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Most methods for the synthesis of three-dimensional covalent organic frameworks need one precursor being extended into three-dimensional space. Here, the authors employ multinode porphyrin blocks with eight rotatable knots to create intermediates with steric hindrance-confined rigid stereoconformations for guiding three-dimensional formation of covalent organic frameworks with high crystallinity.

A red blood cell haemostatic mechanism induced by dying ECs functions independently of platelets and fibrin.

Nf2 physically engages with focal adhesion kinase (FAK) to preferentially mediate Erk1/2 and PI3K catalytic p110 subunit/Akt signaling, regulating osteogenic lineage development, cranial bone ossification and regeneration.

Long-term stability is a key challenge for ruthenium-based oxygen evolution reaction (OER) catalysts. Here, the authors present a RuO2/LiCoO2 catalyst with dynamic Li dissolution, which weakens the covalency of the Ru-O bond to prevent the lattice oxygen mechanism, thereby ensuring stable acidic OER.

Understanding the charge storage mechanism of electrode materials is critical for designing electrochemical energy storage devices. Here, authors study Li⁺ intercalation into two-dimensional metal carbides in nonaqueous electrolytes, revealing distinct behavior for different surface terminations.

Investigating metabolic disturbances in coronary artery disease (CAD) may allow the identifications of new prognostic biomarkers. Here the authors perform a metabolomics study to highlight the shared and distinct metabolites characterizing risks of several cardiovascular events in CAD patients.

Authors perform an in vivo mass spectrometry-based interactome analysis of HOIL-1-interacting protein, a key component of linear ubiquitination assembly complex.

Liu et al. identify downregulation of DDX5, an RNA helicase, in the cartilage of patients and mouse model of osteoarthritis. Targeted upregulation of DDX5 in mouse chondrocytes inhibits hyaline cartilage fibrosis and degradation via pre-mRNA splicing and G4 unwinding, a potential therapeutic strategy against osteoarthritis.

Ge, Zhou, Fu et al. find caspase-2 accumulates in biomolecular condensates with ubiquitin and proteasomal components and functions as a deubiquitinase following stress. Caspase-2-deficient mice accumulate poly-ubiquitinated TDP-43 and show motor defects.

Electrosynthesis via two electron water reactions offers a promising method for decentralized H₂O₂ production, yet its mechanism remains unclear. Here, the authors address the challenge by using in-situ Raman and DEMS, and demonstrate 93% of H₂O₂ forms via the carbonate coupling route through a C₂O₆²⁻ intermediate.

The coordination ability of co-solvents with cationic charge carriers is discussed as a guide for selecting co-solvents for various post-lithium metal batteries. Effects beyond the solvation sheath of cationic charge carriers and the sustainable development of electrolytes are necessary for improving batteries in the future.

Here, the authors report results from a randomized, placebo-controlled phase 3 trial of the tetravalent SARS-CoV-2 protein vaccine SCTV01E, demonstrating a favorable efficacy profile during a time when predominant viral variants were changing from BA.5 and BF.7 to XBB.

Ammonium ion batteries are of growing interest for energy storage research. Here, the authors observe two-step pseudocapacitive storage behavior in an ammonium acetate electrolyte, resulting in a superior ammonium ion storage capacity.

Patients with diabetes often have delayed wound healing, associated with excessive inflammation. Here the authors report that REG3A inhibits TLR3-driven inflammation in skin wounds, and show that REG3A is reduced in models of diabetes, which exacerbates inflammation in diabetic wounds.

Lou and colleagues describe the role of METTL16 in homologous recombination repair and demonstrate that PARP inhibition may be beneficial in the treatment of PDAC that is characterized by high METTL16.

EMS1 is a receptor-like kinase that recognizes the peptide ligand TPD1 to specify tapeta in Arabidopsis. Here, via a reciprocal complementation approach, the authors provide evidence that intracellular signaling by EMS1 is interchangeable with that of the brassinosteroid receptor BRI1.

The practical use of all-solid-state batteries is hindered by inadequate cycling performance. Here, the authors propose a fluorination strategy for the positive electrode and polymeric electrolyte to develop all-solid-state Li||FeF3 pouch cells with high discharge capacity and long cycle life.

Electrochemical methods are promising for monitoring neurochemical dynamics, but are limited by inflammation effects from electrode implantation. Here, the authors report the development of a single-atom catalyst that acts both as an antioxidative nanozyme and an electrode material for the inflammation-free sensing of dopamine in the brain.

Using an integrated analysis on three independent large human datasets, Wang et al. map macroscale dysconnectivity in schizophrenia onto layer- and cell-type-specific microscale alterations. The authors identify different alterations of corticocortical and corticostriatal connectivity in schizophrenia and their relationship to different symptom dimensions and functional domains.

Metabolomics analyses reported an increased risk of cardiovascular disease associated with the artificial sweetener erythritol, supported by mechanistic studies showing that high levels of erythritol enhanced platelet reactivity and thrombosis formation.

Lai and colleagues show that the RNA helicase DDX5 mediates the alternative splicing of the IL-36R mRNA in keratinocytes and modulates skin inflammation downstream of IL-17D signaling.

Very-long-chain fatty acids (VLCFAs) mediate recruitment of septins to the plasma membrane in fungal appressoria, leading to formation of a septin ring at the point of plant infection. VLCFA biosynthesis-inhibiting chemicals prevent septin assembly and have broad-spectrum fungicidal activity.

Aggregation-induced emission (AIE) fluorescence probes are indispensable for biomedical imaging, however, interference with tissue autofluorescence results in low signal-to-noise ratio limiting the development of bioimaging with AIE materials. Here the authors develop AIEgen room-temperature phosphors with long emission lifetimes efficiently eliminating intereference with the background signal in imaging.

The electrode based on ultradispersed sub-10 nm SnO₂ nanocrystals anchored on graphene nanosheets can reversibly store Na ions through both a surface-controlled pseudocapacitive reaction and a diffusion-limited alloying reaction. The fabricated Na ion hybrid capacitor with ultradispersed sub-10 nm SnO₂ nanocrystals anchored on graphene nanosheets as negative electrode exhibits superior electrochemical performance.

The ATR pathway is active during DNA replication stress to maintain genome stability. Here the authors reveal the role of the zinc finger containing protein 161 (ZFP161) to facilitate replication fork stability by acting as a scaffold to facilitate the interaction between RPA and ATR/ATRIP.

High-performance electrocatalysts for the oxygen reduction reaction (ORR) typically use platinum (Pt), however its high cost is a hindrance to commercial scale up. Here, the authors report a cost-effective, efficient and durable Pt single-atom electrocatalyst for ORR with a Pt utilization of 0.13 g_Pt kW⁻¹in a fuel cell.

Redox mediators catalyse the otherwise slow and energy-inefficient cycling of Li–S and Li–O₂ batteries. An investigation of the kinetics of mediated Li₂S and Li₂O₂ oxidations when the redox potentials of various mediators are tuned reveals threshold potentials for high reaction rates, which can be optimized in multiple ways.

The long-noted association of red meat with an increased risk of cardiovascular disease may be due to ingestion of a specific compound found in red meat, l-carnitine. The ability of this compound to promote atherosclerosis in mice requires that it be further metabolized by the gut microbiota. In humans, omnivores but not vegans or vegetarians metabolize l-carnitine in this manner, a difference which may be explained by effects of diet on the presence of specific types of bacteria in the gut.

The past decade has witnessed substantial advances in the synthesis of various electrode materials with three-dimensional (3D) ordered macroporous or mesoporous structures (the so-called “inverse opals”) for applications in electrochemical energy storage devices. Yuping Wu from Nanjing Tech University anchored recent advancements in 3D ordered porous (3DOP) electrode materials and their unusual electrochemical properties bound by their intrinsic and geometric structures. The team introduces various 3DOP electrode materials and their representative applications as electrode materials. Additionally, the team also provides research opportunities as well as the challenges to facilitate further contributions to this emerging research frontier.

Long non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs.

Gallo and his colleagues report that commensal bacteria on the skin help to dampen inflammation caused by skin injury in mice. They show that, after wounding, necrotic cells release RNA that triggers TLR3 on keratinocytes, causing inflammatory cytokine release. Commensal bacteria in the skin suppress this inflammatory response through triggering TLR2 on the keratinocytes.

This paper shows that gut flora can influence cardiovascular disease, by metabolizing a dietary phospholipid. Using a metabolomics approach it is found that plasma levels of three metabolites of dietary phosphatidylcholine—choline, betaine and TMAO—are associated with increased risk of cardiovascular disease in humans. The gut flora is known to have a role in TMAO formation from choline, and this paper shows that dietary choline supplementation enhances macrophage foam cell formation and lesion formation in atherosclerosis-prone mice, but not if the gut flora are depleted with antibiotics.

RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates RAP80 after DNA damage, prompting recruitment to the break site.