In this study, the authors show that the RNA repair and splicing pathway regulates axon regeneration in the nervous system of Drosophila. Rtca, a RNA cyclase, is a potent inhibitor of CNS axon regeneration, whereas Archease, a RNA splicing cofactor, functions downstream of Rtca as a pro-regeneration factor. Together, they modify the splicing of Xbp1 in the regulation of axon regeneration.
- Yuanquan Song
- David Sretavan
- Yuh Nung Jan