Core-shell & co-doping nanoscale metal-organic particles (NMOPs), with high strong NIR absorbance, high radio-sensitizing capability and intrinsic biodegradability are developed via a post-synthesis cation exchange strategy for multimodal imaging guided synergistic thermo-radiotherapy. After coating with polydopamine and further conjugation with polyethylene glycol (PEG), such NMOP-PEG nanoparticles show effective tumor retention, and could be utilized for effective synergistic thermo-radiotherapy of cancer. Importantly, those NMOPs show no appreciable toxicity to the treated mice, and could be rapidly excreted from the body owing to their biodegradability.
