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As a major source of reactive oxygen species, mitochondria face a challenge to maintain their redox state. Here the authors show that ROMO1 overexpression prevents deleterious oxidation of the mitochondrial cysteinome and exerts beneficial effects on mitochondrial function.

Veratramine and cyclopamine are valuable molecules in agricultural and medicinal chemistry, but the efficient chemical synthesis approaches are in high demand. Here, the authors report the concise, divergent, and scalable syntheses of veratramine and cyclopamine with 11% and 6.2% overall yield, respectively.

An isolation strategy is presented to improve the stability of metal nanoparticles by grafting oxide nano-islands between the support and the nanoparticles. This enhances sintering resistance, with the mean size of the nanoparticles maintained at 1.4 nm after 400 h of catalytic dry reforming of methane.

The mechanisms allowing early disseminated cancer cells colonize other tissues remain largely unknown. Here, authors show that GPRC5A axis drives esophageal squamous cell carcinoma lung seeding and metastasis, in a mechanism resembling trophoblast behavior during embryo implantation.

Hydrogel-based flexible sensors have potential in a number of fields, but mechanical properties can be compromised as a result of water evaporation. Here, the authors report a method for limiting of water loss by addition of a lipid-based coating to the surface of the hydrogel.

This study identifies PPKs as authentic protein kinases phosphorylating the far-red light photoreceptor phytochrome A and demonstrates that liquid–liquid phase separation of TZP promotes PPK-mediated phosphorylation of phytochrome A in far-red light.

In a randomized, double-blind, placebo-controlled phase 3 trial, the anti-vascular endothelial growth factor receptor small-molecule inhibitor fruquintinib plus chemotherapy significantly extended progression-free survival, but not overall survival, as second-line therapy in patients with advanced gastric or gastroesophageal junction cancers.

Whole-genome sequencing of 175 Mongolians representing six tribes highlights population-specific genetic architecture and substantial gene flow among northern Eurasian populations, including derived alleles shared by Mongolians and Finns.

Neurons in the dorsal motor nucleus of vagus are involved in the absorption of fat in the intestine, and the natural compound puerarin shows utility in modulating this brain–gut axis to reduce fat absorption.

High-quality genomes of two cultivated tetraploid cottons Gossypium hirsutum cv. NDM8 and Gossypium barbadense acc. Pima90 and resequencing of 1,081 G. hirsutum accessions provide insights into the role of structural variations.

In the largest study so far of CAR T cells in patients with solid tumors, autologous CLDN18.2-targeting CAR T cell therapy was well tolerated in patients with advanced CLDN18.2-positive gastrointestinal cancers, with an overall response rate of 42.2% and a disease control rate of 91.1%.

Soft conducting polymer electrodes allowing for the continuous and precise localization of a target nerve during microsurgeries led to improved post-operative prognoses after tumour-resection surgeries in rats.

Comparative genomics can provide valuable insights on adaptations to hostile environments. Here, the authors sequence the genomes and transcriptomes of the Bactrian camel, dromedary and alpaca, to reveal the demographic history of the group as well as metabolic adaptations to the desert environment.

Single-cell transcriptome profiling of human aneuploid blastocysts highlights global transcriptomic alteration and identifies novel dosage-sensitive genes in aneuploidy. Aneuploid embryos undergo unstable epiblast maturation caused by defects in the TGF-β and FGF pathways that impact trophectoderm progression.

Superconducting interfaces involving KTaO3 have recently attracted attention due to their relatively high transition temperature. Here, the authors study amorphous-YAlO₃/KTaO₃ interfaces and find two-fold symmetry in the superconducting regime, possibly due to a mixed-parity superconducting state.

In an interim analysis of a phase 1 trial, CAR T cells specific for Claudin18.2, a tight junction protein isoform highly expressed on gastrointestinal tract tumors, were well-tolerated and exhibited promising clinical activity in patients with gastrointestinal cancers.

 A method for topological automatic cell type classification across subcellular resolution spatial transcriptomic platforms is proposed, resolving cell type information and locating sparsely dispersed cells in human kidney and mouse kidney and brain.

Although the role of FGFs in cardiovascular disease has attracted extensive attention, the potential role of FGF18 in pathological cardiac hypertrophy remains unknown. Here, the authors show the cardioprotective effect of FGF18 is mediated by maintaining redox homeostasis through FYN/Nox4 signaling.

Norepinephrine neurons, a drug target for neurologic diseases, are produced from stem cells.

Soft robots are challenging to model and program. Non-specialists face non-negligible obstacles when working with soft robots to perform tasks. Here, the authors propose a method to interactively teach soft robots complex motions through flexible touchless and tactile multimodal sensors.

Catecholaminergic transmitters are critical signalling effectors known to be released by sympathetic nerves and adrenomedullary endocrine cells in response to physiological stress. In this paper, the authors demonstrate a uniquely distributed group of catecholaminergic cardiomyocytes with key regulatory roles in cardiac excitation conduction.

Cytokinin is essential for regulation of nodulation. Here, the authors identified a B-type response regulator GmRR11d that governs a transcriptional program associated with nodulation and cytokinin activation essential for systemic regulation of nodulation.

Obesity is associated with inflammation in adipose tissue, characterized by a shift in local T cell subsets. Here the authors show that loss of MHCII expression on adipocytes increases levels of immunosuppressive regulatory T cells in adipose tissue, which enhances insulin sensitivity.

Sequencing of over 600 genes in a large collection of lung adenocarcinoma samples provides an overview of somatic mutations and signalling pathways altered in cancer genes in this tumour type.

Observation of migrasomes in glioblastoma (GBM) and analysis of migrasome-enriched proteins revealed that migrasomes promote GBM migration and invasion by releasing the extracellular matrix-associated proteins PAK4 and LAMA4.

With a comprehensive analysis of sequencing data, DNA copy number, gene expression and DNA methylation in a large number of human glioblastomas, The Cancer Genome Atlas project initiative provides a broad overview of the genes and pathways that are altered in this cancer type.

UCSCXenaShiny integrates multidimensional data for robust and personalized pan-cancer analysis pipelines, enabling in-depth cancer data exploration in diverse scenarios.