Nature Search

Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma

The molecular characterisation of soft tissue sarcomas (STSs) across diverse populations remains crucial. Here, the authors perform a proteomics and phosphoproteomics analysis of 272 Chinese STS patients across 12 subtypes, and obtain insights related to progression, metastasis, and immune signatures.

Shaoshuai Tang
Yunzhi Wang
Chen Ding
ResearchOpen Access15 Feb 2024
Nature Communications

Volume: 15, P: 1-24
Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma

Non-small cell lung cancer manifests as adenocarcinoma and squamous cell carcinoma but tumours of mixed lineage are often found in humans. Here, the authors show that adenocarcinoma can transdifferentiate into squamous cell carcinomas in mice.

Xiangkun Han
Fuming Li
Hongbin Ji
ResearchOpen Access17 Feb 2014
Nature Communications

Volume: 5, P: 1-13
Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ

Urothelial bladder cancer (UC) progression occurs as a multi-step process that leads to different kinds of lesions and subtypes. Here, the authors characterise benign and invasive lesions that occur during UC progression using proteogenomics in patient samples and show critical molecular pathways and prognostic associations.

Zhenmei Yao
Ning Xu
Chen Ding
ResearchOpen Access13 Sept 2023
Nature Communications

Volume: 14, P: 1-25
Erratum: YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression

Yijun Gao
Wenjing Zhang
Hongbin Ji
Amendments and Corrections27 Feb 2015
Nature Communications

Volume: 6, P: 1-2
Integrative proteogenomic characterization of early esophageal cancer

The progression of oesophageal squamous cell carcinoma (ESCC) from early to advanced stages requires comprehensive molecular characterisation. Here, the authors perform a proteogenomics analysis of ESCC patient samples across nine histopathological stages and three phases, identifying key alterations and paths for progression.

Lingling Li
Dongxian Jiang
Chen Ding
ResearchOpen Access25 Mar 2023
Nature Communications

Volume: 14, P: 1-28
Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes

Duodenal cancer (DC) has complex subtypes and undergoes complicated morphological changes throughout progression, so understanding the molecular basis is crucial. Here, the authors perform a proteogenomics analysis of 156 DCs, revealing molecular subtypes as well as the roles of smoking, AARS1 and PARP1.

Lingling Li
Dongxian Jiang
Chen Ding
ResearchOpen Access29 Mar 2023
Nature Communications

Volume: 14, P: 1-24
Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals potential therapeutic strategies

The mechanisms of resistance to therapy in gastric cancer remain to be explored. Here, proteomic profiling of 206 tumour tissues from patients treated with chemotherapy and anti-HER2-based therapy results in the identification of four molecular subtypes and the development of prognostic models.

Yan Li
Chen Xu
Chen Ding
ResearchOpen Access29 Sept 2022
Nature Communications

Volume: 13, P: 1-26
Author Correction: Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma

Xiangkun Han
Fuming Li
Hongbin Ji
Amendments and CorrectionsOpen Access19 Jan 2022
Nature Communications

Volume: 13, P: 1-2
Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms

The proteogenomic landscape of diffuse gliomas remains to be explored. Here, the authors perform proteogenomic characterisation of diffuse gliomas, investigate the functional role of genomic alterations and suggest three proteomic subgroups.

Yunzhi Wang
Rongkui Luo
Chen Ding
ResearchOpen Access31 Jan 2023
Nature Communications

Volume: 14, P: 1-32
Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

Squamous cell carcinomas are an aggressive cancer type which can occur in multiple organ systems. Here, the authors analyse the proteome of SCC cancers from 17 organs and show commonly dysregulated proteins independent of ___location.

Qi Song
Ye Yang
Yingyong Hou
ResearchOpen Access18 Jul 2022
Nature Communications

Volume: 13, P: 1-20
Author Correction: Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals potential therapeutic strategies

Yan Li
Chen Xu
Chen Ding
Amendments and CorrectionsOpen Access08 Nov 2022
Nature Communications

Volume: 13, P: 1
Role of surgery in patients with focally progressive gastrointestinal stromal tumors resistant to imatinib

Xiaodong Gao
Anwei Xue
Xinyu Qin
ResearchOpen Access07 Mar 2016
Scientific Reports

Volume: 6, P: 1-6
Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma

The m6A reader IGF2BP3 is upregulated in various cancer, including glioblastoma. Here the authors report that IGF2BP3 facilitates NETosis and glioma survival as well as resistance to oncolytic herpes simplex virotherapy.

Weiwei Dai
Ruotong Tian
Minfeng Shu
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-19
USP38 functions as an oncoprotein by downregulating the p53 pathway through deubiquitination and stabilization of MDM2

Shanyu Zhao
Xiaoli Liu
Pingzhao Zhang
Research22 Feb 2025
Cell Death & Differentiation

Volume: 32, P: 1128-1141
PIK3C2A is a gene-specific target of microRNA-518a-5p in imatinib mesylate-resistant gastrointestinal stromal tumor

Yuan Shi
Xiaodong Gao
Yingyong Hou
Research07 Mar 2016
Laboratory Investigation

Volume: 96, P: 652-660
Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses

Acral melanoma (AM) is a rare melanoma subtype with unique features, where lymph node metastasis is closely associated with clinical outcomes. Here, the authors use single-cell and spatial transcriptomics to analyse early dissemination, tumour microenvironment, and heterogeneity in AM, and infer metabolic shifts with therapeutic implications.

Chuanyuan Wei
Wei Sun
Jianying Gu
ResearchOpen Access08 Dec 2023
Nature Communications

Volume: 14, P: 1-20
Integrated proteogenomic characterization of ampullary adenocarcinoma

Qiao Zhang
Xiaomeng Xu
Chen Ding
ResearchOpen Access07 Jan 2025
Cell Discovery

Volume: 11, P: 1-25
YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression

Lung adenocarcinomas can convert to squamous cell carcinomas, which is associated with cancer progression and therapy resistance. Here, Gao et al. identify YAP as an essential barrier for this phenotypic conversion through ZEB2-mediated DNP63 repression.

Yijun Gao
Wenjing Zhang
Hongbin Ji
Research13 Aug 2014
Nature Communications

Volume: 5, P: 1-15
Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

In breast cancer, the loss of expression of WW ___domain-containing oxireductase (Wwox) has been observed. Here, the authors illustrate that in triple negative breast cancer models Wwox suppresses metastasis and proliferation via the JAK2/STAT3 pathway.

Renxu Chang
Lele Song
Lixing Zhan
ResearchOpen Access28 Aug 2018
Nature Communications

Volume: 9, P: 1-12
PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

In colorectal cancer, EGFR signalling is implicated in metastasis. Here, the authors unravel a mechanism through which EGF stimulation induces MIIP phosphorylation, leading to MIIP interacting with RelA—this prevents RelA deactylation and enhances transcriptional activity, facilitating metastasis.

Tao Chen
Jingjie Li
Yuhui Jiang
ResearchOpen Access16 Oct 2017
Nature Communications

Volume: 8, P: 1-11
Proteogenomic insights into the biology and treatment of pan-melanoma

Hang Xiang
Rongkui Luo
Chen Ding
ResearchOpen Access23 Jul 2024
Cell Discovery

Volume: 10, P: 1-35
Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3

Yu Tao
Zhanjie Liu
Xiaoren Zhang
Research04 Jul 2018
Oncogene

Volume: 37, P: 5887-5900
Midostaurin potentiates rituximab antitumor activity in Burkitt’s lymphoma by inducing apoptosis

Xiaowen Ge
Jianfeng Chen
Weiguo Hu
ResearchOpen Access18 Dec 2018
Cell Death & Disease

Volume: 10, P: 1-12
An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk, local immunosuppression and tumor progression

Liang Wu
Jiayan Yan
Jian Zhou
ResearchOpen Access19 Jun 2023
Cell Research

Volume: 33, P: 585-603
Characteristic sequence motifs located at the genomic breakpoints of the translocation t(X;18) in synovial sarcomas

Yongkun Wei
Menghong Sun
Xiongzeng Zhu
Research10 Apr 2003
Oncogene

Volume: 22, P: 2215-2222
Establishment and characterization of esophageal squamous cell carcinoma patient-derived xenograft mouse models for preclinical drug discovery

Jingchuan Zhang
Dongxian Jiang
Qun Wang
Research07 Jul 2014
Laboratory Investigation

Volume: 94, P: 917-926
HLA-A⁺ tertiary lymphoid structures with reactivated tumor infiltrating lymphocytes are associated with a positive immunotherapy response in esophageal squamous cell carcinoma

Dandan Zhang
Dongxian Jiang
Zhihua Liu
Research18 May 2024
British Journal of Cancer

Volume: 131, P: 184-195
Deep learning on tertiary lymphoid structures in hematoxylin-eosin predicts cancer prognosis and immunotherapy response

Ziqiang Chen
Xiaobing Wang
Yun Liu
ResearchOpen Access22 Mar 2024
npj Precision Oncology

Volume: 8, P: 1-11
Ca_v2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization

Ying Xue
Min Li
Qihong Huang
ResearchOpen Access22 Sept 2022
Cell Death & Disease

Volume: 13, P: 1-12
Utility of cell-free DNA from bronchial washing fluid in diagnosis and genomic determination for radiology-suspected pulmonary nodules

Xinyu Zhang
Zhuo Yu
Xin Zhang
Research17 Oct 2022
British Journal of Cancer

Volume: 127, P: 2154-2165
Tumour infiltrating lymphocytes correlate with improved survival in patients with esophageal squamous cell carcinoma

Dongxian Jiang
Yalan Liu
Chen Xu
ResearchOpen Access21 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis

Xi Chen
Xinwei Cao
Xiaoren Zhang
ResearchOpen Access01 Dec 2016
Cell Death & Disease

Volume: 7, P: e2508

Search

Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma

Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma

Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ

Erratum: YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression

Integrative proteogenomic characterization of early esophageal cancer

Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes

Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals potential therapeutic strategies

Author Correction: Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma

Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms

Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

Author Correction: Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals potential therapeutic strategies

Role of surgery in patients with focally progressive gastrointestinal stromal tumors resistant to imatinib

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma

USP38 functions as an oncoprotein by downregulating the p53 pathway through deubiquitination and stabilization of MDM2

PIK3C2A is a gene-specific target of microRNA-518a-5p in imatinib mesylate-resistant gastrointestinal stromal tumor

Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses

Integrated proteogenomic characterization of ampullary adenocarcinoma

YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

Proteogenomic insights into the biology and treatment of pan-melanoma

Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3

Midostaurin potentiates rituximab antitumor activity in Burkitt’s lymphoma by inducing apoptosis

An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk, local immunosuppression and tumor progression

Characteristic sequence motifs located at the genomic breakpoints of the translocation t(X;18) in synovial sarcomas

Establishment and characterization of esophageal squamous cell carcinoma patient-derived xenograft mouse models for preclinical drug discovery

HLA-A⁺ tertiary lymphoid structures with reactivated tumor infiltrating lymphocytes are associated with a positive immunotherapy response in esophageal squamous cell carcinoma

Deep learning on tertiary lymphoid structures in hematoxylin-eosin predicts cancer prognosis and immunotherapy response

Ca_v2.2-NFAT2-USP43 axis promotes invadopodia formation and breast cancer metastasis through cortactin stabilization

Utility of cell-free DNA from bronchial washing fluid in diagnosis and genomic determination for radiology-suspected pulmonary nodules

Tumour infiltrating lymphocytes correlate with improved survival in patients with esophageal squamous cell carcinoma

Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis

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