Nobiletin (NOB) has significant neuroprotective effects on retinal ganglion cells (RGCs) in glaucomatous neurodegeneration, including reducing RGC apoptosis and oxidative stress, partially restoring RGC dysfunction, further enhancing Nrf2/HO-1 pathway in RGCs, and attenuating Müller glial activation. These effects do not depend on lowering intraocular pressure. Intervention to enhance activation of Nrf2/HO-1 pathway are viable therapies for glaucoma.
- Dan-Dan Wang
- Feng-Juan Gao
- Ji-Hong Wu