Dual-responsive disassembly of core-shell nanoplatform (Au@MPN) is reported with self-supplied H2O2 and autocatalytic Fenton reaction for enhanced chemodynamic therapy. Both ATP and low pH can disassemble the Au@MPN to release Fe(III), which can then be reduced into Fe(II) by the simultaneously released tannic acid. In particular, the exposed gold nanoparticles can catalyze the oxidation of intracellular glucose to produce H2O2. Subsequently, Fe(II) and the self-supplied H2O2 induce an efficient Fenton reaction for chemodynamic therapy by generating hydroxyl radicals. Additionally, tumor growth and melanoma metastatic lung cancer can be effectively suppressed by Au@MPN.
- Mengran Peng
- Enguo Ju
- Mingqiang Li
