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Tong et al. describe a super pangenome assembled from long-read sequences of 545 wild and domesticated silkworms. Naturally selected (diapause, aposemantic coloration) or artificially selected (silk yield and fineness) sets of genes are delineated.

Dual targeting of BRAF and MAPK signaling in the BRAF v600E mutant colorectal cancer patients has shown limited efficacy in clinical studies. Here, the authors identify PLK1 inhibition as synthetic lethal with dual BRAF and EGFR inhibition due to loss of ferroptosis inhibition via a PLK1-CBX8-GPX4 signaling axis in preclinical models of colorectal cancer.

A computational framework to integrate microbial GWAS and single-cell RNA-sequencing profiles of 24 human organs reveals interactions between the host cells and microbes.

Cell free RNA is a potentially valuable resource to detect cancer, however, its low concentration in plasma can limit usefulness. Here, the authors devise a library preparation method from 100ul of plasma, and apply to multiple cancer types to detect and classify cancer patients

Fan and colleagues show that the neurotransmitter GABA signals in intestinal ILC3s to suppress IL-17A production through a regulatory loop that involves suppression of C/EBP-β and induction of Igfb7.

A high-throughput yeast display platform is used to analyse the profiles of mutations in the SARS-CoV-2 receptor-binding ___domain (RBD) that enable escape from antibodies, and suggests that most anti-RBD antibodies can be escaped by the Omicron variant.

RNA binding protein Quaking (QKI) is known for its broad function in pre-mRNA splicing and modification and its association with several neurodevelopmental disorders. Here the authors reveal that QKI-mediated regulation of RNA splicing is indispensable to cardiac development and contractile physiology.

Two-dimensional conjugated coordination polymers can show large electrical conductivity. Here, the authors synthesize high-quality single crystals of Cu₃BHT to unveil the atomic structure and intrinsic superconducting properties.

Mild cold exposure activates a substantial amount of brown adipose tissue (BAT) in a patient with cancer, reducing tumour-associated glucose uptake, and activation of BAT in mice inhibits the growth of tumours by decreasing blood glucose and impeding glycolysis-based metabolism in cancer cells.

Manganese complexes have long been utilized by nature to catalyze the oxygen evolution reaction (OER) but mirroring their efficiency in artificial electrochemical systems has proven difficult. This study centers on alpha-manganese dioxide (α-MnO₂), which closely mimics natural Mn^IV-O-Mn^III-H_xO motifs, presenting a novel method for manipulating proton coupling within the OER process using an external electric field.

Whole-slide images (WSI) and digital pathology are valuable approaches for the analysis of tumours and their microenvironments. Here, the authors present scMTOP, a framework to characterise tumour ecosystems and intercellular relationships at the single-cell level from WSIs, which they apply to breast cancer samples.

Through sequencing of 88,005 nuclei from the breast tissues of clinically healthy women of diverse genetic ancestry, a global breast single-nucleus atlas was developed that identifies distinct cell types and ancestry-level differences linked to epithelial and fibroblast cell states, which in turn could influence disease incidence, molecular subtypes and progression.

Anti-VEGF therapy has many limitations that might be resolved by using combination treatment approaches. Here, the authors demonstrate that the dual-targeting of VEGF and PDGF is required for targeting resistant FGF2+ tumors which depend on the recruitment of pericytes on tumor microvessels.

The Ca_V2.3 channel is involved in synaptic plasticity and neurological disorders. Here, authors resolve the human Ca_V2.3 structure to explore functional heterogeneity of VSDs and elucidated the closed- and open-state inactivation mechanisms of the channel.

Na_V1.6 channel plays a critical role in neuronal excitability. Here, authors present human Na_V1.6 structures in apo and 4,9-anhydro-tetrodotoxin bound forms, which reveal molecular mechanisms of Na_V1.6 Na⁺ conductance and inhibition by the blocker.

Elevated IL-33 levels have been correlated with metastasis and poor prognosis. Here the authors show in mouse tumour xenograft models that PDGF-BB produced by tumour cells induces IL-33 via Sox7 in tumour pericytes, and IL-33 promotes metastasis through its effects on tumour-associated macrophages.

TNF-α signalling regulates a range of pathophysiological functions including tumour growth, but its role in lymphatic metastasis is unclear. Here the authors show that TNF-α signalling stimulates lymphatic endothelial cell activity, lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling.

The realization of ultrastable, nanostructured glassy polymer films by pulsed-laser evaporation is reported. Compared with standard poly(methyl methacrylate) glass, these polymer glasses are 40% less dense and have a 40-degree-higher glass transition temperature. Their unique properties, which are a manifestation of their globular nanostructure, should make these glasses attractive for applications where weight and stability are critical.

Tuberculosis is a major global health issue. Here the authors report Mycobacterium-pre-activated macrophage membrane-coated photothermal nanoparticles for targeted tuberculous granuloma and pathogen dual imaging and antibacterial photothermal therapy.

Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours, lymph node metastasis and liver metastasis of ten CRC patients and reveal co-existence of diverse modes of metastasis in the same patient.

Controllable synthesis of higher alcohols from CO hydrogenation remains a great challenge. Here the authors show that potassium-decorated edge-rich MoS₂ enables selective CO hydrogenation to higher alcohols by regulating the reaction kinetics of C-O cleavage, C-C coupling and desorption of alcohols.

After myocardial infarction, dedifferentiated cardiomyocytes secrete the protein Reg3β, thereby recruiting macrophages required for neutrophil clearance and myocardial healing.

Upgrading methane to more valuable chemicals such as methanol is highly appealing but remains challenging. Here the authors show how edge-rich MoS₂ can be used to oxidize methane to C1 oxygenates at room temperature using oxygen as the oxidant.

Electrochemical carbon capture is a promising way to electrify CO₂ emissions mitigation, but capacities are often low due to poor solubility of the redox-active organic molecules at the heart of the process. Here the authors report a high-capacity and high-stability electrochemical CO₂ capture system based on a phenazine derivative they have developed.

Wearable and skin-like X-ray detectors need intrinsic flexibility and high sensitivity. Here Guo et al. develop a stretchable n-type polymer semiconductor with aligned nanofiber networks which achieve photosensitivity of 1.52×10^4 μC Gyair^-1 cm^−2 and low detection limit of 37.7 nGyair s^-1.

Difficulties in separating tribo and piezoelectric hybrid signals can lead to an overestimated contribution of the latter. Here, authors propose a method to separate these hybrid signals in the time ___domain, precisely extracting piezoelectric charge transfer for performance evaluation.

Long noncoding RNAs have been shown to play a role in cardiovascular disease. Here, the authors identify a lncRNA named CCRR, whose downregulation in failing hearts causes cardiac conduction disturbances by altering the endocytic trafficking of Cx43.

In a nested case-control study from the China Kadoorie Biobank, lowering blood low-density lipoprotein cholesterol levels confers lower risk for ischemic stroke but elevated risk for intracerebral hemorrhage, which was confirmed by genetic Mendelian randomization analyses.