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Advanced filters: Author: Ze’ev Melamed Clear advanced filters

Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation

Stathmin-2 is lost in amyotrophic lateral sclerosis. Here the authors show that stathmin-2 has an essential role in the maintenance of axon structure, with its loss from adult motor neurons resulting in axonal collapse and muscle denervation.

Jone López-Erauskin
Mariana Bravo-Hernandez
Clotilde Lagier-Tourenne
Research23 Nov 2023
Nature Neuroscience

Volume: 27, P: 34-47
DNA methylation directs microRNA biogenesis in mammalian cells

Long primary transcripts of microRNAs are co-transcriptionally cleaved by the enzyme Drosha. Here the authors suggest that DNA methylation in miRNA loci in mammalian cells increases Drosha binding, slowing RNA polymerase II elongation to enhance miRNA biogenesis.

Ohad Glaich
Shivang Parikh
Carmit Levy
ResearchOpen Access11 Dec 2019
Nature Communications

Volume: 10, P: 1-11
Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

The mRNA encoding stathmin-2, a protein implicated in axonal growth, is shown to be widely suppressed by premature polyadenylation in both sporadic and C9orf72 ALS through a mechanism directly dependent on loss of nuclear TDP-43 in motor neurons.

Ze’ev Melamed
Jone López-Erauskin
Don W. Cleveland
Research14 Jan 2019
Nature Neuroscience

Volume: 22, P: 180-190