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Showing 1–50 of 64 results

Advanced filters: Author: Zhanjun Li Clear advanced filters

Inhibition of base editors with anti-deaminases derived from viruses

Anti-deaminases can inhibit APOBEC3, a component of cytosine base editors. Here Zhanjun Li and colleagues repurposed anti-deaminase proteins derived from viruses to inhibit base editors for use in efficient regulation of base editors’ activity in gene modification and therapeutic applications.

Zhiquan Liu
Siyu Chen
Zhanjun Li
ResearchOpen Access01 Feb 2022
Nature Communications

Volume: 13, P: 1-11
Author Correction: Unique progerin C-terminal peptide ameliorates Hutchinson–Gilford progeria syndrome phenotype by rescuing BUBR1

Na Zhang
Qianying Hu
Yu Zhang
Amendments and CorrectionsOpen Access02 May 2023
Nature Aging

Volume: 3, P: 752
Tumour extracellular vesicles and particles induce liver metabolic dysfunction

Remote tumours cause liver dysfunction by releasing extracellular vesicles and particles containing palmitic acid, which induces TNF signalling in Kupffer cells, resulting in inflammation, fatty deposits and metabolic dysregulation, thus both reducing the efficacy and increasing the toxicity of chemotherapies.

Gang Wang
Jianlong Li
David Lyden
Research24 May 2023
Nature

Volume: 618, P: 374-382
PCDHA9 as a candidate gene for amyotrophic lateral sclerosis

Genetic mutations are found in only 15% of sporadic ALS. Here, authors identify PCDHA9 as a candidate ALS gene and elucidate detailed underlying pathogenesis using mice with Pcdhα9 mutations that develop typical ALS phenotype and hallmark pathology.

Jie Zhong
Chaodong Wang
Zhiheng Xu
ResearchOpen Access11 Mar 2024
Nature Communications

Volume: 15, P: 1-22
mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1

Zhong, Wan and Cai et al. show that deficiency of the microsomal prostaglandin E synthase-2 (mPGES-2) in pancreatic β-cells improves glucose metabolism and insulin secretion in mice by inhibiting β-cell senescence and dysfunction during diabetes.

Dandan Zhong
Zhikang Wan
Ying Sun
Research28 Feb 2022
Nature Metabolism

Volume: 4, P: 269-283
Experimental confirmation of driving pressure boosting and smoothing for hybrid-drive inertial fusion at the 100-kJ laser facility

In laser-driven inertial fusion, finding optimal driving pressure is a major challenge. Here, the authors use a 100 kJ SG laser and a hybrid-drive scheme to demonstrate such driving pressure with the help of the direct-drive laser such that the indirect-drive radiation ablation pressure is turned into a well-smoothed hybrid-drive pressure much greater than the radiation ablation pressure.

Ji Yan
Jiwei Li
Shaoping Zhu
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-9
A strategy for Cas13 miniaturization based on the structure and AlphaFold

Small Cas enzymes are required for therapeutic use. Here the authors report an Interaction, Dynamics and Conservation (IDC) strategy for protein miniaturisation and use this to generate five compact variants of Cas13 based on a combination of IDC strategy and AlphaFold2.

Feiyu Zhao
Tao Zhang
Zhanjun Li
ResearchOpen Access08 Sept 2023
Nature Communications

Volume: 14, P: 1-13
PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition

Yating Sun
Dan Li
Wanhua Xie
ResearchOpen Access21 May 2022
Cell Death & Disease

Volume: 13, P: 1-14
Efficient and fast arsenate removal from water by in-situ formed magnesium hydroxide

Juanjuan Zhou
Ying Yang
Zhanjun Li
ResearchOpen Access11 Sept 2024
Scientific Reports

Volume: 14, P: 1-9
Leisure activities as reserve mediators of the relationship between loneliness and cognition in aging

Chao Du
Xin Li
Zhanjun Zhang
ResearchOpen Access28 May 2024
Translational Psychiatry

Volume: 14, P: 1-6
Influence of Different Media on Micromorphology of Radiation Synthesized Poly(acrylamide-sodium acrylate) Hydrogels

Jun Shan
Zhanjun Liu
Jie Chen
Research01 Jul 1998
Polymer Journal

Volume: 30, P: 585-588
RaGeoSense for smart home gesture recognition using sparse millimeter wave radar point clouds

Honghong Chen
Xiangyu Wang
Ben Xi
ResearchOpen Access01 May 2025
Scientific Reports

Volume: 15, P: 1-23
Unique progerin C-terminal peptide ameliorates Hutchinson–Gilford progeria syndrome phenotype by rescuing BUBR1

Zhang et al. demonstrate that targeting BUBR1, a nuclear mitotic spindle assembly checkpoint protein, alleviates premature aging phenotypes of progeria in mice via disrupting its nuclear mislocalization induced by progerin interaction.

Na Zhang
Qianying Hu
Yu Zhang
ResearchOpen Access02 Feb 2023
Nature Aging

Volume: 3, P: 185-201
Bubble-Film Network Structures of Radiation Synthesized Terpolymer Hydrogels

Jun Shan
Zhanjun Liu
Yanjun Zhang
Research01 Jul 1997
Polymer Journal

Volume: 29, P: 580-582
Polymerized small molecular acceptor based all-polymer solar cells with an efficiency of 16.16% via tuning polymer blend morphology by molecular design

Through development of non-fullerene acceptors, OPVs have reached efficiencies of 18%, yet the inadequate operational lifetime still poses a challenge for the commercialisation. Here, the authors investigate the origin of instability of NFA solar cells, and propose some strategies to mitigate this issue.

Jiaqi Du
Ke Hu
Yongfang Li
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-10
Ultra-fast charging in aluminum-ion batteries: electric double layers on active anode

Developing high-capacity batteries with high-rate performance has been a challenge. Here, the authors use a liquid metal alloy as anode in the aluminum-ion battery to push the boundaries, enabling the discovery of new roles of electric double layers in facilitating a high-rate charge transfer.

Xuejing Shen
Tao Sun
Li Tan
ResearchOpen Access05 Feb 2021
Nature Communications

Volume: 12, P: 1-12
Ultrathin metal–organic framework membrane production by gel–vapour deposition

MOF-based membranes have shown great promise in separation applications, but producing thin membranes that allow for high fluxes remains challenging. Here, the authors use a gel–vapour deposition strategy to fabricate composite membranes with less than 20 nm thicknesses and high gas permeances and selectivities.

Wanbin Li
Pengcheng Su
Eddy Zeng
ResearchOpen Access01 Sept 2017
Nature Communications

Volume: 8, P: 1-8
Efficient base editing with high precision in rabbits using YFE-BE4max

Zhiquan Liu
Siyu Chen
Zhanjun Li
ResearchOpen Access20 Jan 2020
Cell Death & Disease

Volume: 11, P: 1-11
Highly efficient RNA-guided base editing in rabbit

Base editors can make targeted changes without inducing a double-stranded break. Here, the authors apply the BE3 and ABE7.10 systems to rabbit to create highly efficient targeted base substitutions and various mutation types, and show reduced frequency of undesired by-products with the updated BE4-Gam system.

Zhiquan Liu
Mao Chen
Zhanjun Li
ResearchOpen Access13 Jul 2018
Nature Communications

Volume: 9, P: 1-10
Development of muscular dystrophy in a CRISPR-engineered mutant rabbit model with frame-disrupting ANO5 mutations

Tingting Sui
Li Xu
Zhanjun Li
ResearchOpen Access22 May 2018
Cell Death & Disease

Volume: 9, P: 1-10
The structure and function of the global citrus rhizosphere microbiome

Research on plant root-associated microbial communities may help develop more efficient or sustainable crop production methods. Here the authors analyse the citrus rhizosphere microbiome, using both amplicon and deep shotgun metagenomic sequencing of samples collected across six continents.

Jin Xu
Yunzeng Zhang
Nian Wang
ResearchOpen Access20 Nov 2018
Nature Communications

Volume: 9, P: 1-10
Self-Assembly of Graphene on Carbon Nanotube Surfaces

Kaiyuan Li
Gyula Eres
Zhengwei Pan
ResearchOpen Access05 Aug 2013
Scientific Reports

Volume: 3, P: 1-4
ULTRAWX: A ubiquitous realtime acoustic gesture information interaction system based on Tiou DODA

Zhenyi Zhang
Zhanjun Hao
Mengqiao Li
ResearchOpen Access20 Mar 2025
Scientific Reports

Volume: 15, P: 1-17
Antibiotics modulate neoadjuvant therapy efficiency in patients with breast cancer: a pilot analysis

Xi Zhang
Long Yu
Cuizhi Geng
ResearchOpen Access07 Jul 2021
Scientific Reports

Volume: 11, P: 1-7
Downregulation of histone methyltransferase SET8 inhibits progression of hepatocellular carcinoma

Jianhua Wu
Kuangyuan Qiao
Zhanjun Guo
ResearchOpen Access11 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
Celastrol attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3 inflammasome activation

Zhenzhen Sun
Yuanyuan Li
Zhanjun Jia
ResearchOpen Access05 Jul 2019
Cell Death Discovery

Volume: 5, P: 1-9
Efficient Generation of Myostatin Gene Mutated Rabbit by CRISPR/Cas9

Qingyan Lv
Lin Yuan
Liangxue Lai
ResearchOpen Access26 Apr 2016
Scientific Reports

Volume: 6, P: 1-8
CRISPR/Cas9-mediated mutation of tyrosinase (Tyr) 3′ UTR induce graying in rabbit

Yuning Song
Yuxin Xu
Zhanjun Li
ResearchOpen Access08 May 2017
Scientific Reports

Volume: 7, P: 1-8
CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts

Lin Yuan
Tingting Sui
Liangxue Lai
ResearchOpen Access25 Feb 2016
Scientific Reports

Volume: 6, P: 1-9
Transmission of Mouse Senile Amyloidosis

Yanming Xing
Akihiro Nakamura
Keiichi Higuchi
Research01 Apr 2001
Laboratory Investigation

Volume: 81, P: 493-499
Uncovering narrative aging: an underlying neural mechanism compensated through spatial constructional ability

A cross-validation based cognitive neuro-decoding framework uncovers the narrative aging and its neural characteristics which suggest a compensatory interaction associated with spatial-constructional ability.

Yumeng Li
Junying Zhang
Zhanjun Zhang
ResearchOpen Access21 Jan 2025
Communications Biology

Volume: 8, P: 1-15
Potential drug targets for tumors identified through Mendelian randomization analysis

Na Song
Pingyu Shi
Haijun Wang
ResearchOpen Access18 May 2024
Scientific Reports

Volume: 14, P: 1-9
Disorder-specific neurodynamic features in schizophrenia inferred by neurodynamic embedded contrastive variational autoencoder model

Chaoyue Ding
Yuqing Sun
Bing Liu
ResearchOpen Access18 Dec 2024
Translational Psychiatry

Volume: 14, P: 1-14
FMCW-based contactless heart rate monitoring

Zhanjun Hao
Yifei Gao
Fenfang Li
ResearchOpen Access21 Jan 2025
Scientific Reports

Volume: 15, P: 1-20
Millimeter wave gesture recognition using multi-feature fusion models in complex scenes

Zhanjun Hao
Zhizhou Sun
Jianxiang Peng
ResearchOpen Access14 Jun 2024
Scientific Reports

Volume: 14, P: 1-21
A new seven-axis robotic-assisted total hip arthroplasty system improves component positioning: a prospective, randomized, multicenter study

Run Tian
Xu Gao
Pei Yang
ResearchOpen Access02 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop

Sheng Yang
JiaJun Xie
Yang Zhang
ResearchOpen Access01 Mar 2024
Experimental & Molecular Medicine

Volume: 56, P: 630-645
Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

Carrie O’Connor
Adrianne Wallace-Povirk
Zhanjun Hou
ResearchOpen Access18 Mar 2021
Scientific Reports

Volume: 11, P: 1-14
Distinct chemokines selectively induce HIV-1 gp120-integrin α4β7 binding via triggering conformer-specific activation of α4β7

Shu Wang
ChangDong Lin
JianFeng Chen
ResearchOpen Access16 Jul 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-4
Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

Adrianne Wallace-Povirk
Lisa Rubinsak
Larry H. Matherly
ResearchOpen Access05 Jul 2022
Scientific Reports

Volume: 12, P: 1-15
Human umbilical cord mesenchymal stem cell transfusion in immune non-responders with AIDS: a multicenter randomized controlled trial

Lifeng Wang
Zheng Zhang
Fu-Sheng Wang
ResearchOpen Access09 Jun 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-8
Correction: Development of muscular dystrophy in a CRISPR-engineered mutant rabbit model with frame-disrupting ANO5 mutations

Tingting Sui
Li Xu
Zhanjun Li
Amendments and CorrectionsOpen Access17 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-2
Erratum: Sex Moderates the Effects of the Sorl1 Gene rs2070045 Polymorphism on Cognitive Impairment and Disruption of the Cingulum Integrity in Healthy Elderly

Ying Liang
He Li
Zhanjun Zhang
Amendments and Corrections13 Apr 2015
Neuropsychopharmacology

Volume: 40, P: 2487
The MiR-135b–BMAL1–YY1 loop disturbs pancreatic clockwork to promote tumourigenesis and chemoresistance

Weiliang Jiang
Senlin Zhao
Rong Wan
ResearchOpen Access02 Feb 2018
Cell Death & Disease

Volume: 9, P: 1-15
Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Weiwei Xia
Yuanyuan Li
Zhanjun Jia
ResearchOpen Access01 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-15
Correction: Corrigendum: A Two-Year Treatment of Amnestic Mild Cognitive Impairment using a Compound Chinese Medicine: A Placebo Controlled Randomized Trial

Junying Zhang
Zhen Liu
Zhanjun Zhang
Amendments and CorrectionsOpen Access19 Aug 2016
Scientific Reports

Volume: 6, P: 1
The positive effects of Xueshuan Xinmai tablets on brain functional connectivity in acute ischemic stroke: a placebo controlled randomized trial

Dongfeng Wei
Daojun Xie
Zhanjun Zhang
ResearchOpen Access10 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Optimization of a CRISPR/Cas9-mediated Knock-in Strategy at the Porcine Rosa26 Locus in Porcine Foetal Fibroblasts

Zicong Xie
Daxin Pang
Xiaochun Tang
ResearchOpen Access08 Jun 2017
Scientific Reports

Volume: 7, P: 1-12
High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m⁶A demethylation: a potential mechanism for diabetic cognitive dysfunction

Minli Qu
Linhui Zuo
Jing Wu
ResearchOpen Access29 Jun 2023
Cell Death & Disease

Volume: 14, P: 1-15
Versatile and efficient genome editing with Neisseria cinerea Cas9

A Neisseria cinerea Cas9 variant is characterised in PAM preference, editing efficiency (for both nuclease and base editing) and anti-CRISPR protein blocking, with a PAM of (N)4GYAT reported alongside a mouse zygote assay.

Zhiquan Liu
Siyu Chen
Zhanjun Li
ResearchOpen Access26 Nov 2022
Communications Biology

Volume: 5, P: 1-7

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