Nature Search

Profiling of hMPV F-specific antibodies isolated from human memory B cells

Here, Xiao et al. isolate a large panel of antibodies against human metapneumovirus fusion protein from human B cells, and characterize their epitopes, neutralization activities, and antigen binding specificity, providing a useful framework for understanding the immune response against hMPV.

Xiao Xiao
Arthur Fridman
Lan Zhang
ResearchOpen Access10 May 2022
Nature Communications

Volume: 13, P: 1-13
APOE–NOTCH axis governs elastogenesis during human cardiac valve remodeling

Z. Liu, Y. Liu and Z. Yu et al. discovered a subtype of valve interstitial cells underneath the valve endothelial cells sensing unidirectional flow. These cells express high levels of APOE, which is responsible for JAG1–NOTCH2-mediated fetal elastogenesis.

Ziyi Liu
Yu Liu
Mingxia Gu
Research24 Jul 2024
Nature Cardiovascular Research

Volume: 3, P: 933-950
Low-dose metformin targets the lysosomal AMPK pathway through PEN2

The molecular target of the antidiabetic medicine metformin is identified as PEN2, a subunit of γ-secretases, and the PEN2–ATP6AP1 axis offers potential targets for screening for metformin substitutes.

Teng Ma
Xiao Tian
Sheng-Cai Lin
ResearchOpen Access23 Feb 2022
Nature

Volume: 603, P: 159-165
A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein

Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization. Here, the authors isolate a human monoclonal antibody that binds to a highly conserved epitope on the RSV fusion protein, neutralizes RSV A and B subtypes equipotently and is protective in the cotton rat model.

Aimin Tang
Zhifeng Chen
Kalpit A. Vora
ResearchOpen Access12 Sept 2019
Nature Communications

Volume: 10, P: 1-13
Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection

Amy S. Espeseth
Pedro J. Cejas
Andrew J. Bett
ResearchOpen Access14 Feb 2020
npj Vaccines

Volume: 5, P: 1-14
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis

Bin Zhang
Jie Li
Kunyu Yang
ResearchOpen Access29 Jan 2024
Cell Death & Differentiation

Volume: 31, P: 309-321
Activation of β₂-adrenergic receptors prevents AD-type synaptotoxicity via epigenetic mechanisms

Ming Jin
Zhiyun Wei
Shaomin Li
Research26 Jun 2023
Molecular Psychiatry

Volume: 28, P: 4877-4888
Discovery and multimerization of cross-reactive single-___domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants

Scott A. Hollingsworth
Cameron L. Noland
Kalyan Pande
ResearchOpen Access22 Aug 2023
Scientific Reports

Volume: 13, P: 1-15
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress

Yue Zong
Chen-Song Zhang
Sheng-Cai Lin
Research04 Apr 2019
Cell Research

Volume: 29, P: 460-473
Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease

Yunlong Zhang
Xiaoliang He
Shaogang Qu
ResearchOpen Access09 Feb 2017
Cell Death & Disease

Volume: 8, P: e2611

Search

Filter By:

Search

Quick links