Nature Search

PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation

Interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II (CAMK2) phosphorylates phosphoserine aminotransferase 1 (PSAT1) at serine 337 (S337), enabling glutathione peroxidase 4 (GPX4) interaction, promoting α-ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation and stabilizing GPX4 to counteract ferroptosis.

Peixiang Zheng
Zhiqiang Hu
Daqian Xu
Research25 Apr 2025
Nature Chemical Biology

P: 1-13
Numerical simulation of ellipse liquid jet atomization in supersonic crossflow

Donglong Zhou
Yuli Li
Jianlong Chang
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-18
Bioinformatic and genomic analysis identifies C allele of APOE rs7412 as the most prominent variant limiting extreme human longevity

Rahmat Dani Satria
Usi Sukorini
Chiou-Feng Lin
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-17
ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation

Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate lyase (ADSL) binds to Beclin1 upon lipid deprivation. ADSL-produced fumarate increases Beclin1 K117 dimethylation by inhibiting lysine demethylase 8 activity, resulting in disrupted binding of BCL-2 to Beclin1, enhanced autophagy and liver tumor growth.

Lei Wang
Runze Shi
Daqian Xu
Research29 Jan 2025
Nature Chemical Biology

Volume: 21, P: 894-905
Publisher Correction: Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis

Man Ting Au
Junguo Ni
Chunyi Wen
Amendments and Corrections16 Sept 2024
Nature Microbiology

Volume: 9, P: 3391
Glecirasib in KRAS^G12C-mutated nonsmall-cell lung cancer: a phase 2b trial

In a single-arm phase 2b trial, glecirasib, an oral KRAS-G12C inhibitor, had an overall response rate of 47.9% in patients with locally advanced or metastatic KRAS^G12C-mutated nonsmall-cell lung cancer.

Yuankai Shi
Jian Fang
Zhiyue Rao
Research06 Jan 2025
Nature Medicine

Volume: 31, P: 894-900
IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma

The role of human glioma IDH1 mutations in regulation of antiviral response is unclear. Here, the authors show that D2HG produced by mutant IDH1 inhibits IFN antiviral responses in glioma cells, which confers sensitivity to oncolytic virotherapy.

Xueqin Chen
Jun Liu
Haipeng Zhang
ResearchOpen Access25 Oct 2023
Nature Communications

Volume: 14, P: 1-15
Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis

Endothelin-1 activation after SARS-CoV-2 infection leads to vascular permeability, chondrocyte senescence, osteoclast activation and cyst formation in affected joints of hamsters, which can be alleviated using macitentan. Joint injury was also seen in two patients after COVID-19 infection.

Man Ting Au
Junguo Ni
Chunyi Wen
Research11 Sept 2024
Nature Microbiology

Volume: 9, P: 2538-2552
Cell-type-specific PtrWOX4a and PtrVCS2 form a regulatory nexus with a histone modification system for stem cambium development in Populus trichocarpa

This study revealed a regulatory system in which transcription factor and histone acetylation functions are coordinated for maintaining normal stem vascular cambium development for wood formation in Populus trichocarpa.

Xiufang Dai
Rui Zhai
Wei Li
ResearchOpen Access09 Jan 2023
Nature Plants

Volume: 9, P: 96-111
Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function

Wu et al. show that, upon activation by insulin-like growth factor 1 receptor and AKT, creatine kinase B exhibits a moonlighting function as protein kinase to phosphorylate glutathione peroxidase 4 to prevent its degradation, thereby suppressing ferroptosis and enhancing tumour growth in mice.

Ke Wu
Meisi Yan
Daqian Xu
Research08 May 2023
Nature Cell Biology

Volume: 25, P: 714-725
Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth

Wang and colleagues identify a protein phosphatase role for the metabolic enzyme fructose-1,6-bisphosphatase 1 that, upon phosphorylation by PERK, dephosphorylates histone H3 and modulates PPARα-mediated gene expression to inhibit liver cancer progression.

Zheng Wang
Min Li
Zhimin Lu
Research20 Oct 2022
Nature Cell Biology

Volume: 24, P: 1655-1665
Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth

Liu et al. demonstrate that CK2 phosphorylates CLOCK to promote its nuclear exportation and cytosolic accumulation, thereby acetylating and stabilizing PRPS1/2 and enhancing de novo nucleotide synthesis to facilitate liver tumour growth.

Tong Liu
Zheng Wang
Daqian Xu
Research16 Jan 2023
Nature Cell Biology

Volume: 25, P: 273-284
Effect of temperature on the dynamic parameters of silty clay in a seasonally frozen region

Haotian Guo
Yuli Lin
Jinfeng Li
ResearchOpen Access12 Aug 2023
Scientific Reports

Volume: 13, P: 1-9
Metabolic remodelling during early mouse embryo development

By using an integrated omics approach, a landscape of metabolic remodelling of early-stage mouse embryogenesis is reconstructed, identifying key metabolites for epigenetic reprogramming.

Jing Zhao
Ke Yao
Jin Zhang
Research14 Oct 2021
Nature Metabolism

Volume: 3, P: 1372-1384
Scallop genome provides insights into evolution of bilaterian karyotype and development

The genome of the scallop Patinopecten yessoensis is sequenced. This bivalve mollusc has a slow-evolving genome with features such as karyotype and Hox gene expression that may be close to that of the ancestral bilaterian.

Shi Wang
Jinbo Zhang
Zhenmin Bao
ResearchOpen Access03 Apr 2017
Nature Ecology & Evolution

Volume: 1, P: 1-12
Associations of decayed teeth and localized periodontitis with mental stress in young adults: CHIEF oral health study

Kun-Zhe Tsai
Sung-Chiao Tsai
Gen-Min Lin
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-7
Sacubitril/valsartan ameliorates cardiac function and ventricular remodeling in CHF rats via the inhibition of the tryptophan/kynurenine metabolism and inflammation

Jiali Gan
Yuli Wang
Lili Song
ResearchOpen Access29 May 2024
Scientific Reports

Volume: 14, P: 1-12
Activation of p53 transcriptional activity by 1,10-phenanthroline, a metal chelator and redox sensitive compound

Yi Sun
Junhui Bian
Christine Jacobs
Research30 Jan 1997
Oncogene

Volume: 14, P: 385-393
Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis

Yuli Lin
Bingji Li
Rui He
ResearchOpen Access18 Sept 2019
Mucosal Immunology

Volume: 12, P: 1304-1315
Computational pathology improves risk stratification of a multi-gene assay for early stage ER+ breast cancer

Yuli Chen
Haojia Li
Anant Madabhushi
ResearchOpen Access17 May 2023
npj Breast Cancer

Volume: 9, P: 1-10
Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration

Yuli Lin
Yusheng Chen
Xuguang Yang
ResearchOpen Access15 Mar 2021
Cell Death & Disease

Volume: 12, P: 1-11
Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation

Li Yu, Ya-Ping Zhang, Chung-I Wu and colleagues report the de novo genome of the black snub-nosed monkey Rhinopithecus bieti and the genomic sequences of four other Rhinopithecus species, including three high-altitude and two lowland species. The species- and population-level genomic analyses as well as the transcriptomic analysis and functional assays find adaptive signatures associated with adaptation to high altitude.

Li Yu
Guo-Dong Wang
Ya-Ping Zhang
ResearchOpen Access11 Jul 2016
Nature Genetics

Volume: 48, P: 947-952
Plasmacytoid dendritic cells promote acute kidney injury by producing interferon-α

Bo Deng
Yuli Lin
Feng Ding
Research03 Jan 2020
Cellular & Molecular Immunology

Volume: 18, P: 219-229
Gene–gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics

Y-J Liou
Y M Bai
S-J Tsai
Research28 Sept 2010
The Pharmacogenomics Journal

Volume: 12, P: 54-61
Association between previous history of gout attack and risk of deep vein thrombosis - a nationwide population-based cohort study

Chun-Chih Chiu
Yung-Tai Chen
Shing-Jong Lin
ResearchOpen Access27 May 2016
Scientific Reports

Volume: 6, P: 1-7
Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation

Yuli Li
Ruijia Wang
Shi Wang
ResearchOpen Access26 Jun 2018
Cell Discovery

Volume: 4, P: 1-17
Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer

Lisha Zhou
Yanyu Jiang
Lijun Jia
Research26 Jun 2019
Oncogene

Volume: 38, P: 5792-5804
Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization

Yuli Lin
Xuguang Yang
Rui He
ResearchOpen Access14 Apr 2014
Cellular & Molecular Immunology

Volume: 11, P: 355-366
County-level CO₂ emissions and sequestration in China during 1997–2017

Jiandong Chen
Ming Gao
Yuli Shan
ResearchOpen Access12 Nov 2020
Scientific Data

Volume: 7, P: 1-12
Effect of noisy galvanic vestibular stimulation on dynamic posture sway under visual deprivation in patients with bilateral vestibular hypofunction

Po-Yin Chen
Ying-Chun Jheng
Chung-Lan Kao
ResearchOpen Access19 Feb 2021
Scientific Reports

Volume: 11, P: 1-10
The Impact of Blood Transfusion on Recurrence and Mortality Following Colorectal Cancer Resection: A Propensity Score Analysis of 4,030 Patients

Hsiang-Ling Wu
Ying-Hsuan Tai
Kuang-Yi Chang
ResearchOpen Access06 Sept 2018
Scientific Reports

Volume: 8, P: 1-8
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade

Yuan Li
Qi Zhan
Yu Li
ReviewsOpen Access28 Jun 2021
International Journal of Oral Science

Volume: 13, P: 1-19

Search

PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation

Numerical simulation of ellipse liquid jet atomization in supersonic crossflow

Bioinformatic and genomic analysis identifies C allele of APOE rs7412 as the most prominent variant limiting extreme human longevity

ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation

Publisher Correction: Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis

Glecirasib in KRAS^G12C-mutated nonsmall-cell lung cancer: a phase 2b trial

IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma

Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis

Cell-type-specific PtrWOX4a and PtrVCS2 form a regulatory nexus with a histone modification system for stem cambium development in Populus trichocarpa

Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function

Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth

Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth

Effect of temperature on the dynamic parameters of silty clay in a seasonally frozen region

Metabolic remodelling during early mouse embryo development

Scallop genome provides insights into evolution of bilaterian karyotype and development

Associations of decayed teeth and localized periodontitis with mental stress in young adults: CHIEF oral health study

Sacubitril/valsartan ameliorates cardiac function and ventricular remodeling in CHF rats via the inhibition of the tryptophan/kynurenine metabolism and inflammation

Activation of p53 transcriptional activity by 1,10-phenanthroline, a metal chelator and redox sensitive compound

Non-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis

Computational pathology improves risk stratification of a multi-gene assay for early stage ER+ breast cancer

Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration

Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation

Plasmacytoid dendritic cells promote acute kidney injury by producing interferon-α

Gene–gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics

Association between previous history of gout attack and risk of deep vein thrombosis - a nationwide population-based cohort study

Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation

Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer

Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization

County-level CO₂ emissions and sequestration in China during 1997–2017

Effect of noisy galvanic vestibular stimulation on dynamic posture sway under visual deprivation in patients with bilateral vestibular hypofunction

The Impact of Blood Transfusion on Recurrence and Mortality Following Colorectal Cancer Resection: A Propensity Score Analysis of 4,030 Patients

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade

Search

Quick links

Search

Filter By:

Search

Quick links