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The phytohormone abscisic acid (ABA) regulates a variety of physiological processes in plants. A molecule involved in chlorophyll biosynthesis, the H-subunit of Mg-chelatase functions as an ABA receptor. This interaction controls seed germination and stomatal movement.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Reconstructing and predicting spatiotemporal dynamics from sparse sensor data is challenging, especially with limited sensors. Li et al. address this by using self-supervised pretraining of a generative model, improving accuracy and generalization.

The removal of terminal sialic acid residues on glycans at the T-cell–tumour-cell interface via a sialidase fused to a bispecific T-cell engager enhances the susceptibility of solid cancers to T-cell-mediated cytolysis.

Hematopoietic stem cells are held in check to maintain their functional activity throughout life. Qian and colleagues show that the transcriptional regulator Foxm1 maintains the quiescence and self-renewal capacity of these cells in vivo.

Multiblock copolymers (MBCPs) comprising polyester and polyacrylate segments offer an efficient strategy for enhancing the performance of polyester and polyolefin blends but synthesis and structural modification of these MBCPs remains challenging. Here, the authors propose a method for synthesizing MBCPs via the switchable polymerization of epoxides, cyclic anhydrides, and acrylates using a dinuclear Co-complex.

Miyazaki et al. characterize vepafestinib, a next-generation RET inhibitor that is selective for wild-type RET and solvent front mutants. Due to a unique binding mode, it has enhanced brain penetrance and overcomes resistance to other RET inhibitors.

Phage Thoeris anti-defence proteins Tad1 and Tad2 both achieve anti-CBASS activity by simultaneously sequestering CBASS cyclic oligonucleotides.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Multiple synchronous lung cancers (MSLCs) are a subtype of lung cancer. Here the authors characterise MSLCs using single cell RNA sequencing, single cell TCR sequencing and bulk whole-exome sequencing to investigate the mutations that arise in and are associated with invasive adenocarcinoma development, and immune microenvironment changes in this process.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

CD36 is a membrane glycoprotein that has been shown to have tumour promoting or suppressor function depending on tumour type. Here, the authors address CD36 function in colorectal cancer and show it acts as a tumour suppressor by inhibiting B-catenin/myc signalling, resulting in downregulation of glycolysis.

The de novo design and synthesis of the Sc 2.0 chromosome XIII enable in-depth investigations into biology. Here the authors construct the 884 Kb synXIII of Saccharomyces cerevisiae to investigate replicative aging.

It is unclear whether somatic mutation rates are elevated in Lynch Syndrome (LS), which is the most common cause of hereditary colorectal cancer. Here, the authors use whole-genome sequencing and organoid cultures to show that normal tissues in LS patients are genomically stable, while ancestor cells of neoplastic tissues undergo multiple cycles of clonal evolution.

In Arabidopsis, mechanisms for NRG1A activation by recognition of a modified host EDS1–SAG101 complex, and NRG1A inhibition by NRG1C through sequestration of activated EDS1–SAG101, show activation and constraint of a central plant immune response system.

Margaret Goodell, Wei Li and colleagues report conditional ablation of the Dnmt3a DNA methyltransferase in hematopoietic stem cells (HSCs) in mice. They show that Dnmt3a is critical for epigenetic silencing of HSC regulatory genes and for HSC differentiation.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

There is a long-standing trade-off between high piezoelectricity and good temperature stability for piezoceramics. Here, authors combine phase boundary engineering and process engineering to relieve this relationship in (Pb, Zr) TiO3 piezoceramics.

Wood-based electronics are typically constrained in their ability to undergo complex shape deformation. Here, authors integrate transparent wood film and cellulose-based conductive ink for flexible electronic origami devices that have been demonstrated as a proof-of-concept for human motion sensors.

The development of seawater electrolysis for green hydrogen production is crucial to addressing energy shortages. Here, the authors report that integrating NiFe sulfides with MXene enhances oxygen evolution reaction efficiency and stability, achieving 1000 hours of durability in seawater electrolysis.

Applying economic complexity methods, this study maps global progress toward the SDGs, uncovering distinct development paths and disparities among 166 countries. It highlights overlooked areas in sustainable development, offering insights into how nations can better achieve the SDGs.

The authors find that highly ordered ferroelectric hybrid perovskite domains exhibit planar chirality that switches sign between adjacent domains, which manifest in a large dichroic ratio for circularly polarized second harmonic generation from the ___domain walls.

The authors realize high energy storage performance in polymer-based composites by integrating two-dimensional bismuth layer-structured Na_0.5Bi_4.5Ti₄O₁₅ ferroelectric micro-sheets and bilayer structure.

Derivation of human primordial germ cell-like cells (hPGCLCs) is critical for reproductive medicine. Here, authors report the induction of hPGCLCs in a bioengineered human pluripotent stem cell culture that mimics peri-implantation human development.

The design of new combinatorial regimens represents an opportunity to improve response to immune checkpoint inhibitors in patients with cancer. Here the authors computationally model the interaction between chemotherapy and immunotherapy by studying treatment-induced expression changes associated with response to anti-PD-1, identifying chemotherapeutic drugs or small molecule inhibitors that can overcome resistance to anti-PD-1.

China’s zero-COVID policy was discontinued in December 2022 and was followed by a wave of COVID-19 infections. Here, the authors demonstrate that the end of this policy also coincided with increased antibiotic use, indicating possible inappropriate prescribing.

The authors report an Initial Upper Palaeolithic archaeological assemblage from China dating to 45,000 years ago that includes blade technology, tanged and hafted projectile points, long-distance obsidian transfer and the use of a perforated graphite disc.

Wang, Zhang, Zheng et al. demonstrate that tumour cell-derived lymphotoxin-β activates NF-κB2 signalling and CCL2/5 secretion in osteoblasts to promote bone metastasis in breast cancer, which may potentially be targeted with a decoy receptor in vivo.

Robotic surgery has been demonstrated to improve short-term outcomes for patients with gastric cancer who received a gastrectomy, but the long-term effects are less clear. Here, the authors report the survival outcomes of their phase 2 randomized controlled trial comparing robotic to laparoscopic distal gastrectomy in patients with resectable gastric cancer.

By resonant pumping the organic cation in 2D perovskite, Fu et al. report the electronic and mechanical couplings between the organic and inorganic sublattices, evidenced by the reduced bandgap and modified lattice degree of freedom within the inorganic sublattice, and slow heat transfer process.

The synthesis of polymers with diverse properties is often limited by the lack of methods to produce the required monomers. Now, the regio- and diastereoselective synthesis of 5,6-diaryl cyclooctene monomers is reported using nickel catalysis. The monomers can be used in ring-opening metathesis polymerization reactions to form polymers with head-to-head styrene dyads.

For bioinspired structural materials, integral preparation of multiscale structures remains challenging. The authors report a hierarchical strategy to assemble multiple micro-nano units to complex multiscale structures integrally synchronously.