Nature Search

Atlas of imprinted and allele-specific DNA methylation in the human body

DNA methylation drives parental expression differences at imprinted genes. Here, the authors uncover hundreds of ubiquitous and tissue-specific differentially methylated regions, offering insights into parental regulation and disease inheritance.

Jonathan Rosenski
Ayelet Peretz
Tommy Kaplan
ResearchOpen Access11 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Yuval Dor
Juliana Brown
Douglas A. Melton
Research06 May 2004
Nature

Volume: 429, P: 41-46
Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Peter Carmeliet
Yuval Dor
Eli Keshert
Amendments and Corrections01 Oct 1998
Nature

Volume: 395, P: 525
β-cell proliferation is the major source of new pancreatic β cells

New insulin-producing β cells are produced throughout adult life and could potentially be exploited in regenerative therapies for diabetes. Although pancreatic progenitor cell differentiation has been proposed to drivede novoβ-cell generation, this Viewpoint argues that new β cells arise from the proliferation of pre-existing β cells.

Yuval Dor
Reviews01 May 2006
Nature Clinical Practice Endocrinology & Metabolism

Volume: 2, P: 242-243
Author Correction: ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Ronen Sadeh
Israa Sharkia
Nir Friedman
Amendments and Corrections21 Jan 2021
Nature Biotechnology

Volume: 39, P: 642
Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Luc Baeyens
Marie Lemper
Harry Heimberg
Amendments and Corrections17 Feb 2020
Nature Biotechnology

Volume: 38, P: 374
DNA-sensing inflammasomes cause recurrent atherosclerotic stroke

This study describes sensing of circulating cell-free DNA after stroke as the mechanism leading to recurrent ischemic events.

Jiayu Cao
Stefan Roth
Arthur Liesz
ResearchOpen Access07 Aug 2024
Nature

Volume: 633, P: 433-441
A DNA methylation atlas of normal human cell types

We describe a human DNA methylome atlas based on deep whole-genome bisulfite sequencing, allowing fragment-level analysis of cell-type-specific markers and providing an essential resource for studies of gene regulation and for deconvolution of cell mixtures and liquid biopsies.

Netanel Loyfer
Judith Magenheim
Tommy Kaplan
ResearchOpen Access04 Jan 2023
Nature

Volume: 613, P: 355-364
Megakaryocyte- and erythroblast-specific cell-free DNA patterns in plasma and platelets reflect thrombopoiesis and erythropoiesis levels

Circulating cell-free DNA (cfDNA) has diagnostic potential, and clarifying its origins will aid in the minimally-invasive detection and monitoring of disease. Here, authors find that physiologically, megakaryocytes are major sources of cfDNA, while erythroblasts also release small amounts of cfDNA.

Joshua Moss
Roni Ben-Ami
Yuval Dor
ResearchOpen Access20 Nov 2023
Nature Communications

Volume: 14, P: 1-10
p16^Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

As beta cells age their levels of p16 rise, and the cells become senescent; rather than leading to dysfunction, this results in an increased capacity of the beta cells for glucose-stimulated insulin secretion.

Aharon Helman
Agnes Klochendler
Ittai Ben-Porath
Research07 Mar 2016
Nature Medicine

Volume: 22, P: 412-420
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Peter Carmeliet
Yuval Dor
Eli Keshet
Research30 Jul 1998
Nature

Volume: 394, P: 485-490
Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity

Pancreatic ductal adenocarcinoma may be initiated by acinar metaplasia, but the molecular and cellular insights during this transition are unclear. Here the authors show, using single cell RNA-sequencing analyses, that mouse metaplastic acinar cells can be clustered into six cell types or states that are heterogeneous and have unique transcription programs.

Yehuda Schlesinger
Oshri Yosefov-Levi
Oren Parnas
ResearchOpen Access09 Sept 2020
Nature Communications

Volume: 11, P: 1-18
The activating receptor NKp46 is essential for the development of type 1 diabetes

Natural killer cells infiltrate the pancreas during type 1 diabetes. Mandelboim and co-workers find that the natural killer receptor NKp46 recognizes ligands on pancreatic beta cells and is essential for full diabetes development.

Chamutal Gur
Angel Porgador
Ofer Mandelboim
Research20 Dec 2009
Nature Immunology

Volume: 11, P: 121-128
ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Circulating cell-free DNA from patients is analyzed by ChIP-seq to reconstruct gene expression in human organs and tumors.

Ronen Sadeh
Israa Sharkia
Nir Friedman
Research11 Jan 2021
Nature Biotechnology

Volume: 39, P: 586-598
Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA

The detection of cardiomyocyte death is a critical aspect in the diagnosis and monitoring of heart diseases. Here the authors show that cardiomyocyte-specific methylation patterns of circulating cell-free DNA may serve as a biomarker of cardiac cell death in infarcted and septic patients.

Hai Zemmour
David Planer
Yuval Dor
ResearchOpen Access24 Apr 2018
Nature Communications

Volume: 9, P: 1-9
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Veerle Compernolle
Koen Brusselmans
Peter Carmeliet
Research10 Jun 2002
Nature Medicine

Volume: 8, P: 702-710
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis.

Melissa F. Brereton
Maria Rohm
Frances M. Ashcroft
ResearchOpen Access24 Nov 2016
Nature Communications

Volume: 7, P: 1-15
EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia

The exosome is responsible for mRNA degradation, which is an important step in the regulation of gene expression. Here the authors report that homozygous missense mutations in the exosome subunit, EXOSC8, may cause neurodegenerative disease in infants through the dysregulation of myelin expression.

Veronika Boczonadi
Juliane S. Müller
Rita Horvath
ResearchOpen Access03 Jul 2014
Nature Communications

Volume: 5, P: 1-13
Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway

Morito Sakikubo
Kenichiro Furuyama
Yoshiya Kawaguchi
ResearchOpen Access25 Oct 2018
Scientific Reports

Volume: 8, P: 1-10
Author Correction: ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Ronen Sadeh
Israa Sharkia
Nir Friedman
Amendments and Corrections01 Mar 2021
Nature Biotechnology

Volume: 39, P: 642
Publisher Correction: Building an international consortium for tracking coronavirus health status

Eran Segal
Feng Zhang
Paul Wilmes
Amendments and Corrections26 Jun 2020
Nature Medicine

Volume: 26, P: 1309
Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability

Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, the authors perform genome- and epigenome-wide analyses from normal and ACC pancreatic tissue that identify aberrations in genome stability and cell cycle control.

Cornelia Jäkel
Frank Bergmann
Peter Schmezer
ResearchOpen Access06 Nov 2017
Nature Communications

Volume: 8, P: 1-10
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reveals tissue contributions that agree with clinical findings.

Joshua Moss
Judith Magenheim
Yuval Dor
ResearchOpen Access29 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Short-term treatment with cytokines reprograms acinar cells into beta cells and restores durable normoglycemia in diabetic mice.

Luc Baeyens
Marie Lemper
Harry Heimberg
Research17 Nov 2013
Nature Biotechnology

Volume: 32, P: 76-83
Building an international consortium for tracking coronavirus health status

We call upon the research community to standardize efforts to use daily self-reported data about COVID-19 symptoms in the response to the pandemic and to form a collaborative consortium to maximize global gain while protecting participant privacy.

Eran Segal
Feng Zhang
Paul Wilmes
Comments & Opinion02 Jun 2020
Nature Medicine

Volume: 26, P: 1161-1165
Increased cyber-biosecurity for DNA synthesis

Rami Puzis
Dor Farbiash
Dov Greenbaum
Correspondence27 Nov 2020
Nature Biotechnology

Volume: 38, P: 1379-1381
A framework for identifying regional outbreak and spread of COVID-19 from one-minute population-wide surveys

Hagai Rossman
Ayya Keshet
Eran Segal
Correspondence09 Apr 2020
Nature Medicine

Volume: 26, P: 634-638
Gene expression analysis reveals a strong signature of an interferon-induced pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer

Uri Einav
Yuval Tabach
Eytan Domany
Research20 Jun 2005
Oncogene

Volume: 24, P: 6367-6375
Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

Pushkar Malakar
Lital Chartarifsky
Rotem Karni
ResearchOpen Access16 Aug 2016
Scientific Reports

Volume: 6, P: 1-14

Search

Atlas of imprinted and allele-specific DNA methylation in the human body

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

β-cell proliferation is the major source of new pancreatic β cells

Author Correction: ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

DNA-sensing inflammasomes cause recurrent atherosclerotic stroke

A DNA methylation atlas of normal human cell types

Megakaryocyte- and erythroblast-specific cell-free DNA patterns in plasma and platelets reflect thrombopoiesis and erythropoiesis levels

p16^Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells’ heterogeneity

The activating receptor NKp46 is essential for the development of type 1 diabetes

ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA

Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia

Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway

Author Correction: ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin

Publisher Correction: Building an international consortium for tracking coronavirus health status

Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Building an international consortium for tracking coronavirus health status

Increased cyber-biosecurity for DNA synthesis

A framework for identifying regional outbreak and spread of COVID-19 from one-minute population-wide surveys

Gene expression analysis reveals a strong signature of an interferon-induced pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer

Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

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