Downregulation of specific proteins named scramblases might enhance tumour immunosuppression. In this paper the authors first show that the scramblase Xrk8 is overexpressed in tumour cells upon treatment with chemotherapeutics, and then develop a nanomedicine platform for co-delivery of a cancer prodrug and an siRNA directed against the Xrk8 gene, showing therapeutic effect and enhanced immune response in animal tumour models.
- Yuang Chen
- Yixian Huang
- Song Li
