d-Serine is needed for glutamate-induced epileptic seizures. Sha and Wang et al. found that l-serine produced by astrocytes positively correlates with d-serine level in neurons and identified a small molecule that suppresses seizures in animal models of epilepsy by inhibiting phosphoserine phosphatase, a key enzyme for l-serine synthesis.
- Longze Sha
- Yanbing Wang
- Qi Xu
