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Showing 51–73 of 73 results
Advanced filters: Author: Yuh Nung Jan Clear advanced filters

  • In adult Drosophila, the sense of touch is mediated by mechanosensory organs, namely tactile bristles in the epidermis. A new study reveals that a previously unknown type of epidermal cell, named the F-cell, is recruited to ensheath the tactile bristle and is required for touch sensing.

    • Ruijun Zhu
    • Yuh Nung Jan
    News & Views
    Nature Cell Biology
    Volume: 25, P: 518-519

  • The coordinated action of several conserved multiprotein complexes establishes polarity in an asymmetrically dividing cell. How apically localized cues affect the basal distribution of proteins has remained unclear. However, new studies provides a direct link between the two poles, showing that the apical Par6–aPKC complex directly regulates Lethal giant larvae (Lgl).

    • Nicholas J. Justice
    • Yuh Nung Jan
    News & Views
    Nature Cell Biology
    Volume: 5, P: 273-274

  • Single-particle electron cryo-microscopy analysis of the mechanotransduction channel NOMPC reveals that it contains a bundle of four helical spring-shaped ankyrin repeat domains that undergo motion, potentially allowing mechanical movement of the cytoskeleton to be coupled to the opening of the channel.

    • Peng Jin
    • David Bulkley
    • Yifan Cheng
    Research
    Nature
    Volume: 547, P: 118-122

  • The perfection of a fly's eye and the chaotic nature of tumours provide eloquent examples of the need to coordinate cell death and proliferation. The intricacies of the underlying mechanism are now being uncovered.

    • Michael E. Rothenberg
    • Yuh-Nung Jan
    News & Views
    Nature
    Volume: 425, P: 469-470

  • The appropriate targeting of voltage-gated ion channels is essential for the normal functioning of neurons. Lai and Jan review the mechanisms involved in the trafficking and retention of these channels, and discuss how their localization affects neuronal activity.

    • Helen C. Lai
    • Lily Y. Jan
    Reviews
    Nature Reviews Neuroscience
    Volume: 7, P: 548-562

  • Asymmetric cell division is a fundamental process by which cells give rise to progenies with different fates. Although this mechanism is well studied in the worm and fly, mammalian asymmetric cell division is poorly understood. The finding that Gβγ and AGS3 can control mitotic spindle orientation and progenitor cell fates during mouse cortical development suggests evolutionarily conserved roles in asymmetric cell division.

    • Chay T. Kuo
    • Yuh-Nung Jan
    News & Views
    Nature Cell Biology
    Volume: 7, P: 858-859

  • Pathogens block or subvert host cellular processes to promote successful infection. One host protein that is targeted by invading pathogens is the small GTPase RAB11, which functions in vesicular trafficking. Bier and colleagues discuss the various mechanisms that pathogens have evolved to disrupt or subvert RAB11-dependent pathways as part of their infection strategy.

    • Annabel Guichard
    • Victor Nizet
    • Ethan Bier
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 624-634

  • This Review discusses the role of BMP signalling in neural patterning. Comparative evo–devo analyses show that this genetic system has a conserved function in organizing the developing central nervous system and that it was probably already present in the bilaterian ancestor.

    • Claudia Mieko Mizutani
    • Ethan Bier
    Reviews
    Nature Reviews Genetics
    Volume: 9, P: 663-677

  • The brain is particularly sensitive to changes in cell number, which can acutely affect neural function. Here, Knoblich and colleagues describe the proliferation control mechanisms that exist inDrosophila melanogasterand mammals, and their regulation by developmental age and by metabolic and nutritional status.

    • Catarina C. F. Homem
    • Marko Repic
    • Jürgen A. Knoblich
    Reviews
    Nature Reviews Neuroscience
    Volume: 16, P: 647-659

  • During development, boundaries between groups of cells that express different genes need to be established and maintained so that tissues can be patterned. This Review discusses the range of mechanisms — from feedback loops to physical forces — that have emerged as important for developmental boundaries.

    • Christian Dahmann
    • Andrew C. Oates
    • Michael Brand
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 43-55