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In this work the authors present Token-Mol, a token-only 3D drug design model, which deploys the Gaussian cross-entropy (GCE) loss function for regression tasks. It exhibits superior performance in molecular conformation generation, property prediction, and pocket-based generation, thus opening up new avenues for drug design.

H₂O₂ is a commodity chemical produced in industry via the anthraquinone process from H₂ and O₂. Now a heterogeneous catalysis approach is presented in which H₂O₂ is synthesized from H₂O and O₂ on defective SnSe nanosheets at ambient conditions.

Here, authors develop an in-memory differentiator using a 40×40 array of ferroelectric capacitors. This device efficiently performs real-time differential computation and motion extraction, demonstrating low energy consumption and high operational frequency, with potential applications in edge computing.

Spin injection in pure topological surface states of topological insulators is challenging due to the coexistence of highly conducting bulk states. Here, Song et al. report spin injection and inverse Edelstein effect in the spin–momentum locked surface states of topological Kondo insulator SmB₆.

Iron oxide nanoparticles (IONP) are approved to treat iron deficiency and have been reported to reduce leukaemia in preclinical models. Here, the authors show that carboxymethyl dextran-coated IONP, but not other types of surface coating, activate the complement alternative pathway, enhancing macrophage phagocytosis and adaptive immunity to reduce leukaemia burden in mouse models.

Chromosome-level genome assemblies of allotetraploid Nicotiana tabacum and its ancestors, along with their transcriptomes, epigenomes and genotype and phenotype data for 5,196 N. tabacum germplasms, provide insights into genome evolution and complex trait regulation.

The device performance of organic light-emitting diodes has been hampered by the low power efficiency at high luminance. Here, authors employ a thermally activated delayed fluorescence sensitizing host, achieving maximum power efficiency close to 190 lm/W and maximum luminance of over 110,000 cd/m2.

Treatments for Alzheimer’s disease (AD) remain limited. Here, the authors show that 40 hertz blue light activates a visual circuit to boost glymphatic drainage, and enhances memory, motivation, and anti-Aβ therapy efficacy in a mouse model of AD.

Chlor-alkali process plays an important role in the chemical industry. However, large overpotential and low selectivity of currently used catalysts lead to high energy consumption. Here the authors report Ru-O₄ single site catalysts for chlorination evolution with 1000 h stability at 1000 mA cm⁻² in a seawater-like environment.

Analysis of 43,191 genomes obtained from publicly available marine bacterial and archaeal metagenome data provides insights into marine bacterial evolution, CRISPR–Cas defence and antibiotic resistance genes, and demonstrates the potential of marine metagenomes for biotechnological applications.

In response to the rebound of air pollution during large events in China, the authors propose that a combination of ambitious short-term measures and enduring long-term pollution control policies is a sustainable solution for improving air quality.

CCLMoff is a deep learning framework that leverages RNA language modeling for accurate CRISPR/Cas9 off-target prediction, demonstrating strong generalization across datasets and advancing computational sgRNA design.

Pulse enhanced weathering of trans-Gondwanan super mountains during the Ediacaran Shuram carbon isotope excursion, potentially increased nutrient inputs in the ocean which resulted in transient oceanic oxygenation, according to dynamic box modeling, geochemistry data, and Li isotope composition analysis of carbonate Ediacaran sections in south China.

Field-effect transistors that use carbon nanotubes as the channel material and an ion gel as the gate exhibit a high tolerance to radiation and can be recovered following radiation damage using a simple annealing process.

The molecular mechanisms underlying relapse in pediatric B-lineage acute lymphoblastic leukemia (B-ALL) patients remain to be explored. Here, the authors characterise the chromatin accessibility landscape of B-ALL and identify subtype and drug response specific patterns.

Atomic-level coordination influences the properties of single-atom-catalysts but is difficult to precisely engineer. Here, authors study the role of local symmetry manipulation, finding planar-symmetry-broken CuN₃ catalysts outperform highly symmetrical CuN₄ for CO₂ electroreduction to formic acid.

Controlling the ketoenamine-enolimine tautomerism and correlating their structure to photoelectronic properties remains challenging in organic solids. Here, the authors show tautomerization in a crystalline dynamic 3D covalent organic framework (dynaCOF) through host-guest interactions leading to reversible framework deformation accompanied by chromic effects which can be used in chemosensing.

Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcome by inhibitors of purine synthesis.

Adipose tissue-resident regulatory T (T_reg) cells are important for maintaining normal metabolic function and adiposity. Li and colleagues demonstrate that insulin signaling directly controls adipose T_reg cell development and functionality

Triggering the PD-1/PD-L1 immune checkpoint is an attractive therapeutic approach in inflammatory bowel disease, and PD-L1, conjugated to the Fc part of an immunoglobulin (PD-L1-Fc) has been shown to be effective in mouse models. Here authors show that fusing to reactive oxygen species (ROS)-responsive nanoparticles improves effect of PD-L1-Fc due to targeting to inflammation sites, while systemic toxicity is reduced.

Egg-laying performance is an important phenotype for breeding chicken. Here, the authors explore the regulatory networks driving phenotypic differences in egg-laying, and identify laying-related variants and endocrine factors.

By tracing promoter expression in lineage-mapped single cells, Xu et al. present a whole-body cartography of microRNA transcriptional activities during C. elegans embryogenesis and demonstrate its broad utility in multifaceted functional analyses.

Ferroelectric HfO₂ is faced with an oxygen vacancy dilemma, which favors the polar phase but harm to switching behaviors. Here, the authors propose a donor-acceptor co-doping method to enhance polarization switching characteristics of the HfO₂ films.

Migratory cross-coupling reactions are powerful tools to form bonds at predictable positions. Here the authors report a nickel-catalyzed migratory Suzuki–Miyaura cross-coupling of unactivated alkyl electrophiles with aryl and vinyl boron reagents and provide experimental and computational mechanistic evidence.

Dispersionless plasmons could find important practical applications, but previous demonstrations have been limited to 2D materials and small momentum range. Here the authors report ultra-flat plasmons propagating over a wide range of momenta in a 3D strongly correlated oxide α-Ti₂O₃.

Successive fusion of yeast chromosomes is used to produce a single-chromosome strain that is viable, albeit with slightly reduced fitness.

‘Thermosets are ubiquitous but existing manufacturing of thermosets involves either a prolonged manufacturing cycle, low geometric complexity, or limited processable materials. Here, the authors report an in situ dual heating strategy for the rapid 3D printing of thermosets with complex structures and diverse rheological properties by incorporating direct ink writing (DIW) technique and a heating-accelerated in situ gelation mechanism

Conventionally, urea is synthesized via two consecutive processes, N₂ + H₂ → NH₃ followed by NH₃ + CO₂. Now, an electrocatalyst consisting of PdCu alloy nanoparticles on TiO₂ nanosheets has been shown to directly couple N₂ and CO₂ in H₂O to produce urea under ambient conditions.

The mechanisms behind the oncogenic role of the PIK3CA helical ___domain mutant is poorly understood. Here, the authors show that its oncogenic function depends on the release of p85β from mutated p110α, its translocation to the nucleus and the consequent increased activity of EZH proteins.

Biochemical and structural studies of the interactions between antibodies and spike proteins from SARS-CoV-2 Omicron subvariants indicate how these variants have evolved to escape antibody-mediated neutralization.

Whether connectivity in white matter detected by functional MRI relates to underlying electrophysiological synchronization is unclear. Here, the authors show that blood-oxygenation-level-dependent (BOLD) functional connectivity and intracranial stereotactic-electroencephalography (SEEG) connectivity are correlated across a wide range of frequency bands.

Ticks are an important vector of disease in China, posing threats to humans, livestock and wild animals. Here, Zhao et al. compile a database of the distributions of the 124 tick species known in China and 103 tick-borne pathogens and predict the additional suitable habitats for the predominant vector species.

The mechanisms underlying sex differences in response to stress are unclear. Here, the authors show that meningeal lymphatics dysfunction modulates the sex difference in the stress susceptibility to depression- and anxiety-like behaviours in mice.

HARP are member of protein-only RNase P, which catalyzes pre-tRNA 5’-end processing and maturation. Here, the authors present crystal structure and provide mechanistic insights into pre-tRNA binding and cleavage by HARP proteins.

Upstream pathways regulating Brg1 stability and their role in carcinogenesis are unknown. Here they show Brg1 to be phosphorylated by CK1δ to promote its ubiquitination by SCF^FBW7 (FBW7), Brg1 stabilization to promote gastric cancer metastasis, and suggest targeting Brg1 in FBW7 compromised gastric cancer.

Oxidants currently used in the preparation of graphene oxide (GO) require long reaction times, relatively high temperatures and costly waste treatment. Here, the authors propose the use of a strong green oxidant, K2FeO4, establishing a fast, safe, toxicity-free route to GO production.