Asymmetric Sonogashira C(sp3)–C(sp) couplings provide complementary approaches to established C(sp3)–C(sp2/sp3) couplings for chiral C–C bond formation; however, relatively few reactions have been developed. Now, a versatile, enantioconvergent Sonogashira coupling via a radical intermediate has been developed. The approach uses a copper catalyst featuring a multidentate electron-rich cinchona alkaloid-derived ligand.
- Xiao-Yang Dong
- Yu-Feng Zhang
- Xin-Yuan Liu