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Protonic ceramic electrochemical cells (PCECs) interconvert hydrogen and electricity and therefore have potential as long-duration energy storage systems, but the durability of these devices under industrially relevant conditions is limited. Here the authors report a PCEC that maintains low degradation rates throughout exceptionally long-term durability tests.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and electron microscopy, tissue clearing and time-lapse super-resolution microscopy.

Metallic bone scaffolds can’t be soft and strong. Here, the authors design a two-stage metamaterial scaffold with decoupled strength and modulus. By inducing greater tissue strain, it enhances osteogenesis and angiogenesis in ulnar defects model.

vdW assembly of low-dimensional materials has proven the capability of creating structures with on-demand properties. Here, the authors report on the structural collapse of CNTs in conjunction with a metal-semiconductor junction induced by the VdW encapsulation.

Predicting the effects of missense variants is important in discovering disease risk genes and clinical genetic diagnostics. Here the authors introduce a deep learning method (MisFit) to estimate the fitness effects of all possible human missense variants using large population data, achieving superior performance in prioritizing risk variants in early-onset conditions.

Succinylation, a posttranslational modification on lysine residues, is involved in tumor progression. Here, authors show that PDHA1 K83 succinylation is involved in cholangiocarcinoma tumorigenesis through regulation of macrophage antigen presentation in the tumor microenvironment

Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al.conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout.

The relevance of spliceosome core components in cancer is less understood. Here the authors show SmD2, a core component of the spliceosome machinery, is under acetylation-dependent regulation, which could be targeted to enhance sensitivity to PARP inhibitors in hepatocellular carcinoma.

A two-step, video-based deep learning model is developed to first screen for cardiac anomalies using noncontrast magnetic resonance imaging, followed by diagnosis of 11 types of cardiovascular disease using gadolinium enhancement-based imaging.

Free-standing nitrogen-doped amorphous monolayer carbon consisting of mixed five-, six- and seven-membered rings was prepared through the polymerization of pyrrole within the confined interlayer cavity of a removable layered-double-hydroxide template.

Obtaining a protein crystal structure can be hampered by molecular flexibility. Here, the authors use precipitant-immobilized molecularly imprinted polymers to produce high quality crystals, such as of the fragile X mental retardation protein N-terminal ___domain, allowing for a detailed structural and functional analysis.

SCUBA-D is a denoising diffusion probabilistic model that can perform a variety of protein backbone design tasks, including generation of backbones from random noise, from user-sketched designs, and backbones to scaffold predefined motifs that can bind small molecules or other proteins.

Here the authors discover that furanodienone (FDN), a small molecule derived from ginger, exhibits PXR agonist activity selective for the intestine and show that when FDN is administered orally in pharmacological doses ameliorates induced colitis in male mice.

The STING-relayed inflammation response has been increasingly identified as one of the key drivers of NAFLD progression. Here the authors show that an E3 ubiquitin ligase, RNF13, can ameliorate NAFLD phenotypes by facilitating the TRIM29-mediated degradation of STING.

Indica rice has higher nitrate assimilation and nitrogen use efficiency (NUE) than japonica rice, but the mechanism is unclear. Here, the authors reveal that the difference is partly due to allelic variation of a nitrate reductase encoding gene and this indica allele can increase yield potential and NUE.

Zika virus (ZIKV) has spread rapidly in recent years and there is a need for antiviral treatments. Here, the authors develop an antiviral peptide, based on the stem region of ZIKV envelope protein, and show that it is safe in pregnant mice and inhibits ZIKV infection in pregnant mice and fetuses.

The photovoltaic performances of perovskite materials are strongly influenced by their crystallinity and film morphology. Here, the authors investigate the formation and morphology evolution mechanisms of lead halide perovskites and reveal that bulk polycrystals grow from intermediate [PbI6]⁴⁻cage nanoparticles.

An echomyography system based on a single transducer can be integrated into a wearable patch and used to monitor breathing patterns and hand gestures.

The gut microbiome regulates behaviour in a number of species. Here the authors show that depletion of the gut microbiome in Drosophila reduced aggressive behaviour, in an octopamine-dependent manner.

Dietary zinc and plant-derived aryl hydrocarbon receptor (AHR) agonists are involved in maintaining intestinal epithelium integrity. The authors show that combined supplementation with AHR ligands and zinc might be effective in preventing inflammatory gut disorders.

METTL3 catalyzes mRNA m⁶A deposition. The authors identify an acetylation-mediated regulation of METTL3 subcellular localization and compartment-specific functions, a process that is fine-tuned by anti-inflammatory and pro-inflammatory signals, which ultimately determine breast cancer metastasis.

Short-read sequencing has inherent limitations in the characterisation of long repeat elements. Shi and Guo et al.combine single-molecule real-time sequencing and IrysChip to construct a Chinese reference genome that fills many gaps in the reference genome, and identify novel spliced genes.

Validation of the safety and performance of a wearable ultrasound sensor for the monitoring of blood pressure in clinical settings showed that the sensor met established safety and accuracy requirements.

T-acute lymphoblastic leukemia is an aggressive cancer. Here the authors provide insights into the functional role of SHQ1, an H/ACA snoRNP assembly factor involved in snRNA pseudouridylation, in T-lymphoblastic leukemia cell survival through regulating the maturation of MYC mRNA.

Endoplasmic reticulum (ER) stress promotes cardiac dysfunction. Here the authors uncover a pathway whereby AGGF1 blocks ER stress by inhibiting ERK1/2 activation and the transcriptional repressor ZEB1, leading to induction of miR-183-5p and down-regulation of CHOP, and show that AGGF1 can effectively treat cardiac hypertrophy and heart failure.

Stress granules (SGs) are dynamic compartments with a poorly characterized transition in composition and function during prolonged stress. In this study, the authors investigated the dynamic changes in SG constituents during acute to prolonged heat shock using time-resolved proteomic profiling.

The DAWN study is a phase 3 clinical trial that demonstrates effective glycemic control of dorzagliatin as an add-on therapy to metfomin in patients with type 2 diabetes.

MXenes have emerged as potential antimicrobial materials. Here, the authors report on the creation of a Schottky junction to increase the charge separation between MXenes and semiconductor to increase photodynamic creation of reactive oxygen species under near infrared irradiation for antibacterial purposes.

Major royal jelly protein 1 (MRJP1) is the most abundant glycoprotein in royal jelly (RJ). Here the authors isolated MRJP1 from RJ and determined the 2.65 Å resolution crystal structure of the 16-molecule oligomer, which also contained 24-methylenecholesterol and apisimin bound to MRJP1.

Bone regeneration is of interest for treating a wide range of medical conditions. Here, the authors report on bioinspired matrix vesicles loaded with black phosphorus nanosheets and cell-specific aptamers for bone regeneration and demonstrate bone defect repair in vivo.

Bone implants with antibacterial and osteogenic properties are important for clinical applications, but creating both properties simultaneously remains challenging. Here, the authors demonstrate a self-activating implant using a hydroxyapatite and molybdenum disulfide coating which accelerates bone regeneration and at the same time prevents bacterial infection.

Large whole-exome sequencing studies have suggested that the genetic architecture of syndromic congenital heart disease (CHD) is different from sporadic forms. Here, Watkins et al. estimate the relative contribution of damaging recessive and de novo genotypes to CHD in 2391 trios and find them to be associated with different gene functions.

Bin Han and colleagues performed low-coverage sequencing of 517 rice landraces and constructed a high-density haplotype map of the rice genome. They have used this resource to carry out genome-wide association studies for 14 agronomic traits and identify 80 loci with strong association signals.