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A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Pei et al. overcome desorption of passivating molecules under photothermal stress in wide-bandgap perovskites and achieve perovskite/Cu(In,Ga)Se₂ tandem solar cells with a certified efficiency of 27.35%.

Sweat sensors are important in personalized healthcare using natural oxidase to target biomolecules but these reactions are susceptible to external interference. Here, the authors report tryptophan- and histidine-treated copper metal-organic frameworks which show highly selective activity for ascorbate oxidation and can serve as an efficient ascorbate oxidase-mimicking material in sensitive sweat sensors.

Cytology is commonly used for cervical cancer screening or triage. Here, the authors used deep learning to develop a liquid-based cytology screening approach to detect cervical cancer in both community and hospital-based settings.

ELD1, a CCHC-type zinc finger protein, is found to modulate alternative splicing of the core oscillator gene OsCCA1 and thereby regulate photoperiodic flowering in rice. This reveals additional links between light signaling and the circadian clock.

The brainstem’s internal architecture and response to TBI are underestimated. Here, authors show distinct neuronal subtypes in the brainstem and reveal that disconnection of oligodendrocytes near the IV ventricle and altered locus coeruleus connectivity occur after TBI.

Effectiveness of the hepatitis E vaccine HEV 239 amongst high-risk groups isn’t well studied. Here, Zhuang et al. analyse a decade of surveillance data (2007–2017) from Dongtai, China, and estimate HEV 239 effectiveness of 72% amongst hepatitis B virus infected people.

The quality of perovskite films and lateral contact of subcells limit the performance of perovskite solar modules. Here, authors regulate the growth of perovskites on low temperature substrate and apply an additional scribing step, realizing certified efficiency of 22.73% and long device stability.

Analyses of whole-genome sequencing data in children and validation in mouse models show that offspring born from blastocyst-stage embryo transfer have shorter leukocyte telomere lengths.

MRGPRX1 is a key GPCR expressed in the DRG for itch perception, generating scratch or avoidance behaviors. Here, authors provide structural and pharmacological insights into itch sensation, activation and G-protein signaling downstream of MRGPRX1.

The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

Diffuse intrinsic pontine glioma (DIPG) is driven by H3K27M oncohistones, but the exact related mechanisms are poorly understood. Here, the authors identify an H3.3K27M oncohistone-driven CREB5/ID1 axis that promotes transcriptional changes and progression in DIPG, which could represent a potential therapeutic target.

In a large-scale, international, multicenter, phase 1/1b trial, treatment of patients with advanced solid tumors with the B7H3-targeting antibody–drug conjugate YL201 was safe and showed preliminary clinical efficacy.

Robotic applications in complex environments require high-frequency and versatile oscillators. Here, the authors present a pneumatic oscillator that integrates hybrid soft, elastic, and rigid structures. It achieves a maximum frequency of 51 Hz, enabling fast, pre-programmable, and tunable motion patterns.

The cellular origins of a precancerous condition called Barrett’s oesophagus have been unclear. Tracking and analysis of epithelial cells at the affected site could shed light on the problem. See Letter p.529

The authors show that SARS-CoV-2-specific T cells in the lung are key to fighting infection and persist after viral clearance, contributing to long-term immunity and protection.

The synthesis of ¹⁸F-labeled positron emission tomography (PET) tracers is difficult and typically requires anhydrous conditions. Here, the authors developed organophosphine precursors that allow for quick, high-yield synthesis of ¹⁸F-labeled probes in either organic solvents or aqueous media.

Traditional electrorefining process is limited by deposition potential of the metal itself. Here, the authors explore an in-situ anodic precipitation process based on different solubility of target metal chlorides that can efficiently separate components of aluminum alloys.

Conventional silicon-based transistors, which sit at the heart of every computer, are fast approaching the limit of miniaturisation. Here, Meng et al demonstrate a field-effect transistor composed of a single rutheniumdiarylethene molecule with large on/off ratio.

Aryl hydrocarbon receptor (AHR) is an emerging immune-related drug target. Here, the authors report the crystal structures of AHR with six agonists bound, revealing the molecular mechanisms of diverse ligand binding and allosteric activation of AHR.

High-quality genome sequence of cultivated peanut comprising 2.54 Gb with 20 pseudomolecules and 83,709 protein-coding gene models provides insights into genome evolution and the genetic mechanisms underlying seed size and leaf resistance in peanut.

Cryptochiral compounds are indispensable in biology systems and medical applications, yet the development of high-performance detection method remains challenging. Here, the authors report hinge-like dinuclear Pt(II) complexes as stereodynamic probes for cryptochirality sensing.

Single-atom catalysts hold great potential for the electrochemical oxygen reduction reaction in hydrogen peroxide production. Here, the authors report Fe single-atom catalysts derived from microbial protein precursors, which enhance both the selectivity and activity for hydrogen peroxide production.

The cellular origins of a precancerous condition called Barrett's oesophagus have been unclear. Tracking and analysis of epithelial cells at the affected site could shed light on the problem. See Letter p.529

The bacterial adhesin, RadD, enhances the ability of Fusobacterium nucleatum to interact with colorectal cancer cells and promote tumour development in mice.

Minimally invasive irreversible electroporation shows some therapeutic promise in irresectable pancreatic cancers that are notorious for poor survival. Here authors combine this with administration of a hydrogel microsphere vaccine that augments the antigen presentation T cell response cascade that naturally initiates following ablation.

Liquid state coacervates are an area of interest, but many applications remain to be explored. Here, the authors report the development of coacervate-pore complexes for the control of through-pore transport.

Bimetallic zinc and gold porphyrin self-assembled into 2D nanosheets as nanoscale optoelectrodes. This design achieves exceptional photoelectric performance under visible one-photon and near-infrared two-photon excitation, enabling far-field optical modulation of single neurons.

Immersive virtual reality requires artificial sensory perceptions to simulate what we feel and how we interact in the natural environment. Zhang and colleagues present a first-person, human-triggered, active haptic device that allows users to experience mechanical touching with various stiffness perceptions from positive to negative ranges, achieved by the unique benefits of curved origami.

Nucleocytoplasmic large DNA viruses, or ‘giant viruses’, infect a wide range of eukaryotes and can exchange genetic material not only with their hosts but also with bacteria and phages. Here, the authors show that many giant viruses carry diverse antibiotic resistance genes, which are associated with mobile genetic elements and genes encoding potential virulence factors.

Inspired by the art of kirigami, a haptic device based on a miniaturized electromechanical structure combined with skin as an elastic, energy-storing element demonstrates bioelastic state recovery and can be used in sensory substitution.

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.