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Reshaping of thiamine-dependent enzymes with ferrocene-mediated electrocatalysis can unlock an unnatural dynamic kinetic oxidation of α-branched aldehydes, providing new opportunities for making molecules.

Metal oxide semiconductor-based sensors are promising for hydrogen detection but their detection speed and selectivity are still limited. Here, a hydrogen sensor consisting of palladium single atom-doped tin oxide shows a response speed to hydrogen of 3 s and a detection limit of 50 parts per billion.

Using fNIRS hyperscanning and Granger Causality analysis, this study unveiled a hierarchical organization of bidirectional communication during cooperative learning with emergent leadership.

A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.

Catalytic asymmetric synthesis of optically pure 1,n-diols from bulk chemicals in a stereoselective and atom-economical manner remains a challenge. Here, the authors report a modular method for the synthesis of enantioenriched 1,2-diols and 1,3-diols from the high-production-volume chemicals ethylene glycol and 1,3-propanediol, respectively.

This study demonstrates a role of cholesterol metabolism-related gene, Lrp3, in cartilage degeneration and osteoarthritis pathogenesis. LRP3 positively regulates cartilage extracellular matrix metabolism by targeting syndecan-4 via Ras signalling, implicating the cholesterol-LRP3-SDC4 axis in osteoarthritic cartilage degeneration.

SF₆/N₂ separation is crucial for sustainable development. Here, the authors prepared low-cost and robust MOF composite pellets and established a vacuum temperature swing adsorption process with both high recovery and high purity of SF₆.

Eye tracking techniques enable high-efficient, natural, and effortless human-machine interaction. Here, Zhu et al. proposed a contact lens to track eye movement for wireless eye-machine interaction

A strong positive correlation between the warm and hot phases of extended filaments in massive galaxies within cooling-flow clusters supports theoretical models of active galactic nucleus feedback as the origin of these multiphase structures.

Invariant natural killer T (iNKT) cells are important contributors to anti-tumour immunity, but they often become dysfunctional in cancers. Here authors show that inhibited iNKT intra-tumour motility and iNKT cell exclusion from tumours by macrophages both contribute to their diminished function in cancer, and by therapeutic interference with the respective motility and iNKT-macrophage interaction pathways, their function can be restored.

The invasiveness of extensive craniotomy hinders large-scale cortex mapping. Here, the authors developed a flexible, shape-changing electrode array which enables minimally invasive implantation and achieves high spatiotemporal resolution brain mapping.

Reducing non-radiative energy loss is critical to improving power conversion efficiency in organic solar cells. Jiang et al. show that alkyl side-chain engineering in acceptors reduces the free volume ratio, lowering non-radiative decay, to achieve 18.6% efficiency in bulk-heterojunction binary cells.

CRISPR screen identifies coactivators of the androgen receptor (AR) complex, including NSD2. NSD2 contributes to AR cistrome reprogramming during prostate cancer progression, and its degradation via a novel PROTAC reduces prostate cancer cell viability in vitro.

Gold-nanoparticle-coated titania nanowire arrays subretinally implanted in blind mice and monkeys offer advantages in visual acuity and contrast sensitivity towards the restoration of visual function.

The assembly of the γδ TCR depends on Vγ usage.

The energy content of secondary batteries is often limited by the charge carriers available in the system. Here, the authors employed an anion acceptor cathode for simultaneous use of electrolyte anions and cations as effective charge carriers in solid polymer electrolytes for lithium-based batteries.

Mosquito-derived xanthurenic acid (XA) is a trigger for gametogenesis of Plasmodium parasites. Here the authors show that the putative amino acid transporter GEP1 is required for XA-stimulated gametogenesis in Plasmodium yoelii and that it interacts with guanylyl cyclase α (GCα), a cGMP synthesizing enzyme in gametocytes.

The molecular landscape of microphthalmia transcription factor family translocation renal cell carcinoma tumours remain to be characterised. Here, the authors perform proteogenomic analysis and reveal dysregulation of DNA repair, mTOR signalling and metabolic processes.

IL-17 mediated inflammation in the lung is mediated by different effector molecules. Here the authors show that the epigenetic regulator epithelial sirtuin 6 (Sirt6) is associated with lung inflammation in asthma patients and that Sirt6 contributes to promotion of inflammation in mouse asthma models.

Myeloid cell subsets are playing important roles in antitumour immunity, and genes affecting their functions are potential targets for immunotherapy. Here authors show that genomic deletion of Pikfyve in CD11c⁺ cells results in tumour growth inhibition via enhanced antigen presentation and priming of antigen-specific CD8⁺ T cells in a mouse tumor model.

PROTAC degrader–induced SWI/SNF inactivation abolishes DNA accessibility at enhancer elements of oncogenes and also tempers supra-physiologic expression of driver transcription factors, resulting in potent inhibition of tumour growth in mouse models.

In this study, the authors develop a comprehensive taxonomy of brain-wide SPNs, identifying several novel subsets via their transcriptional signatures.

The human AAA+protein p97 plays an important role in cellular protein homeostasis. Here, the authors use cryo-EM to obtain further insights into how p97 interacts with its co-factor Npl4 and they observe three distinct conformational states of Npl4 in complex with human p97, which suggests that a seesaw motion is essential for the unfolding activity of the p97 complex.

Combining standard 4-6 cycles of chemotherapy with immune checkpoints inhibitors has shown to improve survival in patients with non-small cell lung cancer (NSCLC), however increased toxicities have also been reported. Here the authors report the results of a phase 2 trial of sintilimab (anti-PD1) with two cycles of chemotherapy for treatment of previously untreated advanced squamous NSCLC.

Nanocomposite (NC) printing emerged as a major approach to translate nanomaterial properties to 3D geometries but printing of conventional NCs lacks control over nanomaterial connection. Here, the authors develop viscoelastic Pickering emulgels as NC inks through jamming nanomaterials on interfaces and in continuous phase

A subset of intestinal stromal cells that is regulated by the kinase MAP3K2 protects intestinal stem cells against injury by producing the WNT agonist R-spondin 1.

YEATS domains are histone acylation readers that recognize crotonyllysine and acetyllysine. Here the authors provide structural insights into how YEATS domains recognize acetyllysines and further show that the human AF9 YEATS ___domain also binds DNA.

The assembly of the genome of the koala provides insights into its adaptive biology and identifies gene expansions that contribute to its ability to detoxify eucalyptus-derived compounds and perceive plant secondary metabolites.

The role of PIWI proteins in mammalian reproduction remains poorly understood. Here, using golden hamsters, the authors establish expression profiles for all four PIWIs during gametogenesis and characterize their associated reproductive defects.

Chinnaiyan and colleagues perform a high-throughput compound screen and identify PIKfyve inhibition as a therapeutic strategy to enhance immune checkpoint blockade responses in advanced prostate cancer.

The authors present multifunctional nanoagents that can be used for imaging and treatment of bacterial infections. The nanoagents are made of fluorescent silicon nanoparticles functionalized with a glucose polymer and loaded with chlorin e6, and are taken up by bacteria via ABC transporters.

Structural and biophysical analysis of the histone acetyltransferase MOZ double PHD finger (DPF) ___domain reveal that DPF exhibits strong binding preference for crotonylated Lys14 in histone H3 (H3K14) and are co-localized in cells.

Chemerin plays a protective role in acute kidney injury by repressing ferroptosis in renal tubular cells, which is likely through activation of the AMPK/NRF2/SLC7A11 axis.

Carbon neutrality initiative has stimulated the development of the sustainable methodologies for hydrogen generation and safe storage. Here the authors demonstrate that the dual-active sites of Pt single-atoms and frustrated Lewis pairs on porous nanorods of CeO2 enable the efficient additive-free H2 generation with a low CO generation through reforming of methanol and water.

Psoriasis is accompanied by NF-κB activation and hyperplasia. Here the authors show that NF-κB transcriptionally activates miR-31, which downregulates a negative cell cycle regulator protein phosphatase 6, and that this is critical for NF-κB to drive keratinocyte hyperproliferation.