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Engineered pyroptotic vesicles formed during tumour cell pyroptosis and engineered as personalized tumour vaccines can activate a robust antitumour immune response for post-surgical tumour recurrence inhibition.

The authors strengthen the elasticity of Ag₂Se by microstructure engineering approach, realizing bendability of the thermoelectric generator for at least 1,000,000 times at a tiny bending radius of 3 mm with a high power density.

Existing isokinetic training devices are often heavy, bulky, and energy-consuming, which limits the rehabilitation opportunities only at designated hospitals. Here, the authors show a highly integrated and power-free knee rehabilitation robot that can provide home-based isokinetic training

Zhang, Mille-Fragoso and colleagues developed a synthetic receptor platform named LIDAR (Ligand-Induced Dimerization-Activating RNA editing), which enables ligand-responsive gene regulation without the need of DNA promoters and is, thus, compatible with mRNA delivery.

Understanding the reprogramming of gene expression and metabolism is critical for the success of somatic embryogenesis-based plant tissue regeneration. Here, the authors report single-cell RNA-sequencing, spatial transcriptomics and spatial metabolomics analyses during cotton somatic embryo development.

DeepCAD-RT denoises fluorescence time-lapse images in real time.

Here, the authors show that a single mutation in JN.1 spike, L455S, confers better spike cleavage and enhances virus infectivity in differentiated primary human nasal epithelial cells while increasing immune evasiveness, contributing to the efficient spread of JN.1.

Skull-base chordoma (SBC) is a rare, aggressive bone cancer, but its molecular features remain to be characterised. Here, the authors perform proteogenomic analysis of 187 SBC tumours and identify chromosomal instability as a potential prognostic factor and potential therapeutic targets.

Evidence for comprehensive assessment of cardiovascular disease (CVD) burden attributable to high fasting plasma glucose (FPG) in China is limited. Here, the authors show CVD deaths attributable to high FPG varied substantially across China. Exposure to high FPG and population aging were the primary drivers of increased CVD burden.

A study details the molecular architecture of the double-membrane-spanning pore formed by the proteins nsp3 and nsp4 in double-membrane vesicles of SARS-CoV-2.

Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with long COVID.

Realizing an efficient turnover frequency by modifying the reaction configuration is crucial in designing single-atom catalysts. Here, authors report a “single atom–double site” concept, which involves activating inert atom redox chemistry.

The author report a Ru NPs/GaN NWs nanoarchitecture on Si for utilizing full spectrum to drive efficient and robust photothermal H₂ production from NH₃ with a high turnover number of >3,400,750 over 400 h.

Zhong et al. show that the protein GP73 stimulates hepatic glucose production and is induced in response to infection with SARS-CoV-2 in vitro and in vivo, thus proposing a molecular mechanism underlying hyperglycemia associated with COVID-19.

The replication and pathogenicity of the Omicron variant of SARS-CoV-2 is attenuated compared with the original strain and other variants.

Wireless delivery of both light and pharmacological agents is important for optogenetic and other mechanistic experiments in the brain. Here the authors present a wireless real-time programmable optofluidic platform that enables optogenetics and photopharmacology experiments that require real-time precise control of light and drug delivery.

Dongxin Lin and colleagues report a genome-wide association study for esophageal squamous cell carcinoma (ESCC) in Chinese populations, identifying nine new susceptibility loci. They also perform a genome-wide gene-environment interaction analysis with alcohol consumption, a known risk factor for ESCC.

Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.

Activation of ESCRT-mediated cell membrane repair can reduce the extent of tumor cell pyroptosis. Here the authors develop two formulations (an injectable hydrogel and a cell patch) for the sustained release of a Gasdermin-D bacteria-based delivery system and of biodegradable nanoparticles loaded with an ESCRT inhibitor, triggering pyroptosis and antitumor immune responses in preclinical cancer models.

Manipulating the redox chemistry of transition metal dichalcogenides still faces challenges. Here the authors report that tensile-strained MoSe2 can pass on the strain to its sodiated product Mo, and thus regulate the Gibbs free energy in the charging process to enable the reversible sodium storage.

Increased density of tumor associated macrophages has been correlated with tumor recurrence following surgery. Here the authors design an alginate-based hydrogel encapsulating anti-PD-1-conjugated platelets and nanoparticles loaded with the macrophage-depleting CSF-1R inhibitor pexidartinib, showing inhibition of post-surgery tumor recurrence in preclinical models.

Thermoelectric materials for low-grade heat recovery applications are limited to Bi₂Te₃-based alloys containing expensive Te for decades. Here, the authors demonstrate on a module level, cheap antimonides could enable an efficiency not inferior to that of expensive tellurides.

Social impairment and anhedonia are common negative symptoms in patients with schizophrenia. Here, the authors show that the histamine H₁ receptor in cholinergic neurons in the basal forebrain has a critical role in sensorimotor gating, social behaviour, and anhedonia-like behaviour in mice.

A global high-resolution disaster footprint analytical model is developed to show substantial socioeconomic impacts from climatic change-driven heat stress through the global supply chain by 2060 due to direct and indirect effects on health and labour productivity.

Breast cancer is frequently diagnosed using ultrasound. Here, the authors show that, in addition to ultrasound, shear wave elastography can be used to diagnose breast cancer and, in conjunction with deep learning and radiomics, can predict whether the disease has spread to axillary lymph nodes.

PD-L1 is highly expressed in triple-negative breast cancers (TNBC). Here, the authors show that nucleophosmin 1 (NPM1) transcriptionally activates PD-L1 expression and inhibits T cell activity in TNBC.

Rational regulation of electrochemical reconfiguration and exploration of activity origin are important for electrocatalysis. Here, a novel CoC₂O₄@MXene tubular catalyst is rationally designed to achieve rapid complete reconfiguration engineering during the hydrogen evolution reaction process.

Coronaviruses exploit the host caspase-6 to cleave coronavirus nucleocapsid protein into fragments with interferon-antagonizing activity to facilitate virus replication.

Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and an HLA class II locus of significance in high-risk populations. They reanalyze the strength of evidence for previously published risk loci.

Dongxin Lin and colleagues report a genome-wide association study for esophageal squamous-cell carcinoma in Chinese populations. They identify three new susceptibility loci at 5q11, 6p21 and 21q22.

Dongxin Lin and colleagues report a genome-wide association study identifying common variants in SLC39A6 associated with length of survival in individuals with esophageal squamous-cell carcinoma (ESCC). Higher expression of SLC39A6 in esophageal tissues was correlated reduced survival time in individuals with ESCC.