Nature Search

Efficacy and safety of JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone: a multicenter, phase Ib/II study

Giant cell tumor of bone (GCTB) is a rare primary osteolytic bone tumor with high local recurrence rate after surgical resection. Here the authors conduct a phase Ib/II trial, evaluating the efficacy and safety of JMT103 (RANK-RANKL inhibitor) in patients with unresectable or surgically-challenging GCTB.

Hairong Xu
Yong Zhou
Xiaohui Niu
ResearchOpen Access05 Nov 2024
Nature Communications

Volume: 15, P: 1-9
Stress increases hepatic release of lipocalin 2 which contributes to anxiety-like behavior in mice

Cross talk between periphery and the central nervous system may contribute to stress associated behaviours. Here the authors identified liver-derived lipocalin 2 as a peripheral factor that elicits anxiety-like behaviours via modulating medial prefrontal neural activity.

Lan Yan
Fengzhen Yang
Li Zhang
ResearchOpen Access08 Apr 2024
Nature Communications

Volume: 15, P: 1-16
Angle-programmed tendril-like trajectories enable a multifunctional gripper with ultradelicacy, ultrastrength, and ultraprecision

Soft grippers can emulate human hands, but it remains challenging to achieve multiple capability in manipulating various objects in one design. Hong et al. utilize a kirigami gripper with controllable and programmable trajectories to manipulate objects spanning from ultra-soft to ultra-strong with high precision.

Yaoye Hong
Yao Zhao
Jie Yin
ResearchOpen Access02 Aug 2023
Nature Communications

Volume: 14, P: 1-10
Oscillatory solvation chemistry for a 500 Wh kg⁻¹ Li-metal pouch cell

Cation solvation in batteries is well understood in bulk solutions but less so at electrode/electrolyte interfaces. This study reveals how external and intramolecular fields affect Li-ion solvation, proposing a dielectric protocol to enhance cation–anion coordination and improve performance in Li-metal pouch cells.

Shuoqing Zhang
Ruhong Li
Xiulin Fan
Research22 Aug 2024
Nature Energy

Volume: 9, P: 1285-1296
A genomic variation map provides insights into peanut diversity in China and associations with 28 agronomic traits

Resequencing of 390 peanut accessions provides insights into peanut migration and diversity in China. Genome-wide association analysis identifies loci associated with 28 agronomic traits.

Qing Lu
Lu Huang
Xiaoping Chen
Research20 Feb 2024
Nature Genetics

Volume: 56, P: 530-540
Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase

Hong Yu, Yanbin Niu, Guohua Jia et al. integrate in vitro, in vivo, and human experiments to examine a link between RORA expression on autism-like behavior. Their results suggest that maternal diabetes may contribute to autism-like behavior via RORA suppression.

Hong Yu
Yanbin Niu
Paul Yao
ResearchOpen Access13 Jan 2022
Communications Biology

Volume: 5, P: 1-16
Boundary curvature guided programmable shape-morphing kirigami sheets

Kirigami, a traditional paper cutting art, offers a promising strategy for 2D-to-3D shape morphing through cut-guided deformation. Here, authors report a simple strategy of cut boundary curvature-guided 3D shape morphing and its applications in non-destructive grippers and dynamically conformable heaters.

Yaoye Hong
Yinding Chi
Jie Yin
ResearchOpen Access26 Jan 2022
Nature Communications

Volume: 13, P: 1-13
Robust ultraclean atomically thin membranes for atomic-resolution electron microscopy

High-resolution electron microscopy requires robust and noise-free substrates to support the specimens. Here, the authors present a polymer- and transfer-free direct-etching method for fabrication of graphene grids with ultraclean surfaces and demonstrate cryo-EM at record high resolution.

Liming Zheng
Yanan Chen
Hailin Peng
ResearchOpen Access28 Jan 2020
Nature Communications

Volume: 11, P: 1-8
The Kalanchoë genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism

Crassulacean acid metabolism (CAM) is a metabolic adaptation of photosynthesis that enhances water use efficiency. Here, via genomic analysis of Kalanchoë, the authors provide evidence for convergent evolution of protein sequence and temporal gene expression underpinning the multiple independent emergences of CAM.

Xiaohan Yang
Rongbin Hu
Gerald A. Tuskan
ResearchOpen Access01 Dec 2017
Nature Communications

Volume: 8, P: 1-15
Gut proinflammatory bacteria is associated with abnormal functional connectivity of hippocampus in unmedicated patients with major depressive disorder

Shu Xiao
Zibin Yang
Ying Wang
ResearchOpen Access16 Jul 2024
Translational Psychiatry

Volume: 14, P: 1-10
Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

MG53 acts as an E3 ligase that targets the insulin receptor and IRS1 for ubiquitin-dependent degradation; when MG53 is upregulated, metabolic syndrome ensues.

Ruisheng Song
Wei Peng
Rui-Ping Xiao
Research27 Jan 2013
Nature

Volume: 494, P: 375-379
Probing the communication patterns of different chondrocyte subtypes in osteoarthritis at the single cell level using pattern recognition and manifold learning

Jiajian Wang
Caihong Liu
Ruihuan Xu
ResearchOpen Access02 Sept 2023
Scientific Reports

Volume: 13, P: 1-10
Grassland changes and adaptive management on the Qinghai–Tibetan Plateau

Climate change and anthropogenic activities are altering grasslands on the Qinghai–Tibetan Plateau. This Review examines vegetation and soil changes, and the role of various drivers in affecting them.

Yanfen Wang
Wangwang Lv
Haishan Niu
Reviews06 Sept 2022
Nature Reviews Earth & Environment

Volume: 3, P: 668-683
Author Correction: Identification of urine protein biomarkers with the potential for early detection of lung cancer

Hongjuan Zhang
Jing Cao
Liang Chen
Amendments and CorrectionsOpen Access28 Sept 2018
Scientific Reports

Volume: 8, P: 1
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Georg B. Ehret
Patricia B. Munroe
Toby Johnson
Research11 Sept 2011
Nature

Volume: 478, P: 103-109
Identification of urine protein biomarkers with the potential for early detection of lung cancer

Hongjuan Zhang
Jing Cao
Liang Chen
ResearchOpen Access02 Jul 2015
Scientific Reports

Volume: 5, P: 1-13
A microfluidic device for studying chemotaxis mechanism of bacterial cancer targeting

Jing Song
Yu Zhang
Qi Wang
ResearchOpen Access23 Apr 2018
Scientific Reports

Volume: 8, P: 1-9
Runx2-Modified Adipose-Derived Stem Cells Promote Tendon Graft Integration in Anterior Cruciate Ligament Reconstruction

Xin Zhang
Yong Ma
Yingfang Ao
ResearchOpen Access08 Jan 2016
Scientific Reports

Volume: 6, P: 1-15
Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective

Yanbin Zhao
Kun Zhang
Jianying Hu
ResearchOpen Access25 Feb 2015
Scientific Reports

Volume: 5, P: 1-9
Development and validation of a predictive nomogram for preoperative deep vein thrombosis (DVT) in isolated calcaneal fracture

Xinqun Cheng
Xiang Lei
Jincheng Yan
ResearchOpen Access08 Apr 2022
Scientific Reports

Volume: 12, P: 1-10
Global transcriptome analysis of subterranean pod and seed in peanut (Arachis hypogaea L.) unravels the complexity of fruit development under dark condition

Hao Liu
Xuanqiang Liang
Xiaoping Chen
ResearchOpen Access03 Aug 2020
Scientific Reports

Volume: 10, P: 1-12
Long noncoding RNA lncAIS downregulation in mesenchymal stem cells is implicated in the pathogenesis of adolescent idiopathic scoliosis

Qianyu Zhuang
Buqing Ye
Jianguo Zhang
Research21 Nov 2018
Cell Death & Differentiation

Volume: 26, P: 1700-1715
Dynamic Expression Profile, Regulatory Mechanism and Correlation with Egg-laying Performance of ACSF Gene Family in Chicken (Gallus gallus)

Weihua Tian
Hang Zheng
Xiaojun Liu
ResearchOpen Access31 May 2018
Scientific Reports

Volume: 8, P: 1-10
Evolution, dynamic expression changes and regulatory characteristics of gene families involved in the glycerophosphate pathway of triglyceride synthesis in chicken (Gallus gallus)

Liyu Yang
Ziming Liu
Xiaojun Liu
ResearchOpen Access04 Sept 2019
Scientific Reports

Volume: 9, P: 1-9
Ultrahard stitching of nanotwinned diamond and cubic boron nitride in C₂-BN composite

Xiaobing Liu
Xin Chen
Steven D. Jacobsen
ResearchOpen Access27 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
Expression of Thyroid Hormone Responsive SPOT 14 Gene Is Regulated by Estrogen in Chicken (Gallus gallus)

Junxiao Ren
Naiyi Xu
Xiaojun Liu
ResearchOpen Access31 Aug 2017
Scientific Reports

Volume: 7, P: 1-10

Search

Efficacy and safety of JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone: a multicenter, phase Ib/II study

Stress increases hepatic release of lipocalin 2 which contributes to anxiety-like behavior in mice

Angle-programmed tendril-like trajectories enable a multifunctional gripper with ultradelicacy, ultrastrength, and ultraprecision

Oscillatory solvation chemistry for a 500 Wh kg⁻¹ Li-metal pouch cell

A genomic variation map provides insights into peanut diversity in China and associations with 28 agronomic traits

Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase

Boundary curvature guided programmable shape-morphing kirigami sheets

Robust ultraclean atomically thin membranes for atomic-resolution electron microscopy

The Kalanchoë genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism

Gut proinflammatory bacteria is associated with abnormal functional connectivity of hippocampus in unmedicated patients with major depressive disorder

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

Probing the communication patterns of different chondrocyte subtypes in osteoarthritis at the single cell level using pattern recognition and manifold learning

Grassland changes and adaptive management on the Qinghai–Tibetan Plateau

Author Correction: Identification of urine protein biomarkers with the potential for early detection of lung cancer

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Identification of urine protein biomarkers with the potential for early detection of lung cancer

A microfluidic device for studying chemotaxis mechanism of bacterial cancer targeting

Runx2-Modified Adipose-Derived Stem Cells Promote Tendon Graft Integration in Anterior Cruciate Ligament Reconstruction

Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective

Development and validation of a predictive nomogram for preoperative deep vein thrombosis (DVT) in isolated calcaneal fracture

Global transcriptome analysis of subterranean pod and seed in peanut (Arachis hypogaea L.) unravels the complexity of fruit development under dark condition

Long noncoding RNA lncAIS downregulation in mesenchymal stem cells is implicated in the pathogenesis of adolescent idiopathic scoliosis

Dynamic Expression Profile, Regulatory Mechanism and Correlation with Egg-laying Performance of ACSF Gene Family in Chicken (Gallus gallus)

Evolution, dynamic expression changes and regulatory characteristics of gene families involved in the glycerophosphate pathway of triglyceride synthesis in chicken (Gallus gallus)

Ultrahard stitching of nanotwinned diamond and cubic boron nitride in C₂-BN composite

Expression of Thyroid Hormone Responsive SPOT 14 Gene Is Regulated by Estrogen in Chicken (Gallus gallus)

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