derivatization approaches to synthesize cyclolignans are limited to using natural sources with inflexible structural features. Now, a powerful, general platform for the synthesis of various types of optically active cyclolignans is achieved through the strategic application of the asymmetric hydrogenation of tetrasubstituted olefins and C(sp³)–H functionalization.

Zwitterionic additives composed of a ‘soft’ organic cation and a ‘hard’ anion enable homogeneous halide cycling in aqueous halide redox flow batteries, resulting in improved cycling life and stability.

Although polymers have been studied for well over a century, there are few examples of covalently linked polymer crystals synthesized directly from solution. Here, the authors demonstrate a strategy to synthesize single crystalline 1D metallo-covalent organic frameworks by combining dynamic covalent chemistry and metal-ligand coordination.

Existing isokinetic training devices are often heavy, bulky, and energy-consuming, which limits the rehabilitation opportunities only at designated hospitals. Here, the authors show a highly integrated and power-free knee rehabilitation robot that can provide home-based isokinetic training

Cycling of the sulfur compound DMSOP by dimethylsulfoniopropionate lyase enzymes in the most abundant marine bacteria, algae and fungi is diverse and prevalent in Earth’s oceans and sediments and probably impacts climate-active gas production.

Dirac semimetals have been proposed as parent materials for other topologically non-trivial phases such as Weyl semimetals, achieved by the breaking of time reversal symmetry. Here the authors use transport measurements to evidence such behaviour in single crystal Cd₃As₂under an applied magnetic field.

The key challenge for rechargeable Ca batteries originates from the severe passivation of the calcium metal anode in electrolyte solutions. Here, the authors demonstrate the feasibility and elucidate the electrochemical properties of calcium-tin (Ca–Sn) alloy anodes for rechargeable Ca batteries.

Analysis of data from the Born in Guangzhou Cohort Study comprising mainly of trios and mother–infant pairs reveals novel East Asian-specific genetic associations with maternal bile acid, gestational weight gain and infant cord blood traits.

Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and an HLA class II locus of significance in high-risk populations. They reanalyze the strength of evidence for previously published risk loci.

Synthesizing functionalized polyethylenes via ethylene coordination copolymerization using vinyl polar monomers is challenging. Here, the authors present an approach utilizing binuclear Ni catalysis for ethylene/acrylamide copolymerization to synthesize cyano-functionalized polyethylenes.

Chip-scale DNA synthesis enables large-scale DNA data storage, but unbiased retrieval remains challenging. Here, authors introduce MPHAC-DIS, an energy-based amplification strategy enabling unbiased, high-accuracy DNA data retrieval, significantly reducing costs and enhancing data accessibility.

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Proteomics can aid in the identification of molecular subtypes in cancers. Here, the authors perform proteomic profiling of 124 paired oesophageal cancer and adjacent non-tumour tissues and identify two subtypes that are associated with patient survival for therapeutic targeting.

The cryo-EM structure of the GSDMB pore reveals mechanisms by which GSDMB pore-forming activity is regulated by pathogenic bacteria and mRNA splicing.

A bottleneck for the application of bioelectrochemical systems is the slow rate of extracellular electron transfer. Here the authors use a synthetic biology approach to redirect metabolic flux to NAD⁺ biosynthesis, which enhances the intracellular electron flux and the extracellular electron transfer rate.

Cryptophytes are ancestral photosynthetic organisms. Here the authors report the cryo-EM structure of the PSII–ACPII from the cryptophyte Chroomonas placoidea, showing that cryptophyte PSII–ACPII consists of a PSII dimer and twelve ACPII monomers that are organised into four linear trimers.

Damaged neural circuits could be improved by generalized BCIs via inputting information into the brains, which is restricted when a large injured cavity caused. Here, the authors construct BCIs mediated by organoid grafts to repair the damaged brain

The high charge doping achieved in ionic field-effect transistors by lithium intercalation allows gate-controlled phase transitions in thin flakes of 1T-TaS₂.

Thermal resistance at interfaces is a critical bottleneck for the thermal management of electronic devices. Here, authors report a high-performance liquid-infused nanostructured composite with thermal resistance under 1 mm² K W⁻¹ and reliability for advanced electronic cooling.

The NF-kB pathway is strictly regulated to prevent excessive inflammatory and immune responses. Here, Li et al. describe an alternative pathway of negative regulation of p65- driven gene expression.