Nature Search

Publisher Correction: TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo

Jinhee Kim
Deepanwita Bose
Elena Martinelli
Amendments and CorrectionsOpen Access10 Oct 2024
Nature Communications

Volume: 15, P: 1
Automating cancer diagnosis using advanced deep learning techniques for multi-cancer image classification

Yogesh Kumar
Supriya Shrivastav
Muhammad Fazal Ijaz
ResearchOpen Access23 Oct 2024
Scientific Reports

Volume: 14, P: 1-25
Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells

Anti-cancer treatment often results in a subset of the clonal cell population developing resistance to therapy, with resistant cells displaying a diversity of fate types resulting from the intrinsic variability among the clonal population before treatment.

Yogesh Goyal
Gianna T. Busch
Arjun Raj
Research19 Jul 2023
Nature

Volume: 620, P: 651-659
Ion-specific phenomena limit energy recovery in forward-biased bipolar membranes

Forward-biased bipolar membranes (FB-BPMs), which recover potential from pH gradients through ion–ion recombination, show promise for application in sustainable devices. The authors use physics-based modeling to elucidate how ion-specific phenomena dictate performance, reveal how selective ion management can mitigate energy losses and provide insights into the rational design of next-generation FB-BPMs.

Justin C. Bui
Eric W. Lees
Adam Z. Weber
Research20 Dec 2024
Nature Chemical Engineering

Volume: 2, P: 63-76
Unraveling non-genetic heterogeneity in cancer with dynamical models and computational tools

Identifying the origins and nature of non-genetic heterogeneity in cancer has widespread clinical ramifications. In this Review, the authors discuss how computational models and tools have been used to provide insights into this phenomenon and how they can help tackle the disease in the future.

Maalavika Pillai
Emilia Hojel
Yogesh Goyal
Reviews24 Apr 2023
Nature Computational Science

Volume: 3, P: 301-313
TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo

Treatment with the clinical stage TGF-β inhibitor galunisertib promotes latency reversal of HIV/SIV. Here, using a treatment regimen similar to the one tested in clinical trials, the authors show how galunisertib affects immune cell function, increases SIV reactivation, and reduces the viral reservoir in macaques.

Jinhee Kim
Deepanwita Bose
Elena Martinelli
ResearchOpen Access14 Feb 2024
Nature Communications

Volume: 15, P: 1-17
ClampFISH 2.0 enables rapid, scalable amplified RNA detection in situ

ClampFISH 2.0 enables highly specific multiplexed signal amplification in RNA FISH. The approach was used to detect 10 RNA species that ranged in abundance in more than 1 million cells and is also applicable to tissue sections.

Ian Dardani
Benjamin L. Emert
Arjun Raj
Research24 Oct 2022
Nature Methods

Volume: 19, P: 1403-1410
Divergent effects of intrinsically active MEK variants on developmental Ras signaling

Stanislav Shvartsman and colleagues quantify signaling changes caused by disease-associated mutations in MAP2K1 (encoding MEK) in fruit fly and zebrafish embryos. They find that intrinsically active MEK variants can both increase and reduce the levels of pathway activation depending on cellular context.

Yogesh Goyal
Granton A Jindal
Stanislav Y Shvartsman
Research06 Feb 2017
Nature Genetics

Volume: 49, P: 465-469
Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists

Developing biotechnologies to address society’s challenges requires integrating concepts across disciplines, posing challenges to educating students with diverse expertise. In this Perspective the authors create a framework for synthetic biology training that deconstructs biotechnologies across spatial scales.

Ashty S. Karim
Dylan M. Brown
Julius B. Lucks
ReviewsOpen Access26 Jun 2024
Nature Communications

Volume: 15, P: 1-14
ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma

Kasturee Jagirdar
Marie E. Portuallo
Vito W. Rebecca
ResearchOpen Access08 Dec 2023
Oncogene

Volume: 43, P: 395-405

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