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Conventional electrochemical evaluations severely decelerate the iteration of long-life batteries. Here, the authors unpuzzle the myth of coulombic loss contrary to prevailing understanding. Physical-correlated coulombic-capacity relation is pivotal for rapid battery screening and prognostics.

Stem cell therapies face immune rejection risks with allogeneic ESCs. Here, the authors establish genetically matched autologous ESCs in monkeys via embryo splitting, showing potentially superior genomic stability over iPSCs and ntESCs.

The injection of straw into subsoils can increase soil organic carbon and crop yields substantially and could therefore provide an effective approach for subsoil management in croplands, according to 15 years of field experiments on rice–wheat croplands in China.

Native crystallographic defects are often introduced during synthesis of battery materials, but has been overlooked. Here, using in situ synchrotron X-ray probes and electron microscopy, the authors have revealed their adverse effect during battery operation.

To push the boundary of sol-gel chemistry towards high quality organic membrane construction is challenging. Here, the authors show a controlled nanocrystal suturing strategy in sol-gel solutions to afford highly crystalline and free-standing covalent organic framework membranes.

Zhang and colleagues characterize a subset of nerve-associated CX3CR1⁺ liver portal area macrophages that maintain immune homeostasis and attenuate nonalcoholic steatohepatitis.

The sensitivity of Li-ion battery materials to moisture complicates their synthesis, storage, processing and recycling. Here, authors show that protonation causes structural instability in LiNi_xCo_yMn_1-x-yO₂ (0 <x,y < 1) and that controlled H⁺ and Li⁺ concentration in aqueous processing is critical.

Fluorides have been identified as a key ingredient in interphases supporting aggressive battery chemistries. Here, the authors show a positive charged organic cation carrying fluorine populates at the inner Helmholtz layer of the electrode and contributes to the interphasial chemistry.

The molecular mechanisms of astroblastoma development are identified, whereby distinct gene fusions upregulate shared transcriptional networks to disrupt the normal development of ventral telencephalon neural progenitors, which leads to oncogenesis.

Overcoming the suppressive tumor microenvironment (TME) is crucial to improving the efficacy of cancer therapy. Here the authors show that, in mouse cancer models, administration of exogenous IL-16 establishes a Th1-dominant TME via regulation of glutamine catabolism and triggers a Th1 cell-macrophage crosstalk, enhancing anti-tumor immune responses and the efficacy of immunotherapy.

Bullous pemphigoid (BP) is a type 2 immunity associated skin inflammatory disease. Here the authors characterize the underlying immune-stromal crosstalk in this disease using scRNA sequencing to show that IL13-IL13RA1 signals are involved with fibroblast and DC mediated enhancement of Th2 responses.

The global regulator PhoP plays crucial roles in bacterial pathogenicity. Shi et al. report four cryo-EM structures of PhoP-dependent transcription activation and repression complexes, revealing dual transcription regulation mechanisms of PhoP.

This study provides structural and biochemical insight into how mammalian PIWI proteins use a limited supply of piRNAs to silence a vast array of ever-evolving transposons in the germline.

Layered Ni-rich oxide cathodes are susceptible to challenges with surface reconstruction and strain propagation, limiting their cyclability. The authors propose a solution involving oriented attachment-driven reactions, utilizing Wadsley–Roth nanocrystals and layered oxide to induce an epitaxial entropy-assisted coating, effectively addressing these issues.

Metal oxides with a tunnelled structure are attractive as charge storage materials for rechargeable batteries and supercapacitors. Here, the authors investigate the role of tunnel cations in governing and enhancing the electrochemical properties of electrode materials.

This paper shows that nano-enabled dehydrogenation catalysis in biological systems induces a domino effect, including reductive stress, immunosuppression and tumour metastasis.

Iron-based nanozymes are promising for tumor catalytic therapy owing to their biocompatibility and peroxidase-like activity, but the concurrent catalase-like activity undermines the therapeutic efficacy. Here, the authors address this issue by developing a hemin–cysteine–Fe nanozyme, which exhibits catalytic selectivity and exclusive peroxidase-like activity.

The analysis of behavioural patterns from standardized video recordings of infants with varying degrees of visual impairment enables, via deep learning, classification of the infants by visual-impairment severity and by ophthalmological condition.

In situ synchrotron X-ray tools are used to perform microstrain screening during solid-state synthesis of battery materials, leading to fewer structural defects and improved performance.

Incorporating fluorine into battery components can improve the energy density, safety and cycling stability of rechargeable batteries. This Review explores the broad use of fluorinated compounds in battery design, examines the relationship between their chemical structure and battery performance and discusses the challenges and opportunities of fluorinated batteries within the present regulatory framework.

In Saccharomyces cerevisiae, the left arm of chromosome XII only requires 12 genes to maintain cell viability, whereas 25 genes are needed for robust fitness. Here the authors demonstrate that the entire arm can be replaced by a neochromosome with completely artificial sequences.

A reaction network executing a cascaded transient formation and depletion of three different catalytic strands is introduced. The system is coupled to the secondary temporal synthesis of different coded strands as gene models.

Previous studies have shown genetic associations between leprosy and 18 different genes/loci. Here, Wang and colleagues perform genome-wide association study in Han Chinese leprosy patients and describe four novel loci to be associated to the disease.

The routes and lengths of migrations of Eurasian Arctic peregrine falcons have probably been shaped by climate change across the Last Glacial Maximum–Holocene transition and by selection for long-term memory acting on ADCY8, respectively.

Capturing the detailed structural evolution of electronic excited states is a challenging but critical step to understand and control ultrafast molecular dynamics. Here, combining a Coulomb explosion imaging approach and molecular dynamics simulations, the authors retrieve the transient geometry of the ground and excited states of D2O mono- and dication with few femtosecond, few picometre accuracy.

The application of dietary methionine intervention is of particular interest in the field of cancer therapy. Here the authors show that intermittent but not sustained deprivation of methionine promotes tumor ferroptosis and improves response to checkpoint inhibitors.

A smartphone-based system, designed to induce a steady gaze in children using cartoon-like video stimuli, can identify visually impaired children across a wide range of ophthalmic disorders, based on analysis of gazing behaviors and facial features.

TREE1 and its homologue DAZ3 are expressed exclusively in Arabidopsis sperm, showing how genetic deficiencies can exert enduring paternal effects on specific plant organ differentiation and how parental-of-origin genes interact to ensure normal embryogenesis.

Here the authors report a crystal structure of a pseudoknot-containing hammerhead ribozyme. Catalysis is based upon a general base (G N1) and a general acid (G O2’). The structure is closely similar to the pistol ribozyme, but mechanistically different.

HRG-9 (also known as TANGO2) is an evolutionarily conserved haem chaperone that traffics haem from sites of storage or synthesis in eukaryotic cells.

Uncovering the mechanism behind neutral H₂ formation from ionised hydrocarbon molecules still poses severe challenges. Here, based on the orbital fingerprints in the photoelectron momentum distributions, the authors were able to resolve the contributions of the ground and excited ionic states to the H₂ formation channel.

Self-sufficient cytochrome P450 monooxygenases, which contain all redox partners in a single polypeptide chain, are of interest for biotechnological applications. Here, the authors present the crystal structure of full-length Thermobispora bispora CYP116B46 and discuss the potential electron transfer pathway.

Diterpene synthase VenA catalyses the synthesis of venezuelaene A with a unique 5-5-6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. Here, the authors report crystal structures of apo- and holo-VenA, provide mechanistic insights into its substrate selectivity and promiscuity, and engineer VenA into a sesterterpene synthase.

Incomplete denitrification associated with the micro-niche of marine particles, instead of nitrification as previously assumed, is a major source of N₂O in the turbid coastal waters, even though the water is well-oxygenated.

An inhalable virus-like-particle consisting of exosomes decorated with a recombinant SARS-CoV-2 receptor-binding ___domain is stable at room temperature and elicits systemic and mucosal immune responses in small animals.

Mikania micrantha is an extremely fast-growing invasive plant species that can cause serious damage to natural ecosystems. Here, the authors assemble its chromosome-scale reference genome and explore possible mechanisms that contribute to its rapid growth.