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Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

How to achieve ideal antiferroelectricity with sharp switching in nanoscale thin films remains challenges. The authors here unveil the selective stepwise transition, achieve ideal antiferroelectricity with large digital electrostrain in PbZrO₃ epitaxial thin films.

Integrating the Pancharatnam–Berry phase with integrated resonant nanoantennas in a metalens design produces an achromatic device capable of full-colour imaging in the visible range in transmission mode.

The tumour microenvironment features influencing response to neoadjuvant immunochemotherapy (nICT) in esophageal squamous cell carcinoma (ESCC) remain to be explored. Here, single cell and TCR sequencing on pre- and post- nICT treatment ESCC tissues identifies the presence of CXCL13⁺CD8⁺ T cells as a predictor of improved response and the enrichment of TNFRSF4⁺CD4⁺ Tregs as a marker of treatment resistance.

Now a generalizable method that couples spatially directed tagging with condensation-enhanced crosslinking—termed DenseMAP—has been developed for profiling the spatiotemporal protein interactome within biomolecular condensates. By linking the information between protein interactions and subcellular locations, DenseMAP has uncovered regulatory mechanisms in subcellular and subcompartmental condensates.

A metalens array of GaN nanoantennas is used to make a full-colour achromatic light-field camera.

A strategy of on-device phase engineering of two-dimensional materials is proposed, allowing the in situ realization of various lattice phases with distinct stoichiometries and versatile functions.

No method exists for real-time evaluation of the status of spinal implants. Here, the authors developed a bio-adhesive metal detector array (BioMDA) that provides a wearable, non-invasive solution for positional analyses of osseous implants within the spine.

The fully human single-___domain antibody n425 aginst NiV targets a conserved cryptic epitope on G protein and inhibits membrane fusion by disrupting tetramerization. These insights advance neutralization mechanisms and effective countermeasure design.

Liu et al. developed AI-driven, wearable olfactory interfaces with odor generators for realizing latency-free mixed-reality and fast olfaction recovery. This technology enables personalized olfactory feedback and enhanced virtual environments for various applications including education, and clinical treatment.

Incorporation of a ‘liquid diode’ into a wearable electronic platform enhances comfort and stability by shunting away sweat as it accumulates.

The SARS-CoV-2 pandemic highlighted our need for methods that allow rapid viral surveillance. Here, authors report a wireless, battery-free and wearable self-diagnosis platform that can continuously capture viral particles, diagnose infection status and evaluate symptom severity via breath and blow.

Inflammatory conditions often affect colorectal cancer patients, and their effect on their ongoing treatment is a pressing medical question. Here authors show that inflammation interferes with local anti-tumour immune response and inhibits response to immune checkpoint blockade therapy via immunosuppressive neutrophil leukocytes.

The majority of polar structures emerging naturally in ferroelectrics are topologically trivial. Here, the authors demonstrate reconstruction of topologically trivial strip-like ___domain architecture into arrays of polar vortex in (PbTiO₃)₁₀/(SrTiO₃)₁₀ superlattice.

A haptic interface that uses thermal, mechanical and electrotactile modes of stimulation to target different receptors in the skin can provide users with diverse haptic sensations, reproducing the tactile information of fine roughness, macro roughness, slipperiness, force and temperature.

Jumonji ___domain-containing histone demethylases regulate flowering in plants. Here Zheng et al. show that Arabidopsis JMJ13 is an H3K27me3 demethylase that recognizes H3K27me3 via hydrogen bonding and hydrophobic interactions and affects both photoperiod and temperature-dependent flowering responses.

Current approaches to distinguish topological phases from topologically-trivial phases have limited general applicability. Here, in a photonic-crystal context, the authors demonstrate that in trivial structures the bulk local density of states (LDOS) extends all the way to the edges and corners, while in topological structures the bulk LDOS actually avoids the edges and corners.

Miscanthus is widely used as a feedstock for cellulosic biofuel production. Genome sequencing shows that M. floridulus is most distantly related to other Miscanthus species and is more genetically diverse.

Antibodies targeting sclerostin can ameliorate postmenopausal osteoporosis but present some cardiovascular risk. Here the authors show that the cardiovascular and skeletal effects of sclerostin are mediated by different loops, suggesting ways to preserve the positive effects on bone formation while avoiding the negative cardiovascular consequences.

Prrx1-expressing can act as stem cells for bone, white adipose tissue and dermis in adult mice. These cells have a key role in tissue homeostasis and repair and are regulated by Wnt signaling.

Ferroelastic switching in thin films is typically restricted by constraints from the substrate or occurs around twin-like domains. Here, the authors show reversible and non-volatile ferroelastic switching avoiding substrate constraints in layered-perovskite Bi_2WO_6 epitaxial films.

EBS, which prevents premature flowering in Arabidopsis, is shown to bind H3K27me3 and H3K4me3 via different domains. Disruption of either EBS–H3K27me3 or EBS–H3K4me3 interaction induces early floral transition.

The quantum spin Hall effect is limited to one-dimensional lower boundary states which limits the possibilities for its exploitation in photonic devices. Here, the authors demonstrate a higher-order quantum spin Hall effect in a photonic crystal and observe opposite pseudospin corner states.

Histone mark reader proteins bind to particular histone modifications and regulate chromatin state. Here, Qian et al. show that the SHORT LIFE reader has a unique ability to recognize both activating and repressive histone marks and that these interactions enable SHORT LIFE to repress flowering in plants.

Wang et al. show that Akt methylation by SETDB1 is recognized by demethylase JMJD2A, which then recruits E3 ligases to induce K63-linked Akt ubiquitination, leading to Akt activation and tumorigenesis.

Liang and colleagues establish a high-quality protein expression resource for 8,000 The Cancer Genome Atlas patient samples and 900 Cancer Cell Line Encyclopedia cell lines for approximately 450 proteins, which they use to identify synthetic lethality pairs and metastasis markers.

Ning Li and colleagues report the whole-genome sequence of the duck, Anas platyrhynchos, a natural host of avian influenza viruses. They examine host response to infection by comparing the lung transcriptomes of ducks that were infected with influenza A viruses.

This paper describes molecular subtypes of cervical cancers, including squamous cell carcinoma and adenocarcinoma clusters defined by HPV status and molecular features, and distinct molecular pathways that are activated in cervical carcinomas caused by different somatic alterations and HPV types.

Loss of mismatch-repair protein ARID1A in cancer correlates with high mutation load & checkpoint blockade response, complementing MSI-based prognosis.

Moiré engineering has rapidly gained currency as a means to manipulate electronic states of matter in van der Waals heterostructures. Now, the feat is achieved in epitaxially grown oxide heterostructures, thus opening up fresh opportunities for strongly correlated electronic systems.

An integrative genomic analysis of several hundred endometrial carcinomas shows that a minority of tumour samples carry copy number alterations or TP53 mutations and many contain key cancer-related gene mutations, such as those involved in canonical pathways and chromatin remodelling; a reclassification of endometrial tumours into four distinct types is proposed, which may have an effect on patient treatment regimes.

In an experiment across China to test integrated soil–crop system management for rice, wheat and maize against current practice, improvements in grain yield are equivalent to high-input techniques, but nutrient use, nutrient loss and greenhouse gas emissions are lower than current practice.