In this study, IL-37d has been evidenced to bind lysosomal Rheb and suppress its activation in mTORC1 independent of TSC2. In hepatocyte, IL-37d is responsively decreased by ethanol and the recombinant TAT-rh-IL-37d protein improves alcohol-induced liver disorders via Rheb-mTORC1 axis.
- Nuo Chen
- Xiaoyu Wang
- Yan Li