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An m⁶A methyltransferase confers host resistance by degrading viral proteins through ubiquitination

N⁶-methyladenosine and ubiquitination modifications play crucial roles in plant-virus interaction. Here, E3 ligase TaHAKAI is found to target the WYMV P2 for degradation and inhibit viral infection in wheat while increasing yield through m⁶A.

Jun Guo
Tianye Zhang
Jian Yang
ResearchOpen Access24 May 2025
Nature Communications

Volume: 16, P: 1-17

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An m6A methyltransferase confers host resistance by degrading viral proteins through ubiquitination

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An m⁶A methyltransferase confers host resistance by degrading viral proteins through ubiquitination