Nature Search

Inorganic perovskite/organic tandem solar cells with 25.1% certified efficiency via bottom contact modulation

The performance of inorganic, wide-bandgap perovskite solar cells is hindered by unsuitable electron transport layers. Han et al. design an acidic magnesium-doped tin oxide quantum dot layer, improving efficiency and stability in single-junction and tandem cells.

Yu Han
Jiehao Fu
Gang Li
Research13 Mar 2025
Nature Energy

Volume: 10, P: 513-525
Correction: Corrigendum: RNA m⁶A methylation regulates the ultraviolet-induced DNA damage response

Yang Xiang
Benoit Laurent
Yang Shi
Amendments and Corrections29 Nov 2017
Nature

Volume: 552, P: 430
Correction: Corrigendum: Structural basis for selective binding of m⁶A RNA by the YTHDC1 YTH ___domain

Chao Xu
Xiao Wang
Jinrong Min
Amendments and Corrections17 Sept 2015
Nature Chemical Biology

Volume: 11, P: 815
PEAC-seq adopts Prime Editor to detect CRISPR off-target and DNA translocation

It is still a challenge to accurately identify off-target endonuclease edits. Here the authors report PEAC-seq using a Prime Editor to insert a tag to the editing sites and enrich the tagged regions with site-specific primers for sequencing: they show that PEAC-seq could identify DNA translocations.

Zhenxing Yu
Zhike Lu
Lijia Ma
ResearchOpen Access12 Dec 2022
Nature Communications

Volume: 13, P: 1-13
Publisher Correction: N⁶-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

Honghui Ma
Xiaoyun Wang
Chuan He
Amendments and Corrections08 Feb 2019
Nature Chemical Biology

Volume: 15, P: 549
Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA

A genome-wide uracil profiling technology (termed “dU-seq”), based on selective labeling and biotin pull-down, reveals that uracil is enriched at the centromere of the human genome.

Xiaoting Shu
Menghao Liu
Chengqi Yi
Research21 May 2018
Nature Chemical Biology

Volume: 14, P: 680-687
PhyloVelo enhances transcriptomic velocity field mapping using monotonically expressed genes

A refined velocity model improves cell fate mapping with lineage-traced scRNA-seq data.

Kun Wang
Liangzhen Hou
Zheng Hu
Research31 Jul 2023
Nature Biotechnology

Volume: 42, P: 778-789
Structural basis for selective binding of m⁶A RNA by the YTHDC1 YTH ___domain

N⁶-methyladenosine (m⁶A) is an abundant eukaryotic RNA modification that regulates mRNA stability. Biochemical analysis and crystallographic visualization of m⁶A-YTHDC1 interactions establish this YTH family member as an m⁶A reader and explain its RNA consensus sequence selectivity.

Chao Xu
Xiao Wang
Jinrong Min
Research21 Sept 2014
Nature Chemical Biology

Volume: 10, P: 927-929
Viral N⁶-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

Here, Xue et al. identify N⁶-methyladenosine (m⁶A) modification sites in RNAs of respiratory syncytial virus (RSV) and show that these sites, particularly sites in the transcript encoding for the viral glycoprotein, affect virus replication in primary human cells and cotton rats.

Miaoge Xue
Boxuan Simen Zhao
Jianrong Li
ResearchOpen Access09 Oct 2019
Nature Communications

Volume: 10, P: 1-18
m⁶A facilitates hippocampus-dependent learning and memory through YTHDF1

Neuronal stimulation induces protein translation of m⁶A-methylated neuronal mRNAs facilitated by YTHDF1, and this process contributes to learning and memory.

Hailing Shi
Xuliang Zhang
Tao Zhou
Research31 Oct 2018
Nature

Volume: 563, P: 249-253
The diploid genome sequence of an Asian individual

Jun Wang
Wei Wang
Jian Wang
ResearchOpen Access06 Nov 2008
Nature

Volume: 456, P: 60-65
N⁶-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

ZCCHC4 was identified as a mammalian ribosome RNA (rRNA) N⁶-methyladenosine (m⁶A) writer protein that installs m⁶A 4220 in 28S rRNA. 28S rRNA methylation affects global translation and cell growth and contributes to tumorigenesis in cancer cells.

Honghui Ma
Xiaoyun Wang
Chuan He
Research10 Dec 2018
Nature Chemical Biology

Volume: 15, P: 88-94
A metabolic labeling method detects m⁶A transcriptome-wide at single base resolution

The authors developed a metabolic labeling method via incorporation of allyl-SAM analogs to profile transcriptome-wide m⁶A at base resolution, which enables identification of m⁶A motifs and clustered m⁶A sites.

Xiao Shu
Jie Cao
Jianzhao Liu
Research27 Apr 2020
Nature Chemical Biology

Volume: 16, P: 887-895
m⁶A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

FTO is an m6A demethylase. Here, the authors show that FTO promotes melanoma tumorigenicity and contributes to resistance to anti-PD1 blockade, while FTO inhibition sensitizes melanoma to anti-PD1 blockade.

Seungwon Yang
Jiangbo Wei
Yu-Ying He
ResearchOpen Access25 Jun 2019
Nature Communications

Volume: 10, P: 1-14
Unique features of the m⁶A methylome in Arabidopsis thaliana

Modification of mRNA with N⁶-methyladenosine (m6A) is proposed to regulate transcript stability. Here, Jia et al. uncover plant-specific features in the m6A methylome of Arabidopsis, such as methylation enrichment around the start codon, and suggest a positive role in gene expression.

Guan-Zheng Luo
Alice MacQueen
Chuan He
Research28 Nov 2014
Nature Communications

Volume: 5, P: 1-8
m⁶A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

Liu et al. show that reduced m⁶A mRNA methylation in endometrial cancer is oncogenic. Mechanistically, the AKT pathway is activated in these tumours due to altered expression of AKT regulators carrying m⁶A on their transcripts.

Jun Liu
Mark A. Eckert
Chuan He
Research27 Aug 2018
Nature Cell Biology

Volume: 20, P: 1074-1083
Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark

Histone post-translational modifications are important regulators of chromatin structure and gene expression. Lysine 2-hydroxisobutyrylation sites, discovered by MS and validated by chemical synthesis, are found in active chromatin and associated with male germ cell differentiation.

Lunzhi Dai
Chao Peng
Yingming Zhao
Research30 Mar 2014
Nature Chemical Biology

Volume: 10, P: 365-370
Histone H3 trimethylation at lysine 36 guides m⁶A RNA modification co-transcriptionally

METTL14 recognizes the trimethyl mark on lysine 36 of histone H3 that directs m⁶A modifications co-transcriptionally.

Huilin Huang
Hengyou Weng
Jianjun Chen
Research13 Mar 2019
Nature

Volume: 567, P: 414-419
Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities

Heng Zhang
Jianfeng Yan
Lijia Ma
ResearchOpen Access16 May 2023
Cell Discovery

Volume: 9, P: 1-20
Inferring causal molecular networks: empirical assessment through a community-based effort

The HPN-DREAM community challenge assessed the ability of computational methods to infer causal molecular networks, focusing specifically on the task of inferring causal protein signaling networks in cancer cell lines.

Steven M Hill
Laura M Heiser
Sach Mukherjee
ResearchOpen Access22 Feb 2016
Nature Methods

Volume: 13, P: 310-318
A METTL3–METTL14 complex mediates mammalian nuclear RNA N⁶-adenosine methylation

Certain adenosine residues within mammalian RNAs undergo reversible N6 methylation. Two methyltransferase enzymes, METTL3 and METTL14, as well as the splicing factor WTAP are identified as core components of the multiprotein complex that deposits RNA N⁶-methyladenosine (m⁶A) in nuclear RNAs.

Jianzhao Liu
Yanan Yue
Chuan He
Research06 Dec 2013
Nature Chemical Biology

Volume: 10, P: 93-95
RNA m⁶A methylation regulates the ultraviolet-induced DNA damage response

Methylation at the 6 position of adenosine (m⁶A) in RNA is rapidly and transiently induced at DNA damage sites in response to ultraviolet irradiation.

Yang Xiang
Benoit Laurent
Yang Shi
Research15 Mar 2017
Nature

Volume: 543, P: 573-576
m⁶A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

The N⁶-methyladenosine (m⁶A) modification facilitates maternally driven clearance of zebrafish maternal mRNAs through the m⁶A-binding protein Ythdf2, ensuring proper and timely embryonic development.

Boxuan Simen Zhao
Xiao Wang
Chuan He
Research13 Feb 2017
Nature

Volume: 542, P: 475-478
N⁶-methyladenosine-dependent regulation of messenger RNA stability

The mRNAs of higher eukaryotes are extensively modified internally with N⁶-methyladenosine, but the specific functional role of this modification has been unclear; here this modification on mRNA is shown to be recognized by several proteins, the modification and its recognition serve to regulate the RNA’s lifetime.

Xiao Wang
Zhike Lu
Chuan He
Research27 Nov 2013
Nature

Volume: 505, P: 117-120
The RNA m⁶A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression

Yang Liu
Renjie Song
Xuetao Cao
ResearchOpen Access20 Dec 2023
Cellular & Molecular Immunology

Volume: 21, P: 6-18
Author Correction: Optimized minimal genome-wide human sgRNA library

Yangfan Zhou
Lixia Wang
Lijia Ma
Amendments and CorrectionsOpen Access16 Aug 2023
Scientific Reports

Volume: 13, P: 1
N⁶-methyladenosine (m⁶A) recruits and repels proteins to regulate mRNA homeostasis

A comprehensive proteomics screen for ‘reader’ proteins that recognize m⁶A-modified RNA reveals that the modification both promotes and prevents the binding of factors that control mRNA homeostasis in mammalian cells.

Raghu R Edupuganti
Simon Geiger
Michiel Vermeulen
Research04 Sept 2017
Nature Structural & Molecular Biology

Volume: 24, P: 870-878
m⁶A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration

Yang Liu
Renjie Song
Xuetao Cao
ResearchOpen Access29 Jun 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-15
Optimized minimal genome-wide human sgRNA library

Yangfan Zhou
Lixia Wang
Lijia Ma
ResearchOpen Access18 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
Mettl3-/Mettl14-mediated mRNA N⁶-methyladenosine modulates murine spermatogenesis

Zhen Lin
Phillip J Hsu
Ming-Han Tong
Research15 Sept 2017
Cell Research

Volume: 27, P: 1216-1230
Ythdc2 is an N⁶-methyladenosine binding protein that regulates mammalian spermatogenesis

Phillip J Hsu
Yunfei Zhu
Chuan He
Research15 Aug 2017
Cell Research

Volume: 27, P: 1115-1127
YTHDF3 facilitates translation and decay of N⁶-methyladenosine-modified RNA

Hailing Shi
Xiao Wang
Chuan He
Research20 Jan 2017
Cell Research

Volume: 27, P: 315-328

Search

Inorganic perovskite/organic tandem solar cells with 25.1% certified efficiency via bottom contact modulation

Correction: Corrigendum: RNA m⁶A methylation regulates the ultraviolet-induced DNA damage response

Correction: Corrigendum: Structural basis for selective binding of m⁶A RNA by the YTHDC1 YTH ___domain

PEAC-seq adopts Prime Editor to detect CRISPR off-target and DNA translocation

Publisher Correction: N⁶-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA

PhyloVelo enhances transcriptomic velocity field mapping using monotonically expressed genes

Structural basis for selective binding of m⁶A RNA by the YTHDC1 YTH ___domain

Viral N⁶-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

m⁶A facilitates hippocampus-dependent learning and memory through YTHDF1

The diploid genome sequence of an Asian individual

N⁶-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

A metabolic labeling method detects m⁶A transcriptome-wide at single base resolution

m⁶A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

Unique features of the m⁶A methylome in Arabidopsis thaliana

m⁶A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark

Histone H3 trimethylation at lysine 36 guides m⁶A RNA modification co-transcriptionally

Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities

Inferring causal molecular networks: empirical assessment through a community-based effort

A METTL3–METTL14 complex mediates mammalian nuclear RNA N⁶-adenosine methylation

RNA m⁶A methylation regulates the ultraviolet-induced DNA damage response

m⁶A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

N⁶-methyladenosine-dependent regulation of messenger RNA stability

The RNA m⁶A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression

Author Correction: Optimized minimal genome-wide human sgRNA library

N⁶-methyladenosine (m⁶A) recruits and repels proteins to regulate mRNA homeostasis

m⁶A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration

Optimized minimal genome-wide human sgRNA library

Mettl3-/Mettl14-mediated mRNA N⁶-methyladenosine modulates murine spermatogenesis

Ythdc2 is an N⁶-methyladenosine binding protein that regulates mammalian spermatogenesis

YTHDF3 facilitates translation and decay of N⁶-methyladenosine-modified RNA

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