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vdW assembly of low-dimensional materials has proven the capability of creating structures with on-demand properties. Here, the authors report on the structural collapse of CNTs in conjunction with a metal-semiconductor junction induced by the VdW encapsulation.

Methods that enable the cleavage of Si−C(sp³) bonds catalytically remain rare. Here the authors report the synthesis of spirosilacycles via palladium-catalysed spiro-sila-cyclization of trialkylsilane derivatives; the reaction proceeds via cleavage of a C(sp³)−Si bond and insertion of an alkylpalladium complex.

Despite great success in generation of ultralong organic phosphorescence (UOP) by suppressing non-radiative transitions through attractive interactions, consideration of repulsive interactions on UOP remains largely unexplored. Here, the authors introduce carboxyl groups into organic phosphors, enabling formation of the intense repulsive interactions between the isolated molecules and the matrix in rigid environment.

Fu et al. describe a pathogen effector, HaRxL10 that suppresses plant immunity and interferes with plant development by hijacking the clock component CHE to perturb its function in transcriptional regulation.

Genome interpretation and analysis of allelic activity requires appropriate haplotype phasing. Here the authors present phASER, a fast and accurate method for variant phrasing from RNA-seq and genome sequencing data.

Short-read sequencing has inherent limitations in the characterisation of long repeat elements. Shi and Guo et al.combine single-molecule real-time sequencing and IrysChip to construct a Chinese reference genome that fills many gaps in the reference genome, and identify novel spliced genes.

The enantioselective synthesis of silicon-stereogenic vinylsilanes from simple alkenes remains underexplored. Here the authors report the enantioselective method from simple alkenes to yield linear silicon-stereogenic vinylsilanes with good yields and enantiomeric ratios under rhodium catalysis.

The authors identify one emerging H2N2 AIV, reveal the molecular basis of human-type receptor binding of the H2N2 AIV and pandemic strains, and evaluate the public risk of H2N2 AIV by its infection, transmission and mammalian-adaptation features.

Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al.conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout.

Reaching the depths of the respiratory tract is hard even with vapor-based drug delivery. Here, the authors devise inhalable biohybrid microrobots that, thanks to their motility, reach deeper regions of the lungs.

Using metagenomics sequencing, Zhang et al. examined sex- and age-dependent trajectories of the gut microbiota in four cohorts across China, Israel and the Netherlands. The authors found age-related gut microbial trajectories common across all populations, with the abundance of Streptococcus gordonii predicting chronological age.

The SARS-CoV-2 Omicron variant spreads rapidly. Here the authors show that Omicron S preferentially adopts the one-RBD-up conformation, which leads to a non-RBM-binding monoclonal antibody escape. Mutagenesis reveals that S371L, S373P and S375F substitutions enhance the conformational stability.

Genes and circuits involved in sleep and sexual arousal have been extensively studied in Drosophila. Here the authors identify the sex determination genes fruitless and doublesex, and a sex-specific P1-DN1 neuronal feedback that governs the interaction between these competing behaviors

Rapid degradation inducing overdose toxicity remains challenging in porous biodegradable bone scaffolds. Here the authors present multiscale architecture design on ZnLi scaffolds with 90% porosity orchestrates immune responses and subsequent bone regeneration.

Infection is a growing issue in artificial implants and has become an area of significant interest. Here, the authors report on graphdiyne titanium dioxide composite nanofibres with enhanced photocatalytic reactive oxygen species generation and osteoinductive properties, demonstrated in infected implant models.

Characterizing the soft protein corona on nanoparticles i.e. the outer layer of the corona, remains a longstanding challenge. Here, the authors develop an in situ method to monitor the dynamic processes of multilayered corona formation and evolution that offers a universal strategy to characterize the soft corona proteome.

Human cerebellar development is fundamentally linked to its function. Here, the authors combine single-cell transcriptomics, spatial transcriptomics, and single-cell chromatin accessibility states to systematically depict an integrative spatiotemporal landscape of human fetal cerebellar development.

The practical application of sodium-ion batteries at subzero temperatures is hindered by the slow Na-ion transfer kinetics. Here, the authors reported the niobium doping of P2-type cathode active material capable of efficient battery cycling at low temperatures such as −40 °C.

The DAWN study is a phase 3 clinical trial that demonstrates effective glycemic control of dorzagliatin as an add-on therapy to metfomin in patients with type 2 diabetes.

Chen et al. report that the immune modulatory metabolite itaconic acid selectively inhibits the activity of TET DNA dioxygenases to repress the inflammatory responses.

A strategy to confine phosphorescent organic chromophores within ionic crystals proves effective in suppressing non-radiative recombination channels and increasing the phosphorescence efficiency of blue-emitting heavy-atom-free emitters.

Gboxin and its chemical derivatives inhibit the growth of primary human and mouse glioblastoma cells, but not of mouse embryonic fibroblasts or neonatal astrocytes, by targeting mitochondrial oxidative phosphorylation complexes.

METTL3 catalyzes mRNA m⁶A deposition. The authors identify an acetylation-mediated regulation of METTL3 subcellular localization and compartment-specific functions, a process that is fine-tuned by anti-inflammatory and pro-inflammatory signals, which ultimately determine breast cancer metastasis.

Primary dysmenorrhoea, the most common gynaecologic complaint, remains genetically and pathophysiologically elusive. Here, Li and colleagues identify common variants inZMIZ1 and near NGFconferring risk for primary dysmenorrhoea using genome-wide association study in a Chinese population.

Here, by performing multi-omics microbiome analyses in a cohort of children with new-onset T1D, the authors characterize altered microbial functional and metabolic traits involved in T1D, which they validate in animal experiments, together providing potential avenues for microbiome-based interventions.

A major challenge of spintronics is achieving magnetic field free electrical control of magnetisation. Here, Xie et al. achieve perpendicular magnetisation switching in a CoPt alloy, breaking inversion symmetry by varying the composition of the alloy in the growth direction.

The treatment of inflammatory arthritis by local delivery of therapeutics is limited by short half-lives of drugs. Here the authors demonstrate a hydrogel platform that titrates drug release to arthritis activity.

In vitro chemotactic assays are often 2D, low-throughput and lack fine gradient control. Here the authors present a hydrogel-based microfluidic platform for high-throughput 3D chemotactic assays, and use it to study neuronal sensitivity to guidance molecule gradient steepness.

A novel stainless-steel pin has been engineered with a pure magnesium core that promotes improved fracture healing in rats by inducing local production of a key neuropeptide for osteogenesis.

A genome-wide association study for attention deficit/hyperactivity disorder (ADHD) identifies 12 loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.

The Cancer Genome Atlas presents an integrative genome-wide analysis of genetic alterations in 279 head and neck squamous cell carcinomas (HNSCCs), which are classified by human papillomavirus (HPV) status; alterations in EGFR, FGFR, PIK3CA and cyclin-dependent kinases are shown to represent candidate targets for therapeutic intervention in most HNSCCs.

Comprehensive analyses of 178 lung squamous cell carcinomas by The Cancer Genome Atlas project show that the tumour type is characterized by complex genomic alterations, with statistically recurrent mutations in 11 genes, including TP53 in nearly all samples; a potential therapeutic target is identified in most of the samples studied.