LncRNA ROR knockdown inhibits cardiomyocyte pyroptosis and inflammation induced by ischemia/reperfusion (I/R), while miR-185-5p knockdown accelerates the effect. ROR promotes CDK6 expression by targeting miR-185-5p. ROR promotes cardiomyocyte damage and pyroptosis by increasing CDK6 expression via miR-185-5p, suggesting that ROR may be a new therapeutic target of myocardial I/R injury.
- Jing Sun
- Yan-Meng Zhu
- Ying-Ping Liang
