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In a large-scale, international, multicenter, phase 1/1b trial, treatment of patients with advanced solid tumors with the B7H3-targeting antibody–drug conjugate YL201 was safe and showed preliminary clinical efficacy.

A two-phase assembly approach is developed to synthesize single-unit-cell-thick perovskite chains within single-walled carbon nanotubes. A direct X-ray detector constructed with the confined perovskite chains exhibits outstanding performance and ultrahigh stability under harsh conditions.

Workers in social insects such as honey bees, bumble bees, and ants are expected to spend their lives helping their mother reproduce. Here the authors show that workers of several bumble bee species can in fact mate and lead colonies of their own.

Here the authors investigated DHX36-induced RNA structurome changes by conducting Structure-seq and uncovered that DHX36 binding-induced 3’UTR structural accessibility enhances m6A dependent YTHDF1 binding to promote target mRNA degradation.

A study describes the development of a generalizable foundation machine learning framework to extract pathology imaging features for cancer diagnosis and prognosis prediction.

Clinical evidence suggests that debulking surgery in patients with metastatic disease could enhance response to immune checkpoint therapy. Here the authors report the results of a clinical trial of immune checkpoint inhibitors plus debulking surgery in patients with metastatic renal cell carcinoma.

Deng et al. expand the toolbox of neurotransmitter sensors with high-sensitivity green and red genetically encoded serotonin sensors. These are suitable for in vivo applications, as demonstrated in a variety of applications in mice.

The mechanism of high-temperature superconductivity in the iron-based materials remains not fully understood. Here, the authors report on ARPES measurements on an FeSe-based bulk superconductor, whose electronic properties are found to be similar to those of single-layer FeSe/STO films.

The authors present a simple and rapid way for fabricating gold microsphere arrays through a laser-irradiated ripening strategy. These gold microspheres are suitable for reliable high-resolution bonding applications due to their stable conductivity.

Next-generation red and green G-protein-coupled receptor-based dopamine sensors with improved properties have been developed. Their performance is demonstrated in cell culture, in brain slices and in vivo in the mouse.

Assembly is an interesting strategy to build chiral hierarchies with premade properties and functionalities. Here, the authors present assembled chiral hydrogen-bonded organic-inorganic frameworks with dynamical chiroptical activities and employ them as powerful and recoverable platforms for enantioselective recognition of chiral aliphatic substrates.

Moso bamboo is an economically and ecologically important nontimber forestry species. Here, the authors analyze 427 genomes collected from 15 representative geographic areas, and identify genes under balancing selection, putative patterns of historic demography, and candidate genes associated with important traits.

Orzya meridionalis is a wild rice species that has reproductive isolation with Asian cultivated rice. Here, the authors report the cloning of the second locus controlling hybrid male sterility between the two species and show the encoded toxin-antidote system provides stacked reproductive isolation for maintaining species identity.

Egg-laying performance is an important phenotype for breeding chicken. Here, the authors explore the regulatory networks driving phenotypic differences in egg-laying, and identify laying-related variants and endocrine factors.

The ability to manipulate the flux of ions across membranes is a key aspect of diverse sectors including water desalination, blood ion monitoring, purification, electrochemical energy conversion and storage. Here the authors illustrate the potential of using daily changes in environmental humidity as a continuous driving force for generating selective ion flux.

DeepCAD-RT denoises fluorescence time-lapse images in real time.

The preparation of systems that give blue circularly polarised organic afterglow is desirable but challenging. Here, the authors confine a chiral chromophore within a polymer matrix to limit non-radiative transitions and give blue circularly polarised organic afterglow.

Transcriptome-wide mapping of RNAs bound by human ADARs reveals features that determine ADAR binding affinity and editing efficiency.

An assay that thermophoretically profiles surface proteins from serum extracellular vesicles labelled with a panel of fluorescent aptamers detects and classifies patients according to cancer type and cancer stage.

Recombinant adeno-associated virus tools for enhanced microglial transduction in mice are reported. These viruses can be used to express functional reporters or genome editing tools with high microglial specificity, with the help of microglia-specific Cre lines.

Catalysed oxidative C-C bond formation reactions are important in the synthesis of natural products, but poorly tolerated by polyphenolic flavones. Here the authors report the reactivity of molecular oxygen in alkaline water without added catalyst for the synthesis of a collection of flavone dimers and trimers.

In order to understand the role of formaldehyde in living systems, real-time monitoring is required. Here the authors report a genetically encoded, reaction-based formaldehyde sensor (FAsor) that enables visualisation of formaldehyde in mammalian cells and tissues.

The second messenger cAMP modulates a wide range of important biological processes. Here, the authors developed a fluorescent indicator termed G-Flamp1, which can accurately report levels of cAMP in living cells.

Zhang et al. show that ALK phosphorylates SMAD4 at Tyr 95 to block its binding to DNA, representing a mutation-independent mechanism for blocking the tumour suppressor function of TGF-β in ALK-positive cancers.

Single cell transcriptomic sequencing (scRNA) can identify genes that are differentially expressed in cell populations in specific diseases. Here the authors perform scRNA sequencing in a high-altitude pulmonary hypertension (HAPH) cohort and show transcriptional differences in monocyte populations.

A polymeric protein complex consisting of a newly identified magnetoreceptor protein and known magnetoreception-related photoreceptor cryptochromes exhibits spontaneous alignment in magnetic fields.