Nature Search

A multicenter proof-of-concept study on deep learning-based intraoperative discrimination of primary central nervous system lymphoma

Correct diagnosis of primary central nervous system lymphoma is key in determining treatment, however, this depends on pathology analysis. Here, the authors develop a deep learning method to diagnose primary nervous system lymphoma from stained whole-slide images.

Xinke Zhang
Zihan Zhao
Muyan Cai
ResearchOpen Access04 May 2024
Nature Communications

Volume: 15, P: 1-15
A deep learning model and human-machine fusion for prediction of EBV-associated gastric cancer from histopathology

Epstein–Barr virus-associated gastric cancer shows a robust response to immune checkpoint inhibitors. Here the authors introduce a deep convolutional neural network and its fusion with pathologists for predicting it from histopathology.

Xueyi Zheng
Ruixuan Wang
Muyan Cai
ResearchOpen Access19 May 2022
Nature Communications

Volume: 13, P: 1-12
The hybrid lipoplex induces cytoskeletal rearrangement via autophagy/RhoA signaling pathway for enhanced anticancer gene therapy

Delivering plasmid DNA to solid tumors is challenging since it demands more transport steps than other genetic materials. Here this group designs a hybrid lipoplex for co-delivering p53 plasmid along with MDM2 inhibitor sp141 to hepatocellular carcinoma and lung carcinoma for synergistic anti-tumor treatment.

Xueyi Hu
Yichun Wang
Xintao Shuai
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Cell landscape of larval and adult Xenopus laevis at single-cell resolution

Single-cell RNA sequencing technology offers a unique opportunity to dissect cell heterogeneity of animals. Here, the authors construct a Xenopus cell landscape including larval and adult organs to dissect cell heterogeneity of the amphibian.

Yuan Liao
Lifeng Ma
Xiaoping Han
ResearchOpen Access25 Jul 2022
Nature Communications

Volume: 13, P: 1-15
Deep learning radiomics can predict axillary lymph node status in early-stage breast cancer

Breast cancer is frequently diagnosed using ultrasound. Here, the authors show that, in addition to ultrasound, shear wave elastography can be used to diagnose breast cancer and, in conjunction with deep learning and radiomics, can predict whether the disease has spread to axillary lymph nodes.

Xueyi Zheng
Zhao Yao
Jianhua Zhou
ResearchOpen Access06 Mar 2020
Nature Communications

Volume: 11, P: 1-9
Publisher Correction: Cell landscape of larval and adult Xenopus laevis at single-cell resolution

Yuan Liao
Lifeng Ma
Xiaoping Han
Amendments and CorrectionsOpen Access01 Sept 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Deep learning radiomics can predict axillary lymph node status in early-stage breast cancer

Xueyi Zheng
Zhao Yao
Jianhua Zhou
Amendments and CorrectionsOpen Access12 Jul 2021
Nature Communications

Volume: 12, P: 1
Single-cell multiplex chromatin and RNA interactions in ageing human brain

We introduce multinucleic acid interaction mapping in single cells (MUSIC), for concurrent profiling of multiplex chromatin interactions, gene expression and RNA–chromatin associations within individual nuclei, as a tool for exploring chromatin architecture and transcription.

Xingzhao Wen
Zhifei Luo
Sheng Zhong
ResearchOpen Access27 Mar 2024
Nature

Volume: 628, P: 648-656
Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, blood protein markers of brain health are integrated with omics data to reveal DNA methylation differences that associate with these protein markers.

Danni A. Gadd
Robert F. Hillary
Riccardo E. Marioni
ResearchOpen Access09 Aug 2022
Nature Communications

Volume: 13, P: 1-14
Hierarchical Li electrochemistry using alloy-type anode for high-energy-density Li metal batteries

Utilizing an ultra-thin Li anode with a thickness below 50 μm is crucial for enhancing the energy density of batteries. Here, the authors develop a finely tunable, thin alloy-based Li anode that features a hierarchical Li electrochemistry, enabling stable cycling and superior energy density in Li metal batteries.

Jiaqi Cao
Yuansheng Shi
Xia Lu
ResearchOpen Access14 Feb 2024
Nature Communications

Volume: 15, P: 1-13
Slight compositional variation-induced structural disorder-to-order transition enables fast Na⁺ storage in layered transition metal oxides

In layered transition metal oxides as cathode active materials for Na-ion batteries, Na⁺ diffusion kinetics are impacted by Na⁺/vacancy ordering. Here, the authors suggest that the P2-type Na_2/3Ni_1/3Mn_2/3O₂ with large zigzag ordering exhibits high Na⁺ mobility and thus superior rate capability.

Yuansheng Shi
Pengfeng Jiang
Xia Lu
ResearchOpen Access22 Dec 2022
Nature Communications

Volume: 13, P: 1-12
Deep learning of cross-species single-cell landscapes identifies conserved regulatory programs underlying cell types

Microwell-seq is used to generate single-cell, whole-body expression landscapes of zebrafish, Drosophila and earthworm. A deep-learning model, Nvwa, predicts gene expression from DNA sequence and identifies regulatory programs shared across eight species.

Jiaqi Li
Jingjing Wang
Guoji Guo
Research13 Oct 2022
Nature Genetics

Volume: 54, P: 1711-1720
Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3

Oxygen is an essential requirement for aerobic organisms. Here the authors explore the role of oxygen in the antiviral innate response in multiple models of infection and suggest oxygen enhances the antiviral innate response via EGLN1 hydroxylation of IRF3.

Xing Liu
Jinhua Tang
Wuhan Xiao
ResearchOpen Access26 Apr 2024
Nature Communications

Volume: 15, P: 1-21
Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH

Signal amplification through hybridization chain reaction by targeting conserved regions of the M13mp18 bacteriophage-based scaffold sequences is used for in situ imaging of unlabelled DNA origami nanostructures.

Wendy Xueyi Wang
Travis R. Douglas
Leo Y. T. Chou
Research27 Jul 2023
Nature Nanotechnology

Volume: 19, P: 58-69
Experimental and numerical investigation of the water-entry behavior of an inverted T-shaped beam

Xueyi Li
Feidong Zheng
ResearchOpen Access26 Nov 2024
Scientific Reports

Volume: 14, P: 1-15
Steroid metabolism gene variants and their genotype-phenotype correlations in Chinese early-onset hypertension patients

Fang Qin
Kai Liu
Lei Song
Research06 Aug 2019
Hypertension Research

Volume: 42, P: 1536-1543
Author Correction: Sparse whole-genome sequencing identifies two loci for major depressive disorder

N. A. Cai
Tim B. Bigdeli
Jonathan Flint
Amendments and Corrections11 Aug 2023
Nature

Volume: 620, P: E28
Prognostic Value of Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma: a Meta-analysis

Zhaona Fan
Mianxiang Li
Juan Xia
ResearchOpen Access21 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Sparse whole-genome sequencing identifies two loci for major depressive disorder

Genomic analysis of 5,303 Chinese women with recurrent major depressive disorder (MDD) enables the identification and replication of two genome-wide significant loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene; the other in an intron of the LHPP gene.

Na Cai
Tim B. Bigdeli
Jonathan Flint
Research15 Jul 2015
Nature

Volume: 523, P: 588-591
HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma

Junying Sun
Baocun Sun
Danfang Zhang
ResearchOpen Access22 May 2017
Scientific Reports

Volume: 7, P: 1-13
Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Sanjay Jain
Liming Pei
Michael P. Snyder
Amendments and Corrections01 Mar 2024
Nature Cell Biology

Volume: 26, P: 839
S1PR1 regulates the switch of two angiogenic modes by VE-cadherin phosphorylation in breast cancer

Shuang Liu
Chunsheng Ni
Baocun Sun
ResearchOpen Access27 Feb 2019
Cell Death & Disease

Volume: 10, P: 1-15
miR-27a-3p suppresses tumor metastasis and VM by down-regulating VE-cadherin expression and inhibiting EMT: an essential role for Twist-1 in HCC

Nan Zhao
Huizhi Sun
Xiao Li
ResearchOpen Access16 Mar 2016
Scientific Reports

Volume: 6, P: 1-16
Nitrogen and boron doped carbon layer coated multiwall carbon nanotubes as high performance anode materials for lithium ion batteries

Bo Liu
Xiaolei Sun
Guang-Ping Hao
ResearchOpen Access11 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

Sanjay Jain
Liming Pei
Michael P. Snyder
Reviews19 Jul 2023
Nature Cell Biology

Volume: 25, P: 1089-1100
Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage

Xing Liu
Fangjing Rong
Wuhan Xiao
Research12 Oct 2021
Cell Death & Differentiation

Volume: 29, P: 722-736
OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation

Xing Liu
Hongyan Deng
Wuhan Xiao
ResearchOpen Access22 Jun 2022
Cell Death & Disease

Volume: 13, P: 1-12
Epigenetic prediction of major depressive disorder

Miruna C. Barbu
Xueyi Shen
Andrew M. McIntosh
ResearchOpen Access10 Jun 2020
Molecular Psychiatry

Volume: 26, P: 5112-5123
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions

Min Tang
Qi Xie
Jeremy N. Rich
Research04 Jun 2020
Cell Research

Volume: 30, P: 833-853

Search

A multicenter proof-of-concept study on deep learning-based intraoperative discrimination of primary central nervous system lymphoma

A deep learning model and human-machine fusion for prediction of EBV-associated gastric cancer from histopathology

The hybrid lipoplex induces cytoskeletal rearrangement via autophagy/RhoA signaling pathway for enhanced anticancer gene therapy

Cell landscape of larval and adult Xenopus laevis at single-cell resolution

Deep learning radiomics can predict axillary lymph node status in early-stage breast cancer

Publisher Correction: Cell landscape of larval and adult Xenopus laevis at single-cell resolution

Author Correction: Deep learning radiomics can predict axillary lymph node status in early-stage breast cancer

Single-cell multiplex chromatin and RNA interactions in ageing human brain

Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

Hierarchical Li electrochemistry using alloy-type anode for high-energy-density Li metal batteries

Slight compositional variation-induced structural disorder-to-order transition enables fast Na⁺ storage in layered transition metal oxides

Deep learning of cross-species single-cell landscapes identifies conserved regulatory programs underlying cell types

Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3

Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH

Experimental and numerical investigation of the water-entry behavior of an inverted T-shaped beam

Steroid metabolism gene variants and their genotype-phenotype correlations in Chinese early-onset hypertension patients

Author Correction: Sparse whole-genome sequencing identifies two loci for major depressive disorder

Prognostic Value of Cancer Stem Cell Markers in Head and Neck Squamous Cell Carcinoma: a Meta-analysis

Sparse whole-genome sequencing identifies two loci for major depressive disorder

HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma

Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

S1PR1 regulates the switch of two angiogenic modes by VE-cadherin phosphorylation in breast cancer

miR-27a-3p suppresses tumor metastasis and VM by down-regulating VE-cadherin expression and inhibiting EMT: an essential role for Twist-1 in HCC

Nitrogen and boron doped carbon layer coated multiwall carbon nanotubes as high performance anode materials for lithium ion batteries

Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage

OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation

Epigenetic prediction of major depressive disorder

Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions

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