The ISWI chromatin remodelers interact with extranucleosomal DNA to mediate nucleosome positioning. A new study now shows that the conserved SLIDE ___domain in the Isw2 subunit, which binds linker DNA, facilitates unidirectional linker DNA movement into nucleosomes. These findings suggest that the SLIDE ___domain functions in conjunction with the ATPase ___domain to mobilize nucleosomes.
- Swetansu K Hota
- Saurabh K Bhardwaj
- Blaine Bartholomew