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Deep learning-enabled assessment of cardiac allograft rejection from endomyocardial biopsies

Deep learning applied to endomyocardial biopsy images, developed using datasets from three different countries, can detect rejection of transplanted hearts and determine the subtype and grade of rejection, with potential for reducing the interobserver variability inherent in manual interpretation of these biopsies.

Jana Lipkova
Tiffany Y. Chen
Faisal Mahmood
Research21 Mar 2022
Nature Medicine

Volume: 28, P: 575-582
TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis

TREM-1 is a receptor that amplifies acute pro-inflammatory responses in infection. Here the authors show that TREM-1 plays an important role in atherosclerosis, a chronic and non-infectious disease, by critically skewing myelopoiesis towards preferential monocyte differentiation and by contributing to CD36-driven cellular lipid accumulation.

Daniel Zysset
Benjamin Weber
Christoph Mueller
ResearchOpen Access20 Oct 2016
Nature Communications

Volume: 7, P: 1-16
Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents

A phase 1 dose-escalating trial evaluating CD70 inhibition in combination with hypomethylating therapy results in the elimination of leukemia stem cells and achieves clinical activity in untreated patients with acute myeloid leukemia.

Carsten Riether
Thomas Pabst
Adrian F. Ochsenbein
Research29 Jun 2020
Nature Medicine

Volume: 26, P: 1459-1467
Analysis of autophagy in DLBCL reveals subtype-specific differences and the preferential targeting of ULK1 inhibition in GCB-DLBCL provides a rationale as a new therapeutic approach

Harpreet K. Mandhair
Ramin Radpour
Urban Novak
ResearchOpen Access23 Jan 2024
Leukemia

Volume: 38, P: 424-429
Delivery of Rapamycin Using In Situ Forming Implants Promotes Immunoregulation and Vascularized Composite Allograft Survival

Damian Sutter
Dzhuliya V. Dzhonova
Jonas T. Schnider
ResearchOpen Access25 Jun 2019
Scientific Reports

Volume: 9, P: 1-16

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Deep learning-enabled assessment of cardiac allograft rejection from endomyocardial biopsies

TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis

Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents

Analysis of autophagy in DLBCL reveals subtype-specific differences and the preferential targeting of ULK1 inhibition in GCB-DLBCL provides a rationale as a new therapeutic approach

Delivery of Rapamycin Using In Situ Forming Implants Promotes Immunoregulation and Vascularized Composite Allograft Survival

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