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A nanobody was identified that targets the N-terminal fragment of the adhesion G-protein-coupled receptor ADGRG2, allosterically enhances activation by the natural agonist dehydroepiandrosterone and restores signaling in mutant receptors.

Authors use a high-entropy engineering approach to produce fully amorphous BiTO films by exfoliation and annealing, creating crystalline regions, leading to flexible ceramics with dielectric properties.

Substituted 1,3,4-thiadiazoles find extensive use in pharmaceutical, agricultural, and materials chemistry. Herein, the authors report the synthesis of multi-functionalized 1,3,4- thiadiazoles via sulfur-mediated direct coupling between primary nitroalkanes and acyl hydrazines.

A versatile nano-adaptor is used to construct multi-specific nano-antibodies for treatment of tumours in mice.

TSTO is a trioxane-based MS-cleavable cross-linker that enables the capture and identification of trimeric protein interactions of cellular networks. The enhanced spatial resolution facilitates characterization and modeling of protein complexes.

BMP signaling forms an intestinal gradient regulating villus length by balancing cell proliferation with apoptosis to optimize nutrient absorption efficiency across regions.

Nanocatalysts with multifaceted catalytic properties are promising for therapeutic uses but remain underexplored. Here, the authors report two-dimensional BiCuSeO nanosheets that exhibit multimodal energy transformation-mediated sono-piezoelectric, photothermoelectric and enzyme-mimicking activities, allowing tumour eradication and bacterial infection treatment with spatiotemporal controllability.

A large range of inert and non-defective sites in catalysts is a primary factor impeding catalyst activity in acidic CO₂ electroreduction. Here, the authors achieve high HCOOH selectivity and activity in acidic electrolyte by introducing tensile strain to activate inert sites.

Here, the authors develop an antiferromagnet/topological insulator heterostructure, MnSe/(Bi,Sb)₂Te₃, to obtain laser-induced transient magnetic moment and optically controllable circularly polarized ultrafast terahertz pulse generation, under zero external magnetic field.

A general two-step intercalation and cation-exchange strategy is used to produce a library of highly ordered magnetic intercalation superlattices with tunable chemical modulations and magnetic ordering.

Electrochromic smart windows and rechargeable batteries need external power sources to operate. Here, Sun et al.present a bi-functional device consisting of Prussian blue and aluminium electrodes, which shows potential applications in both self-powered smart windows and self-rechargeable batteries.

The two-dimensional semiconductor Bi₂O₂Se can be oxidized to create an atomically thin layer of Bi₂SeO₅ that can be used as the insulator in scaled field-effect transistors.

Although several inorganic analogues of cyclopentadiene have been reported with group-15 elements, examples featuring the heavier elements Sb and Bi remain scarce. Now, a Bi₅ ring has been stabilized between two Nb(cyclopentadienyl) units, forming a triple-decker sandwich structure; the bonding analysis indicates that a Nb–Nb bond goes through the centre of the Bi₅ plane.

The coupling of ferroelectricity and magnetic order enables the tunability of material properties. Here, authors realize magnetic-field-enhanced ferroelectricity and electrical-field-controlled magneto-transport in non-magnetic moiré superlattices.

Helical Dirac fermion states that emerge at the surface of topological insulators support a variety of exotic physical phenomena, but they disappear when a topological insulator becomes too thin. Wang et al.show that these states are recovered when ultrathin films are interfaced together.

Melting and squeezing pure metals between two sapphires covered in molybdenum disulfide produces diverse two-dimensional metals at the ångström thickness limit.

An atomically thin high-κ gate dielectric of Bi₂SeO₅ can be formed via layer-by-layer oxidization of an underlying two-dimensional semiconductor, allowing high-performance field-effect transistors and inverters to be fabricated.

Electrified reactive capture converts CO₂ from carbonate solutions but suffers from low Faradaic efficiency. Here, the authors report a templated synthesis with defined pores and Ni single atoms to accumulate CO₂, achieving 46% energy efficiency to syngas at 300 mA/cm²

Oxide-ion conductors are important energy materials. Here, the authors found a tellurite-based oxygen ion conductor highlighting the interplay of secondary bond interactions and Grotthuss-like processes.

The development of vertical p-i-n junctions has been hindered by complex fabrication techniques and performance trade-off between responsivity and speed. Here, authors employ WSe₂ thin layers to construct photodiode, reporting responsivity of 0.388 A/W and response time down to sub-10 picoseconds.

Activating C–H bonds without using a directing group remains a continual goal of organic chemistry given the synthetic advantages of such an approach. Here, the authors demonstrate that iron(III) salts containing weakly coordinating anions could directly activate C(sp²)–H or C(sp³)–H bonds without the assistance of a directing group.

Bi₂O₂Se is a promising 2D semiconductor with high electron mobility and native high-k dielectric layers, but its p-type doping remains challenging. Here, the authors report a low-temperature substitutional doping method to fabricate 2D Bi₂O₂Se p-n junctions and p-type transistors

Fluorophores typically emit either in solution or in solid state due to several distinct effects. Here, the authors design a single-benzene fluorophore with efficient emission in both phases, enabling applications in photocatalysis and optical waveguiding.

2D semiconductors are attracting attention as a potential alternative for post-silicon electronics, but the fabrication of high-performance 2D p-type transistors remains a challenge. Here, the authors report the realization of bilayer WSe₂ p-type transistor arrays with on-state currents up to 421 μA/μm, on/off ratios exceeding 10⁷ and subthreshold swings as low as 75 mV/decade.

Iron dysregulation is a hallmark of many human diseases and cancers. In this study, the authors show that iron depletion, overload, or improper storage drive templated insertions at chromosome breaks, a class of events that are common yet poorly understood in cancer.

The utilization of Mg₃(Sb,Bi)₂ in thermoelectric devices is hindered by its low performance near room temperature. Here, authors report thermoelectric performance enhancement of Mg₃(Sb,Bi)₂ within a wide temperature range by incorporating metallic inclusions at grain boundaries. (279 in total)

Compartmentalization of phase-separated microdroplets is a key challenge in emulating native cells. Here, the authors report the assembly of compartmentalized, phase-separated cyanuric acid/polyadenine coacervate microdroplets, and the switchable light-stimulated and catalytic reconfiguration of their compartments.

It is of high interests to design catalysts for CO2 electroreduction with enhanced selectivity and activity. Here, the authors report Sn-Bi bimetallic interface-rich material with enhanced performance for CO2 reduction to formate comparing to that of Sn-Bi bulk alloy.

High-yield production of well-performing protein materials is challenging due to their high molecular weights and repetitive sequences. Here the authors develop a method to boost the strength of low molecular-weight protein materials by bi-terminal fusion of intrinsically-disordered mussel foot protein fragments, while achieving high yield.

While the conversion of CO₂ to high-value products provides a promising means to remove and utilize atmospheric carbon, few materials can do so without wasteful, sacrificial reagents. Here, authors prepare single-atom Co on Bi₃O₄Br nanosheets as CO₂ reduction catalysts using water and light.

Nerve fibers relaying pain information from peripheral organs are normally supported by specialized glial cells called nonmyelinating Schwann cells. Here, the authors show that a secreted factor, SEMA3B, promotes nerve fiber-Schwann cell interactions necessary for suppressing pathological pain.

Stem cell therapies face immune rejection risks with allogeneic ESCs. Here, the authors establish genetically matched autologous ESCs in monkeys via embryo splitting, showing potentially superior genomic stability over iPSCs and ntESCs.

Here the authors describe an acidic pH-responsive high-valence bismuth(V)-based nanoplatform that promotes exogenous excitation-free and endogenous H₂O₂- and O₂-independent ROS generation, eliciting cancer cell death and anti-tumor immune responses.

Efficient charge separation plays a crucial role in enhancing artificial photocatalysis. Here, the authors report an alkali etching method to construct an electron transfer layer on BiVO₄:Mo photocatalysts, leading to a charge separation efficiency exceeding 90% at 420 nm.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

A screening approach finds VH-___domain antibodies that bind the SARS-CoV-2 Spike protein receptor-binding ___domain at its interface with host ACE2. Bi-paratopic and multivalent binders have high affinity and potency.

Achieving high pure formic acid production from CO₂ electroconversion is of high interest yet challenging. Here the authors report vitamin C functionalized Bi₃S₂ nanowire catalyst to achieve selective, active, and stable formic acid production.

The application of spin-orbit torque in topological insulator heterostructures is limited only under low temperature. Here, the authors report room temperature magnetization switching in topological insulator-ferromagnet heterostructures by spin-orbit torques.

The epitaxial synthesis of high-density, vertically aligned arrays of two-dimensional (2D) fin-oxide heterostructures is described, enabling the fabrication of 2D fin field-effect transistors with high electron mobility and desirable low-power specifications.

Incorporating thiophene and furan isomers into covalent organic frameworks tunes their electronic structures, enhances charge separation, and stabilizes reaction intermediates, enabling high photocatalytic H₂O₂ yields in both ethanol and water.

Single-atom catalysts provide atomic-level control over active sites but often lack orbital-level manipulation. Here the authors demonstrate orbital engineering of a Cu catalyst, achieving control over coordination geometry and high metal loading.

Here, the authors report the ledge-guided epitaxial growth of high-density 2D Bi₂O₂Se fin arrays and their application for the realization of 2D multi-channel fin field-effect transistors, showing improved on-state currents as the number of integrated channels is increased.

Temperature difference induced H₂O₂ generation by thermoelectric materials is an attractive strategy for environmental remediation purposes. Here the authors demonstrate Bi₂Te₃ nanoplates based antibacterial filter as an effective candidate for indoor disinfection applications.

The authors achieve piezoelectric coefficient d₃₃ ∼ 807 pC·N⁻¹, along with high k₃₃ ∼ 88 % and T_c ∼ 245 °C in (K,Na)(Nb_1-xSb_x)O₃-Bi_0.5Na_0.5ZrO₃-BiFeO₃ system through structural flexibility and grain orientation strategies.

Here the authors identify genetic loci for asthma in East Asians using multi-trait GWAS. A CD36 missense variant shows protective effects and is validated through multi-omics, offering insights into asthma mechanisms and precision therapy.

By introducing Ni dopants into monolayer Bi₂WO₆, Bi/O frustrated Lewis pairs, unsaturated W atoms, and Ni active units are formed. The authors show that these units facilitate oxygen species transfer and enhance photocatalytic toluene oxidation.

Applying a magnetic field to the topological material Bi₈₈Sb₁₂ enhances the Seebeck coefficient, resulting in a high thermoelectric figure of merit zT of 1.7 at 180 K and 0.7 T.

The long-term stability of perovskite solar cells remains a critical challenge for the commercialization of the technology. Here, the authors adopt a non-noble metal/metal oxide/polymer multiple-barrier to suppress device degradation, achieving long-term stability in encapsulated p-i-n devices.

Xu et al. report reconfigurable phototransistors based on MAPbI₃/Bi₂O₂Se heterostructure, with momentum conservation promotes hot carrier extraction and interlayer carrier transport. Heterotransistor array enables traffic light signal detection under dim light, assisted by YOLOv4 neural network.