Nature Search

Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes

This study shows that smoking worsens neovascular age-related macular degeneration via the Sema4D-PlexinB1 pathway. Targeting Sema4D reduces choroidal neovascularization and enhances anti-VEGF therapy efficacy, offering a potential therapeutic approach.

Kai He
Xue Dong
Hua Yan
ResearchOpen Access22 Mar 2025
Nature Communications

Volume: 16, P: 1-25
Direct observation of forward-scattering oscillations in the H+HD→H₂+D reaction

Our understanding of reaction dynamics has developed as more accurate measurements of product state-resolved angular distributions have become available. Now, fast forward-scattering oscillations in the product angular distribution of the benchmark chemical reaction H + HD → H₂ + D have been observed and are in excellent agreement with quantum-mechanical dynamics calculations.

Daofu Yuan
Shengrui Yu
Xueming Yang
Research23 Apr 2018
Nature Chemistry

Volume: 10, P: 653-658
Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia

Radial spokes (RS) are crucial in coordinating ciliary motility. Here, authors use cryo-EM and cryo-ET to gain insight into mammalian RS divergence in ependymal cilia, RS assembly mechanism and the structure-function relationships of ciliary and flagellar axonemes.

Xueming Meng
Cong Xu
Yao Cong
ResearchOpen Access08 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Acetylation is required for full activation of the NLRP3 inflammasome

The NLRP3 inflammasome is activated in two steps, priming and assembly, in response to endogenous, microbial, and other environmental danger signals. Here authors show that the assembly step is regulated by acetylation, and inhibition of this post-translational modification prevents full activation of the inflammasome.

Yening Zhang
Ling Luo
Kai Zhao
ResearchOpen Access18 Dec 2023
Nature Communications

Volume: 14, P: 1-12
Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer

Zhu and colleagues identify GREMLIN1 as an FGFR1 ligand that promotes plasticity and castration resistance in prostate cancer through regulation of MAPK signaling, and show that anti-GREMLIN1 antibody therapy synergizes with androgen deprivation.

Chaping Cheng
Jinming Wang
Helen He Zhu
Research27 May 2022
Nature Cancer

Volume: 3, P: 565-580
YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3

YAP is known to play a role both in organ size via the Hippo signalling pathway and in inflammation, though the precise mechanism are unclear. Here, the authors report that YAP promotes activation of the NLRP3 inflammosome through binding interactions.

Dan Wang
Yening Zhang
Kai Zhao
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-14
Structure deformation and curvature sensing of PIEZO1 in lipid membranes

Cryo-electron microscopy structures of PIEZO1 in liposome vesicles in curved and flattened conformations demonstrate the high deformability underlying the high mechanosensitivity and ion selectivity of PIEZO channel gating.

Xuzhong Yang
Chao Lin
Bailong Xiao
Research06 Apr 2022
Nature

Volume: 604, P: 377-383
Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

Cryo-EM analyses of human TRPML3 reveal this channel in three different states—closed, agonist-activated and low-pH-inhibited—and suggest mechanisms for regulation.

Xiaoyuan Zhou
Minghui Li
Jian Yang
Research06 Nov 2017
Nature Structural & Molecular Biology

Volume: 24, P: 1146-1154
Influence of human settlements factors on the spatial distribution patterns of traditional villages in Liaoning province

Guiqiao Tao
Xueming Li
Yishan Song
ResearchOpen Access31 Dec 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-16
Giant enhancement of THz-frequency optical nonlinearity by phonon polariton in ionic crystals

Optical nonlinearity in the THz range is of interest for scientific applications. Here the authors show that THz nonlinearity in ionic crystals can be enhanced by orders of magnitude through phonon polaritons, which is also described by nonlinear modified Huang equations.

Yao Lu
Qi Zhang
Jingjun Xu
ResearchOpen Access26 May 2021
Nature Communications

Volume: 12, P: 1-8
A particle-filter framework for robust cryo-EM 3D reconstruction

A particle-filter algorithm for single-particle cryo-electron microscopy, implemented in a tool called THUNDER, provides high-dimensional parameter estimation, improving the obtainable resolution for several protein structures.

Mingxu Hu
Hongkun Yu
Xueming Li
Research30 Nov 2018
Nature Methods

Volume: 15, P: 1083-1089
Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement

New detector technology has improved the resolution of cryo-electron microscopy (cryo-EM), but tools for structure determination from high-resolution maps have lagged behind. DiMaio et al. report structure determination from high-resolution cryo-EM maps using a homologous structure as a starting model. Also in this issue, Wang et al. describe a de novo approach for structure determination that does not require a starting model.

Frank DiMaio
Yifan Song
David Baker
Research23 Feb 2015
Nature Methods

Volume: 12, P: 361-365
Nucleotide-level Convolutional Neural Networks for Pre-miRNA Classification

Xueming Zheng
Shungao Xu
Xinxiang Huang
ResearchOpen Access24 Jan 2019
Scientific Reports

Volume: 9, P: 1-6
Femtosecond Mode-locked Fiber Laser at 1 μm Via Optical Microfiber Dispersion Management

Lizhen Wang
Peizhen Xu
Limin Tong
ResearchOpen Access16 Mar 2018
Scientific Reports

Volume: 8, P: 1-7
Synthesis of Highly Polymerized Water-soluble Cellulose Acetate by the Side Reaction in Carboxylate Ionic Liquid 1-ethyl-3-methylimidazolium Acetate

Jinhui Pang
Xin Liu
Xueming Zhang
ResearchOpen Access20 Sept 2016
Scientific Reports

Volume: 6, P: 1-9
Simple Approach to Synthesize Amino-Functionalized Carbon Dots by Carbonization of Chitosan

Xin Liu
Jinhui Pang
Xueming Zhang
ResearchOpen Access05 Aug 2016
Scientific Reports

Volume: 6, P: 1-8
Characterizing a new rat model of chronic pain after spine surgery

Qichao Wu
Neil C. Ford
Lei Zang
ResearchOpen Access12 Mar 2025
Bone Research

Volume: 13, P: 1-10
Cryo-EM structures of the ATP-bound Vps4^E233Q hexamer and its complex with Vta1 at near-atomic resolution

The ESCRT-III and Vps4 complexes mediate a variety of membrane remodelling events. Here the authors describe the structure of the Vps4 hexamer complexed to its cofactor Vta1, and show that Vta1 bridges adjacent Vps4 subunits to promote formation of the active hexamer during ESCRT-III filament disassembly.

Shan Sun
Lin Li
Sen-Fang Sui
ResearchOpen Access17 Jul 2017
Nature Communications

Volume: 8, P: 1-13
Structural insights into the secretin translocation channel in the type II secretion system

Cryo-EM structures of secretin GspD in type II secretion systems from Escherichia coli and Vibrio cholera reveal a pentadecameric architecture, with three rings in the periplasm and β-strand-enriched gates on the outer membrane.

Zhaofeng Yan
Meng Yin
Xueming Li
Research09 Jan 2017
Nature Structural & Molecular Biology

Volume: 24, P: 177-183
Effects of poly-γ-glutamic acid (γ-PGA) on plant growth and its distribution in a controlled plant-soil system

Lei Zhang
Xueming Yang
Yuanliang Shi
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
Author Correction: STAT3 promotes NLRP3 inflammasome activation by mediating NLRP3 mitochondrial translocation

Ling Luo
Fupeng Wang
Kai Zhao
Amendments and CorrectionsOpen Access27 Sept 2024
Experimental & Molecular Medicine

Volume: 56, P: 2097
Kaempferol alleviates rheumatoid arthritis through pyroptosis based on bioinformatics analysis and experimental validation

Yi Ling
Nina Ren
Wukai Ma
ResearchOpen Access30 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Sustainable electronic textiles towards scalable commercialization

The commercialization of electronic textile (e-textile) products requires balanced sustainability considerations. Here the authors propose an e-textile design framework involving repair, recycle, replacement and reduction that can unify environmental friendliness, market viability, supply-chain resilience and user experience quality.

HaoTian Harvey Shi
Yifei Pan
Yan Yan Shery Huang
Reviews27 Jul 2023
Nature Materials

Volume: 22, P: 1294-1303
STAT3 promotes NLRP3 inflammasome activation by mediating NLRP3 mitochondrial translocation

Ling Luo
Fupeng Wang
Kai Zhao
ResearchOpen Access02 Sept 2024
Experimental & Molecular Medicine

Volume: 56, P: 1980-1990
N⁶-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors

Zhishuang Gao
Chao Li
Hao Xu
Research17 Dec 2022
Cell Death & Differentiation

Volume: 30, P: 544-559
Flow space reveals the urban network structure and development mode of cities in Liaoning, China

Shenzhen Tian
Jialin Jiang
Chuanglin Fang
ResearchOpen Access29 May 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-17
Correction to: OSR1 phosphorylates the Smad2/3 linker region and induces TGF-β1 autocrine to promote EMT and metastasis in breast cancer

Yang Li
Lei Li
Junming Xu
Amendments and Corrections31 May 2023
Oncogene

Volume: 42, P: 2101
Co-encapsulation of curcumin and quercetin with zein/HP-β-CD conjugates to enhance environmental resistance and antioxidant activity

Chao Qiu
Zhiheng Zhang
Zhengyu Jin
ResearchOpen Access14 Jun 2023
npj Science of Food

Volume: 7, P: 1-10
Cyclodextrin carboxylate improves the stability and activity of nisin in a wider range of application conditions

Yao Hu
Kequan Xing
Chao Qiu
ResearchOpen Access20 May 2023
npj Science of Food

Volume: 7, P: 1-9
OSR1 phosphorylates the Smad2/3 linker region and induces TGF-β1 autocrine to promote EMT and metastasis in breast cancer

Yang Li
Lei Li
Junming Xu
Research13 Oct 2020
Oncogene

Volume: 40, P: 68-84
CryoFIB milling large tissue samples for cryo-electron tomography

Sihan Wang
Heng Zhou
Xueming Li
ResearchOpen Access11 Apr 2023
Scientific Reports

Volume: 13, P: 1-12
Three-dimensional Layered Water-Soluble Cellulose Acetate/Polyacrylamide Composites with Ultrahigh Ductility and Stretchability

Jinhui Pang
Miao Wu
Xueming Zhang
ResearchOpen Access16 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Unraveling variations of crystalline cellulose induced by ionic liquid and their effects on enzymatic hydrolysis

Zhe Ling
Sheng Chen
Feng Xu
ResearchOpen Access31 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect

Demeng Sun
You Yu
Changlin Tian
ResearchOpen Access05 Jun 2018
Cell Discovery

Volume: 4, P: 1-11
Sterilization Effects of Adult-targeted Baits Containing Insect Growth Regulators on Delia antiqua

Fangyuan Zhou
Guodong Zhu
Yanyan Liu
ResearchOpen Access13 Sept 2016
Scientific Reports

Volume: 6, P: 1-9
Cryo-EM structure of Nma111p, a unique HtrA protease composed of two protease domains and four PDZ domains

Li Zhang
Xiaojing Wang
Sen-Fang Sui
Correspondence13 Jan 2017
Cell Research

Volume: 27, P: 582-585
Cryo-EM structure of SNAP-SNARE assembly in 20S particle

Qiang Zhou
Xuan Huang
Sen-Fang Sui
Research24 Apr 2015
Cell Research

Volume: 25, P: 551-560
Mechanisms of bone pain: Progress in research from bench to bedside

Gehua Zhen
Yuhan Fu
Yun Guan
ReviewsOpen Access06 Jun 2022
Bone Research

Volume: 10, P: 1-14

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