Nature Search

Disrupting bile acid metabolism by suppressing Fxr causes hepatocellular carcinoma induced by YAP activation

The crosstalk between bile acid (BA) metabolism and the Hippo pathway plays a role in pathogenesis of liver diseases. Here the authors show that the transcriptional coactivator YAP exerts a repressor role on Farnesoid X receptor (Fxr), the master transcriptional regulator of BA synthesis, contributing to the development of hepatocellular carcinoma.

Yuchen Liu
Juanjuan Zhu
Yingzi Yang
ResearchOpen Access15 Apr 2025
Nature Communications

Volume: 16, P: 1-19
Effectiveness of a booster dose of aerosolized or intramuscular adenovirus type 5 vectored COVID-19 vaccine in adults: a multicenter, partially randomized, platform trial in China

In this partially randomized clinical trial, the authors find that an orally inhaled Ad5-nCoV booster is associated with a lower incidence of symptomatic COVID-19 during the following 6 months compared with controls who haven’t received a booster. Intramuscular administered Ad5-CoV booster is associated with reduced COVID-19 incidence as well.

Siyue Jia
Yuanbao Liu
Jingxin Li
ResearchOpen Access26 Mar 2025
Nature Communications

Volume: 16, P: 1-12
Cullin-associated and neddylation-dissociated protein 1 (CAND1) promotes cardiomyocyte proliferation and heart regeneration by enhancing the ubiquitinated degradation of Mps one binder kinase activator 1b (Mob1b)

Xingda Li
Lingmin Zhang
Zhenwei Pan
Research24 Jun 2025
Cell Death & Differentiation

P: 1-15
Di (2-ethylhexyl) Phthalate decrease pregnancy rate via disrupting the microbe-gut-hypothalamic-pituitary-ovarian axis in mice

Linjie Xu
Jun Yan
Hongjuan Ding
ResearchOpen Access13 Jun 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-14
Erratum: High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

David M Valenzuela
Andrew J Murphy
George D Yancopoulos
Amendments and Corrections01 Jul 2003
Nature Biotechnology

Volume: 21, P: 822
LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

The Hippo and mTORC1 pathways regulate growth control for proper organ development. Here, Gan et al. find that the Hippo pathway kinases LATS1 and LATS2 phosphorylate the mTORC1 component Raptor to attenuate mTORC1 activation.

Wenjian Gan
Xiaoming Dai
Wenyi Wei
Research03 Feb 2020
Nature Cell Biology

Volume: 22, P: 246-256
Cbfβ interacts with Runx2 and has a critical role in bone development

Mondira Kundu
Amjad Javed
P. Paul Liu
Research18 Nov 2002
Nature Genetics

Volume: 32, P: 639-644
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

Intestinal IL-22 has important regulatory effects on the barrier and intestinal diseases and its production is controlled by the intestinal microbiome. Here the authors show that intestinal immune cell production of IL-22 is regulated by short chain fatty acids via an aryl hydrocarbon receptor and HIF1α-mediated mechanism that protects mice from intestinal inflammation.

Wenjing Yang
Tianming Yu
Yingzi Cong
ResearchOpen Access08 Sept 2020
Nature Communications

Volume: 11, P: 1-18
Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1

The crystal structure of Drosophila melanogaster YL1 in complex with an H2A.Z–H2B dimer exposes a selective recognition mechanism distinct from those of other H2A.Z chaperones and suggests a hierarchical transfer mechanism mediating H2A.Z deposition.

Xiaoping Liang
Shan Shan
Zheng Zhou
Research14 Mar 2016
Nature Structural & Molecular Biology

Volume: 23, P: 317-323
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

David M Valenzuela
Andrew J Murphy
George D Yancopoulos
Research05 May 2003
Nature Biotechnology

Volume: 21, P: 652-659
Specificity profiling of CRISPR system reveals greatly enhanced off-target gene editing

Yao Wang
Mingrui Wang
Quan Du
ResearchOpen Access10 Feb 2020
Scientific Reports

Volume: 10, P: 1-8
Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update

Cancer stem cells (CSCs) are implicated in cancer development, progression and resistance to treatment; therefore, the signalling pathways that mediate the CSC phenotype are attractive therapeutic targets. In this Review, the authors provide an update on the progress in targeting the Notch, WNT, Hedgehog and Hippo signalling pathways. Additionally, they discuss the interactions of CSCs with the immune system, the roles of CSC-related signalling pathways in immune cells and novel approaches to CSC-directed immunotherapy.

Joseph A. Clara
Cecilia Monge
Naoko Takebe
Reviews02 Dec 2019
Nature Reviews Clinical Oncology

Volume: 17, P: 204-232
Comprehensive transcriptome data for endemic Schizothoracinae fish in the Tibetan Plateau

Chaowei Zhou
Shijun Xiao
Haiping Liu
ResearchOpen Access21 Jan 2020
Scientific Data

Volume: 7, P: 1-7
Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation

Bo Peng
Yingzi Ming
Cheng Yang
ReviewsOpen Access25 Jan 2018
Cell Death & Disease

Volume: 9, P: 1-13
Cdc2-like kinases: structure, biological function and therapeutic targets for diseases

Mengqiu Song
Luping Pang
Zigang Dong
ReviewsOpen Access07 Apr 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-25

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