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Impact of diet and host genetics on the murine intestinal mycobiome

In this study, 591 mice from an advanced-intercross mouse line were used to provide evidence that fungi are regulated by host genetics, while uncovering a regulatory role of diet on the composition of fungi in the murine gut.

Yask Gupta
Anna Lara Ernst
Tanya Sezin
ResearchOpen Access14 Feb 2023
Nature Communications

Volume: 14, P: 1-17
Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome

Here, the authors have performed a multi-population GWAS meta-analysis of pediatric steroid sensitive nephrotic syndrome cases to discover 12 loci (4 novel), fine-map HLA, implicate kidney and immune factors, and associate the polygenic risk score with earlier disease onset.

Alexandra Barry
Michelle T. McNulty
Matthew G. Sampson
ResearchOpen Access29 Apr 2023
Nature Communications

Volume: 14, P: 1-13
Lifespan effects of mitochondrial mutations

Misa Hirose
Paul Schilf
Saleh M. Ibrahim
Research14 Dec 2016
Nature

Volume: 540, P: E13-E14
Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions associated with spontaneous autoimmunity development in these animals.

Artem Vorobyev
Yask Gupta
Ralf J. Ludwig
ResearchOpen Access10 Sept 2019
Nature Communications

Volume: 10, P: 1-15
Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

African Americans have an elevated risk of developing chronic kidney disease, yet only a fraction of those with high-risk genotypes develop the disease. Here, the authors show that a missense variant in APOL1 has a strong protective effect when co-inherited with the high-risk G2 allele of APOL1, with important implications for clinical practice and translational research.

Yask Gupta
David J. Friedman
Simone Sanna-Cherchi
ResearchOpen Access30 Nov 2023
Nature Communications

Volume: 14, P: 1-8
Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Misa Hirose
Paul Schilf
Saleh M. Ibrahim
ResearchOpen Access12 Apr 2018
Scientific Reports

Volume: 8, P: 1-15

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Impact of diet and host genetics on the murine intestinal mycobiome

Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome

Lifespan effects of mitochondrial mutations

Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

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Impact of diet and host genetics on the murine intestinal mycobiome

Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome

Lifespan effects of mitochondrial mutations

Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

Search

Quick links