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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model

Julin Wang
Tianyu Miao
Jichun Zhao
ResearchOpen Access29 May 2025
Scientific Reports

Volume: 15, P: 1-12
Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window

Stimuli-responsive nanomaterials offer the opportunity to exploit nanoscale cooperativity to improve the precision of diagnostic or therapeutic outcomes. Here, the authors report the design, synthesis and characterization of a series of degradable ultra-pH sensitive polymers that amplify small acidic pH changes to efficacious therapeutic outputs.

Xu Wang
Jonathan Wilhelm
Jinming Gao
ResearchOpen Access17 Nov 2020
Nature Communications

Volume: 11, P: 1-12
Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance

Despite the presence of tumor-infiltrating lymphocytes, many patients do not respond to PD-L1/PD-1 blockade therapy. Here they show that PD-L1 antibody armed with interferon-α (IFNα) improves tumor targeting and antigen presentation while countering innate or T-cell-drive PD-L1 upregulation, and overcomes resistance to checkpoint blockade therapy.

Yong Liang
Haidong Tang
Yang-Xin Fu
ResearchOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1-11
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Zhiming Cai and colleagues report the exome sequencing of tumor and matched normal tissue from nine transitional cell carcinomas (TCCs) of the bladder, with further screening in 88 additional subjects. The authors identify mutations in chromatin remodeling genes in 59% of the 97 TCC subjects.

Yaoting Gui
Guangwu Guo
Zhiming Cai
Research07 Aug 2011
Nature Genetics

Volume: 43, P: 875-878
Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model

Huanyao Liu
Shanshan Huang
Weiqiang Li
ResearchOpen Access05 Dec 2022
Cell Death & Disease

Volume: 13, P: 1-12
A highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice

Ling Zhang
Xi Emily Zheng
Jing Zhao
ResearchOpen Access08 Jan 2016
Scientific Reports

Volume: 6, P: 1-10

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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model

Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window

Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model

A highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice

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